[PDF] Top 20 The cardiotoxicity of mitoxantrone: a mechanistic approach using in vitro and in vivo models.
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The cardiotoxicity of mitoxantrone: a mechanistic approach using in vitro and in vivo models.
... 100nM and 1µM MTX caused an increase and no alteration in the mitochondrial membrane potential, ...used the same cell model and similar MTX concentrations, it is possible that a ... See full document
190
Study of the effect of titanium oxide glass powder in vitro and in vivo
... from the rivers of Northern India, and is currently used as model ...community of more than 500 laboratories and 4,000 researchers registered on the Zebrafish Information Network ... See full document
70
Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach
... at the same temperature of 23 ± 1 °C or (b) exposed to a temperature challenge of 13 ± 1 °C for 15 ...days. The circuit consisted of 200 L fibreglass tanks in a semi-closed sea ... See full document
14
In vitro and in vivo establishment and characterization of resistant and metastatic human osteosarcoma models
... 20°C in low ozone concentration ...images using the Feature Extraction software ...under the R statistical environment in ...log2(Test/Ref) and normalized according to their ... See full document
194
In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections.
... In the present investigation, albendazole, levamisole, and pyrantel pamoate have been extensively studied in vitro and in ...vivo. The results obtained are ... See full document
7
GC - MS metabolomic studies in Prostate Cancer: a novel approach using in vitro models
... is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western ...on the measurement of serum prostate specific antigen (PSA) ... See full document
142
Evaluation of neuroprotective and neurotoxic functions of different microglia phenotypes in Alzheimer’s disease onset and progression, using in vitro and in vivo models
... Therefore, the effects of peripheral immunostimulation by intravenously administered LPS dose are indirect and some of them mediated by the cells that comprise the ...before ... See full document
250
Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery
... studies in dogs also have the potential to define heritable and environmental risks, methods to detect UBC earlier, and methods to more effectively treat UBC, important information to better ... See full document
34
In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.
... forward in therapeutic drug develop- ment.[6, 9] Patterns of pharmacological activity responsible for antipsychotic efficacy remain the subject of ongoing ...polypharmacology approach ... See full document
27
Characterization of the toxic potential of nanomaterials using in vitro cell models
... hours, and determined that there was production of DNA damage and formation of ROS, not dependent of CNT concentration ...Ghosh and collaborators performed a comet assay on human ... See full document
94
Using Group II Introns for Attenuating the In Vitro and In Vivo Expression of a Homing Endonuclease.
... expand the concept of the “intron based on switch” as a potential regulatory ele- ment for HEase expression, a non-native group IIB intron (rI1) from Scenedesmus obliquus (GenBank accession number ... See full document
24
Unreveling pathways of cyto and genotoxicity of AgNP in lung cells: in vitro and in vivo approach
... role in the MPS, but the latter was not incorporated into the PBPK-model which could be an explanation of the lower modeled silver levels in ...release and storage ... See full document
209
The Synthesis and in Vitro Toxicological Evaluation of the Mitoxantrone Naphthoquinoxaline Metabolite: A Comparative Study with the Parent Drug
... Behnia and Boroujerdi used phenobarbital as an inhibitor of aldo/ketoses reductases after which they used DOX at 10 mg/kg, ...decrease of doxorubicinol levels in vivo, as well as a ... See full document
153
In vitro and in vivo experimental models for drug screening and development for Chagas disease
... 75%) and treated with the dose established in the In vivo I ...to the onset of ...25 and 30 dpi and the viability of animals will be ... See full document
6
In vitro and in vivo experimental models for drug screening and development for Chagas disease
... 75%) and treated with the dose established in the In vivo I ...to the onset of ...25 and 30 dpi and the viability of animals will be ... See full document
6
Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach
... activity of AMD has also been demonstrated through both in vitro and in vivo models, showing a mode of action related to mitochon- drial damage and ... See full document
6
Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro
... display and SELEX are powerful methodologies to be employed in a variety of systems to approach different questions, from the understanding of cell biology to ...as the ... See full document
16
Genotoxicity of Microcystin-LR in In Vitro and In Vivo Experimental Models
... 𝜇M of MCLR) previously fixed and spread onto glass slides for micronucleus analysis were also used for the FISH assay, performed according to manufacturer ...𝜇g/mL) and untreated cultures were ... See full document
10
Tumor microenvironment models: ex vivo, in vitro and in silico approaches to address targeted therapies
... In the last culture day (14 days after microencapsulation), capsules from mono- and co-cultures were collected and fixed as previously ...compare the nanoscale elastic properties ... See full document
270
In vitro - in silico approach for the prediction of in vivo performance of drugs
... enables the study of systems through its graphical representation. The program uses Compartments, Flows, Converters, and Connectors as building ...net of whatever flows out of ... See full document
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