[PDF] Top 20 Cardiovascular impact of cytotoxicity and aging in protein aggregation
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Cardiovascular impact of cytotoxicity and aging in protein aggregation
... , Xie CM, Xie Z, Xie Z, Xilouri M, Xiong Y, Xu C, Xu C, Xu F, Xu H, Xu H, Xu J, Xu J, Xu J, Xu L, Xu X, Xu Y, Xu Y, Xu ZX, Xu Z, Xue Y, Yamada T, Yamamoto A, Yamanaka K, Yamashina S, Yamashiro S, Yan B, Yan B, Yan X, Yan ... See full document
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Methylglyoxal effects on protein aggregation and amyloid formation
... properties and thereby have a significant impact on protein function, are often found in unstructured regions (Gsponer & Madan Babu, ...participate in regulatory and ... See full document
195
Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity
... impairment of ppIAPP processing and the consequent accumulation of intermediate immature forms may contribute to the formation of toxic intracellular oligomers (Paulsson and Westermark, ... See full document
13
Identification of human tRNA modifying enzymes involved in protein aggregation
... Knockdown of most of the ones belonging to the Elongator Complex resulted in accumulation of misfolded proteins in the cell cytoplasm (Figure ...deregulated in distinct ... See full document
94
SIRT2: in the crossroad of aging, neurodegeneration and autophagy
... inhibition of SIRT2 can ameliorate αSyn- mediated toxicity, suggesting a possible regulation of aSyn aggregation by SIRT2 (Outeiro et ...aSyn aggregation, we knocked-down endogenous SIRT2 ... See full document
33
Physical effects upon whey protein aggregation for nano-coating production
... one of the two intramolecular disulfide bonds of a non-denatured monomer to form a dimer; an intermolecular disulfide bond is then formed and a new reactive free SH group is now available on the ... See full document
32
Heparin induces harmless fibril formation in amyloidogenic W7FW14F apomyoglobin and amyloid aggregation in wild-type protein in vitro.
... deposits in most amyloid diseases, and there is evidence to support their active role in amyloid fibril ...purpose of this study was to obtain structural insight into GAG- protein ... See full document
13
Predictors of aging and potential of FTIR to detect protein aggregates
... samples of human tissue and body fluids and has shown potential to support clinical pathology, ...detecting and grading of disease [162,163]. In this context FTIR spectroscopy ... See full document
96
Disulfide scrambling in superoxide dismutase 1 reduces its cytotoxic effect in cultured cells and promotes protein aggregation.
... C6A protein, the migration rate of C111A, wild-type and wild-type (IAM) in both dimeric and monomeric forms were clearly slower compared to C6/111A with its native disulfide intact but ... See full document
11
Does proteostasis get lost in translation? Implications for protein aggregation across the lifespan
... alterations in mTOR pathway prolong lifespan The target of rapamycin (mTOR) pathway plays an important role in lifespan extension ( Steffen and Dillin, 2016 ) and is strongly affected ... See full document
10
Effect of memantine in aging : the impact of hippocampal dependent memory
... molecular and physiological alterations observed in aging are associated to impairments in learning and memory processes that are recognized as one of the major features ... See full document
67
Dissecting the role of Proteolysis and Cytoskeleton remodeling in protein aggregation related diseases
... cleavage of Aβ in physiological conditions by using N2A-APPswe cells, a CNS cell line that stably expresses APP Swedish mutation producing high levels of Aβ ...cleavage of Aβ, this cell based ... See full document
100
Protein aggregation and proteostasis in aging mice
... In aging, cellular mechanisms involved in maintaining protein integrity such as the UPR and UPS become inefficient in degrading misfolded proteins ...accumulate in cells ... See full document
70
Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention.
... crossroads of several intracellular signaling pathways and plays important functions in regulating cellular survival, proliferation, transcription, and metabolism ...F344BN aging rat ... See full document
9
Structural effects of protein aging: terminal marking by deamidation in human triosephosphate isomerase.
... not in- duce gross conformational changes in HsTIM (S2 Fig); however, the kinetic and stability assays (Figs 2, 3, 4, 5 and 6) indicate that this mutation has disparate effects on the ... See full document
23
Genotoxicity and cytotoxicity of Cr(VI) and Pb²+ in Pisum sativum
... distress in the biochemical aspects of ...(2007) and Vernay et al. (2008) discussed that despite the loss of biomass and wilting were common symptoms of Cr exposure little was ... See full document
178
Chemical Kinetic Strategies for High-Throughput Screening of Protein Aggregation Modulators
... pharmacophore of the soluble pro- tein (Figure 3c) or, alternatively, the metastable oligomers (Fig- ures ...solubility of the target protein, shifting the on- and off- pathway equilibria ... See full document
9
The neuronal S100B protein is a calcium-tuned suppressor of amyloid- aggregation
... presence and absence of S100B, were used to seed A42 ag- gregation ...processes and increase aggregation rate of monomeric A42 ...A42 aggregation is measured in the ... See full document
14
Biochemistry and cytotoxicity of a-aminoketones.
... mover in vitro em ferritina e apoferritina: (i) modificação no seu comportamento eletroforético; (ii) oxidação de resíduos de trip- tofano e cisteína; (iii) perda da atividade ferroxidásica e (iv) perda da ... See full document
9
Cytotoxicity and genotoxicity of carbon nanotubes.
... CYTOTOXICITY AND GENOTOXICITY OF CARBON ...cyto- and genotoxicity of carbon nanotubes (CNTs). In this work, we discuss that many of the incongruous arguments are probably ... See full document
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