Top PDF The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
... that the E3 ubiquitin ligase activity of Trip12 is indispensable for mouse ...that Trip12 promotes the ubiquitination and degradation of ...
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Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.
... abnormalities, the patients usually survive to adulthood. Thus, the Cul4b mutant mice are more severely ...affected. The mechanism underlying this species- specific difference in phenotypic severity ...
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HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.
... activation is likely regulated at multiple levels, including tran- scriptional, translational and post-translational mechanisms that control Glis3 protein activity and/or its expression ...that the ...
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Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.
... from the epiblast of early blastocysts, can self- renew and maintain a pluripotent, undifferentiated state in vitro by extrinsic factors, such as LIF and Bmp, and intrinsic factors, including stem cell ...
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Characterization of the Arabidopsis thaliana E3 ubiquitin-ligase AtSINAL7 and identification of the ubiquitination sites.
... by the proteasome is an important mechanism in regulating key cellular ...ubiquitination is carried out by a three step process involving ubiquitin (Ub) activation by a E1 enzyme, the ...
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Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.
... by the NetPhos score, figure 3a) and were subsequently mutated to phenylalanine in order to assess their role in regulating TRIM21 ...residue is also predicted to be phosphorylated in murine TRIM21 (data ...
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The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation.
... including the NleL (ECs1560) locus ...HECT-like E3 ubiquitin ligase [28,30,45]. The substrate and biological function of NleL remains ...ubiquitination is often used in ...
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cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
... Inhibitor of apoptosis proteins (IAPs) are phylogenetically conserved proteins characterized by the presence of at least one Baculovirus IAP Repeat (BIR) motif, a zinc-binding structure of ...
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REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I.
... It is well established that RIG-I is an essential cytosolic sensor for the innate immune response to certain ...However, the regulatory mechanism of RIG-I-mediated signaling has ...
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The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1.
... from the known roles of Hoxa2. Indeed, p53 is known to be mainly involved in cell cycle arrest, senescence and apoptosis ...which is not in line with Hoxa2 functional studies that led to ...
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The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans
... regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of ...
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A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila.
... Cullin-3 is highly expressed during late murine spermatogenesis ...in the cytoplasm of developmentally advanced murine sperma- tids, and mice carrying a null klhl10 allele are infertile due to ...
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The Ubiquitin Ligase CBLC Maintains the Network Organization of the Golgi Apparatus.
... Despite the organizational complexity of this organelle, it is increasingly appreciated that the Golgi is quite plastic and ...which the whole organelle orients towards ...
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Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants.
... Moreover, the mutant used here, rsp5-1, was described earlier as showing no defect in the ubiquitination of carboxypep- tidase S precursor (pCPS) ...Also the defect in Sna3-GFP fusion protein ...
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Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping.
... reduces the level of the other. The Roc2-Cul5 complex is conserved in other species including ...What is the function of the Roc2-Cul5 complex in vivo? A ...
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Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1α and β in lamin A/C knock-down cells.
... investigate the effects of reduced expression of lamin A/C on HP1 stability, we employed a vector-based shRNA system to knock down endogenous lamin A/C levels as described in Materials and ...loss ...
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The Economics of Sub-optimal Policies for Traffic Congestion
... paper is the work of Gallego, Montero, and Salas ...find the policies that impose driving restrictions may lead to a higher number of cars on the ...on the same direction. ...
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The E3 ligase AtRDUF1 positively regulates salt stress responses in Arabidopsis thaliana.
... investigate the tissue-specific expression pattern of AtR- DUF1, a fusion gene comprising the native AtRDUF1 promoter, a ...upstream of the start codon of AtRDUF1 CDS, and ...
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Field Cancerisation of the Upper Aerodigestive Tract: Screening for Second Primary Cancers of the Oesophagus in Cancer Survivors
... cancers of the oesophagus, lungs, and head and neck region ...90% of the tumours in head and neck are squamous cell carcinomas, and at least 75% of them are attributable to the ...
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γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
... At the amino acid sequence level, human c-tubulin 1 and c-tubulin 2, respectively, show ...with the corresponding mouse isoforms (Table S1) [23]. To study the subcellular localization and ...
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