[PDF] Top 20 Impact of truncated O-glycans in cancer associated CD44 variants

... treated in the Braga Hospital, between 2005 and 2010 with CRC diagnosis and submitted to surgical treatment was collected ...level of positive lymph nodes was not described in all ...type of ... See full document

... identification of CD44 as carrier of truncated O-glycans we assessed the capacity of our models to bind to ...HA. CD44 is known to be the major binding protein of ... See full document

... state; in the partially disordered form of hyaluronan binding domain (HABD), basic amino acids in the C-terminal region can gain sufficient mobility to form direct contacts with bound HA to further ... See full document

... effects of the microRNA (miRNA) processing genes Gemin3 and Gemin4 on cellular signaling pathways could have a major impact on the risk of ...with cancer susceptibility have been ...precision ... See full document

... breast cancer (BC) cases account for 5-10 % of all BC cases and are mainly associated with inherited mutations in BRCA1 and BRCA2 ...one of the main pathways that repair DNA ... See full document

... absence of nomenclature standardization also emerges as a key issue, making inter-study comparisons and clinical translation almost ...observations in hematopoietic and epi- thelial cells; gp116 and gp85 ... See full document

... association of HFE (High Iron FE) major var- iants with breast cancer risk and behavior has been a matter of discussion for a long ...their impact on the ex- pression of iron-related ... See full document

... and truncated O-glycans, Tn (GalNAcα1-O-Ser/Thr), STn (NeuAcα2–6GalNAcα1-O-Ser/Thr) and T (Galβ1–3GalNAcα1- O-Ser/Thr [ 10 ...expression of Tn and STn as being highly specific for these malignant ... See full document

... uptake in several tissues, acting also on lipid synthesis in the liver [ 1 ...produced in the liver and in tissues where they act in both the autocrine and paracrine ...mediators ... See full document

... uptake in several tissues, acting also on lipid synthesis in the liver [ 1 ...produced in the liver and in tissues where they act in both the autocrine and paracrine ...mediators ... See full document

... (p.R258Q) in the primary colon cancer cell line SW480 and not in lymph node metastatic cell line ...feature of SW480 and SW620 cell lines is that they are derived from primary and secondary ... See full document

... ratio of 1:50 (w/w) and left overnight at room ...addition of 2% formic acid and then the samples were centrifuged at 14,000 × g for 10 min to precipitate any lipids present in the ...using ... See full document

... measured in light indoor clothes and without ...measured in standing position midway between the iliac crest and the lower costal ...evaluation of quantitative traits all analysis are performed ... See full document

... deposition of calcium crystals - hydroxyapatite or CPPD- can also occur in the spinal ligaments [257, 258], but it is usually difficult to distinguish from ossification ...[255]. In addition to the ... See full document

... involved in cell motility as well as expression of epithelial and differentiation markers (Figure ...upregulation of Rho A and Rho C, proteins known to stimulate cell motility [16], in Rb ... See full document

... complexity of configuring an iRAP experiment, a user friendly web interface was designed to allow the creation of said experiments and the retrieval of ...reads in FASTA or FASTQ ... See full document

... frequencies of the SNPs rs2273773 T>C and rs7895833 A>G in SIRT1 gene were not in accordance to those expected under Hardy- Weinberg ...group in this same sample, were following ... See full document

... 90% of cancer deaths and a major problem in cancer ...management. In particularly, the incidence of brain metastases, which are often a sign of poor prognosis, diminished ... See full document

... expression of a large number of genes related to tumor progression, including those for cyclin D1, c-myc, vascular endothelial growth factor, and survivin is controlled via the Wnt/b-catenin pathway ... See full document

... maintained in a room at 20–22uC on 12 h light/dark cycle with food and water available ad ...injections of MPTP (20 mg/kg, free base; Sigma-Aldrich) dissolved in PBS at 2 h intervals, and were ... See full document