[PDF] Top 20 Insights into the physiological function of cellular prion protein
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Insights into the physiological function of cellular prion protein
... class of infectious agents in which a protein, PrPsc (prion scrapie), appears to be the sole component of the infectious ...animals. The mechanism of disease ... See full document
11
The cellular prion protein negatively regulates phagocytosis and cytokine expression in murine bone marrow-derived macrophages.
... Phagocytosis of pathogens initiates the innate immune response ...degradation of microbes to help clear the invading pathogens [3]. The initial stage of the elimination ... See full document
9
A receptor for infectious and cellular prion protein
... against the prion comple- mentary peptide recognized a 66-kDa mem- brane protein which binds recombinant and cellular PrPc in vitro and in ...blocking the receptor with serum against ... See full document
7
Insights into cytochrome bc
... modeling of CYB and ISP subunits of Pfbc 1 (3D7) - Homology modeling was carried out using the Modeller software version 9v2 using standard pa- rameters (Sali & Blundell ...for the CYB and ... See full document
10
Insights into Protein-Ionic Liquid Interactions Aiming at Macromolecule Delivery Systems
... in the field of structural and functional stabilization of protein entities, such as enzymes, recombinant proteins, bioactive peptides, bacteriophage particles, or protein-based ... See full document
16
The spindle assembly checkpoint: new insights into its function, regulation and therapeutic implications
... glance, the question may seem difficult to answer. Indeed, given the role of Bub3, and most probably also of dynein, in promoting end-on attachments, one should expect a rather worst ... See full document
209
NCAM1 Polysialylation
... surrounds the physiological function of the cellular prion protein (PrP C ...knowledge of its function will shed light on its contribution to ... See full document
25
Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain.
... member of the importin-b/karyopherin-b family of nuclear transport factors, is responsible for exporting many proteins and ribonucleoproteins from the nucleus to the cytosol ...and ... See full document
10
Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.
... evidence of direct interactions between the proteins central to AD and prion ...that the cellular prion protein can act as a receptor for Ab, with Ab oligomers binding to ... See full document
8
Insights into the cellular function of YhdE, a nucleotide pyrophosphatase from Escherichia coli.
... determine the effect of YhdE on cell growth, we systematically investigated growth profiles of ...and the yhdE-knockout (KO) strain under varying physiological conditions ...media, ... See full document
15
Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein.
... features of an unfolded protein in NMR experiments, and under physiological conditions had a higher affinity for dodecyl- phosphocholine micelles, being incorporated into the micelle in ... See full document
11
Crystallization and preliminary X-ray diffraction analysis of crotoxin B from Crotalus durissus collilineatus venom
... example of molecular potentia- tion, since the CA subunit hinders the formation of nonspecific interactions between the CB subunit and its substrates or other ...Indeed, the CA ... See full document
3
The role of the transcription factor SIM2 in prostate cancer.
... evaluate the SIM2s and SIM2L gene expression in the human prostate total RNA samples and normalized by 2 control genes ALSA1 and HPRT (QuantiGene ...value of SIM2s or SIM2L in a given sample was ... See full document
10
The prion protein and New World primate phylogeny
... depict the same phylogenetic ...However, the monophyletic status of the New World monkeys is strongly supported by significant bootstrap val- ues (BS = 95%) and decay indexes (DI = ...in ... See full document
6
Insights into the role of hydration in protein structure and stability obtained through hydrostatic pressure studies
... clearly the case for apo-myoglo- bin (9-15), for which moderate pressure re- sults in the population of a species with structural characteristics quite similar to those of the ... See full document
7
Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.
... familial prion disease located in the C-terminal region of PrP (121–231) do not reduce the stability of PrP ...However, the proline to leucine mutation at residue 101 of ... See full document
9
Interleukin-6 contributes to myocardial damage in pregnant rats with reduced uterine perfusion pressure
... sion of the spiral arteries. The development of a model that exploits this reduction in uterine perfusion pressure and flow is a natural alternative for study ...kinds of experi- mental ... See full document
7
The Impact of the Expansion of the Bolsa Familia Program on the Time Allocation of Youths And Their Parents Lia Chitolina Miguel Nathan Foguel Naercio Menezes-Filho
... household, the program caused an increase of more than 11 percentage points in the probability of attending ...in the estimated impact is the fact that his/her family is only ... See full document
39
Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins
... composed of multiple domains known to bind distinct proteins (see supplementary material ...S2a). The first 44 amino acids comprise a somatomedin-like domain, which harbors plasminogen activator ...by ... See full document
12
Insights from amphioxus into the evolution of vertebrate cartilage.
... downstream of CNC specfiers and upstream of effector genes like Col2a1 and Aggrecan, Barx1 physically interacts with Sox9 to directly activate Collagen2a1 expression ...SoxE function[16]. In ... See full document
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