[PDF] Top 20 Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium
Has 10000 "Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium" found on our website. Below are the top 20 most common "Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium".
Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium
... number of compounds have been shown as potential inhibitors of the ...tuberculosis efflux systems (Viveiros et ...thioridazine and chlorpromazine and the phenylalkylamine verapamil ... See full document
18
Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.
... outbreak of extensively drug-resistant tuberculosis (XDR-TB) has become an increas- ing problem in many TB-burdened ...underlying drug resistance mechanisms, including the genetic ... See full document
20
Evaluation of rapid alternative methods for drug susceptibility testing in clinical isolates of Mycobacterium tuberculosis
... included in LJ medium at a concentration of: ...EMB, and 4 µg/ml for SM; 1000 mg/l of potassium nitrate (KNO 3 ) was also ...Part of the inoculum, adjusted to equal the density ... See full document
8
The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks.
... particular isolates possessed rpoB mutations that were associated with low-level RIF-resistance as confirmed by their MICs ...[10,18]. In another study, isolates from an outbreak of ... See full document
4
Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species
... class of medications most commonly used to fight infections caused by Candida ...to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the ... See full document
8
Genotypic and phenotypic detection of efflux pump in Rhodococcus equi
... The efflux mechanism by extruding of EtBr was de- tected in 20% (18/90) of ...equi isolates tested, including: 61.1% (11/18) clinical, ...soil and 16.7% (3/18) feces ... See full document
5
COMPARATIVE EVALUATION OF THE NITRATE REDUCTASE ASSAY AND THE RESAZURIN MICROTITRE ASSAY FOR DRUG SUSCEPTIBILITY TESTING OF MYCOBACTERIUM TUBERCULOSIS AGAINST FIRST LINE ANTI-TUBERCULOSIS DRUGS
... NRA-7H9 and REMA were used to determine the susceptibility of 57 clinical ...Three isolates were resistant to INH by REMA and susceptible by ...was resistant to INH ... See full document
5
Plasmidbased controls to detect rpoB mutations in Mycobacterium tuberculosis by quantitative polymerase chain reactionhighresolution melting
... Mutations in the RRDR region are usually found in clinical isolates resistant to rifampicin and most of these mutations occur in codons 516, 526 ... See full document
4
Imipramine is an orally active drug against both antimony sensitive and resistant Leishmania donovani clinical isolates in experimental infection.
... problem in the Indian subcontinent and MWs upregulate both MRP-1 and P-gp upon infection with SSG-R LD leading to efflux of antimonials ...monocytes of kala-azar patients harbor- ... See full document
15
Molecular profiling of drug resistant isolates of Mycobacterium tuberculosis in the state of Santa Catarina, southern Brazil
... threat and one of the main contributing factors to tuberculosis (TB) ...goal of this study was to analyse the molecular profile of multidrug-resistant TB (MDR-TB) in the state ... See full document
6
Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil
... tuberculosis clinical isolates studied, ndh gene mutations were detected in two ...(8.7%) and no mutation was detected in the 13 INH- susceptible isolates ...mutation ... See full document
3
Detection of genomic mutations in katG, inhA and rpoB genes of Mycobacterium tuberculosis isolates using polymerase chain reaction and multiplex allele-specific polymerase chain reaction
... detection of INH and RIF in 174 clinical isolates of MTB in Turkey, distinct PCR banding patterns were observed for different mutation profiles and the correlation ... See full document
6
Mutations in rpoB and katG genes in Mycobacterium isolates from the Southeast of Mexico
... frequent mutations associated with rifampin and isoniazid resistance in Mycobacterium are the sub- stitutions at codons 531 and 315 in the rpoB and katG genes, ...aim ... See full document
5
Sequence analysis of coding DNA fragments of pfcrt and pfmdr-1 genes in Plasmodium falciparum isolates from Odisha, India
... emergence and spread of malaria parasites resistant to antimalarial drugs is the major problem in malaria ...basis of the parasite’s resistance to the antimalarial drug ... See full document
7
SRR Simonetti+ , HG Schatzmayr, JP Simonetti
... for drug resistance testing in HIV-1 infection are available detecting mutations that confer phenotypic resistance, either by genotyping all relevant codons or by hybridization-based detection ... See full document
7
Increased thiol levels in antimony-resistant Leishmania infantum isolated from treatment-refractory visceral leishmaniasis in Brazil
... evidence of an association between drug and microbicidal resistance mechanisms, and their associa- tion with increased parasite virulence is concerning be- cause of the high ... See full document
7
Epidemiology and Clinical Characteristics of Pediatric Drug-Resistant Tuberculosis in Chongqing, China.
... tuberculosis isolates may have an enhanced ability to disseminate from the initial infection site and to cause disease in both the initial infection site within the thorax and the ... See full document
12
Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil
... permeability of the cell wall due to the lipid-rich composition and the presence of mycolic acids that considerably decreases the intracellular access of antibiotics (Brennan and ... See full document
12
First evaluation of drug-resistant Mycobacterium tuberculosis clinical isolates from Congo revealed misdetection of fluoroquinolone resistance by line probe assay due to a double substitution T80A-A90G in GyrA.
... (ofloxacin and moxifloxacin) and injectable second-line drug (amikacin), and by genotypic MTBDRsl ...amikacin and fluoroquinolones thus excluding the presence of XDR strains ... See full document
6
Clinical data and molecular analysis of Mycobacterium tuberculosis isolates from drug-resistant tuberculosis patients in Goiás, Brazil
... one of the major concerns regarding tuberculosis (TB) infection worldwide because it ham- pers control of the ...for drug resistance development is of the highest ...investigate ... See full document
7
temas relacionados