[PDF] Top 20 Phenotypic and Target-based Strategies for Drug Discovery in Trypanosomes
Has 10000 "Phenotypic and Target-based Strategies for Drug Discovery in Trypanosomes" found on our website. Below are the top 20 most common "Phenotypic and Target-based Strategies for Drug Discovery in Trypanosomes".
Phenotypic and Target-based Strategies for Drug Discovery in Trypanosomes
... diseases in the world, affecting especially poor people in the African and American ...disease in particular is caused by the protozoan parasite Trypanosoma cruzi and is responsible for ... See full document
262
Computational drug discovery for the Zika virus
... Structure-based drug design (SBDD) is a very useful approach when the biological target is known, and its 3D structure is ...available. Based on the target 3D structural ... See full document
10
Discovery of target directed drugs for neurodegenerative diseases based on benzopyrone scaffold
... acquired in this study to demonstrate that 3-aryl- coumarin is a valid scaffold for the design of novel A 3 -selective or A 1 A 3 dual AR ...ligands. In particular, compounds 1, 6–9, and 12 were the ... See full document
307
Natural products as leads in schistosome drug discovery
... the discovery of NPs with schistosomicidal activity is virtual screening (VS), which is defined as the use of computational filters in a database of chemical structures to predict the bioactivity of a ... See full document
32
Metabolomics and Its Potential in Drug Discovery and Development From TCM
... years in Asia and attracted worldwide interest [2] . In the past, “one disease- one target-one drug” and “one drug fits all” modes have been used in the treatment ... See full document
7
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information
... new drug target should be a molecule that is essential to the parasite, for which high affinity in- hibitors can be identified and which have little or no ef- fect on the eventual human ... See full document
11
Neural cell models for disease modeling and drug discovery
... β-amyloid and phosphorylated tau protein (Israel et ...lineages and were up to two times more sensitive to oxidative stress-induced apoptosis than healthy neural cultures (Briggs et ...levels and ... See full document
204
Structure based drug design for the discovery of promising inhibitors of human Bcl-2 and Streptococcus
... the target has been identified, its implications on the disease phenotype must be validated through in vitro ...a target is using antisense technology, in which RNA-like oligonucleotides are ... See full document
149
Current screening methodologies in drug discovery for selected human diseases
... the phenotypic approach, the first steps of the research for anticancer leads rely on the in vitro assessment of anticancer ...control. In many types of cancer, such as pancreatic cancer, the ... See full document
31
Prediction of drug-target interactions for drug repositioning only based on genomic expression similarity.
... Small drug molecules usually bind to multiple protein targets or even unintended ...Such drug promiscuity has often led to unwanted or unexplained drug reactions, resulting in side effects or ... See full document
9
miRNA-29 bioseparation and target delivery strategies for Alzheimer's disease
... studies in the last decade, dysregulation of expression levels of miRNAs, as well as their dysfunction in the brain have been associated with the pathogenesis of various diseases of the nervous system, ... See full document
300
Contribution to drug discovery and development for tauopathies using yeast as a model
... for drug discovery and development, particularly products derived from bacteria, following the failure of automated chemical synthesis in delivering new drugs in the market (Lawrence, ... See full document
259
Non-clinical studies required for new drug development – Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies
... physiologists and chemists, which was the basis for the emergence of the large global pharma- ceutical ...physicians and biostatisticians also ...observed in the field of new drug development, ... See full document
9
The next opportunity in anti-malaria drug discovery: the liver stage.
... grown in red blood cell ...[22], and most recently GlaxoSmithKline re- ported the results of a high-throughput screen measuring the parasite’s lactate dehydrogenase (LDR) activity ...[23]. In ... See full document
5
"Leishmania spp. Infection Model Optimization for Drug Discovery Purposes"
... used in drug discovery because they reflect more accurately the complexity of the entire living ...screens, and have higher hit rates than biochemical ...development and evaluate their ... See full document
120
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.
... plate-to-plate and the day-to-day variabilities of HCA measurements are usually characterized by the Z’ factor or the strictly standardized mean difference (SSMD) ...effort in HCA to address ... See full document
16
Drug discovery and computational strategies in the multitarget drugs era
... targets in cancer development and explored potential strategies to inhibit these ...structure and biological data of 1300 consisting of TCT, 3 cytoplasmic TKs (ABL, LCK, and SRC), ... See full document
25
Prediction of drug-target interactions and drug repositioning via network-based inference.
... of drug discovery and design. It is time consuming and costly to determine DTI ...DTI. Based on complex network theory, three supervised inference methods were developed here to predict ... See full document
12
Strategies towards expansion of chemical space of natural product‑based compounds to enable drug discovery
... available in house libraries, commercial sources, or NP databases, using a “pseudo-retrosynthetic” approach (RECAP) (Rodrigues et ...by in silico degradation. In this case, in silico reactions ... See full document
16
CURRENT TRENDS IN DRUG DISCOVERY: TARGET IDENTIFICATION TO CLINICAL DEVELOPMENT OF THE DRUG
... the drug discovery process has been revolutionized with the involvement of some newer ...techniques. Target based drug design is more advantageous, time consuming and ... See full document
5
temas relacionados