[PDF] Top 20 Predicting the antigenic structure of the pandemic (H1N1) 2009 influenza virus hemagglutinin.

... The pandemic influenza virus (2009 H1N1) was recently introduced into the human ...population. The hemagglutinin (HA) gene of 2009 H1N1 is derived ... See full document

... structures of the HA protein of the 2009 pdm A(H1N1) influenza virus are available [12,40], and structural modeling of the NA protein has also been ... See full document

... regions of HA1 ...Zealand, the genetic variants with dual HA (N128D and E377K) and NA (M15I and N189S) mutations predominated in H1N1pdm by June 2010, although at that point there were no major ... See full document

... May 2009 in Osaka, Japan. Total RNA was extracted from each sample and the receptor binding site (RBS) within HA was successfully amplified using One Step ...RT-PCR. The PCR products (369 bp) were ... See full document

... isolates of infected mice between day 1 and 7 ...represented the major variant in the lung during the whole observation ...increase of about 20% in the proportion of ... See full document

... during the second wave and exhibited substitution S203T, which has potential to contribute to antigenic drift as it is located within antigenic site Ca, although its buried position leaves ... See full document

... in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human ...Although the HA stem is highly conserved between ... See full document

... viruses, the ability of gene segments to reassort, the transmission route, and the huge pool of influenza viruses in birds and mammals ensure their continuously changing behavior ... See full document

... variety of mammalian and avian ...transmission of influenza A viruses is not ...envelope hemagglutinin (HA) and neuraminidase (NA) glycoproteins [1], nonstructural proteins NS1 [2,3] and ... See full document

... in the present study. As in the study by Kilander et ...three of our patients. However, all three patients suffered from a mild form of infection, thus our analysis does not support the ... See full document

... Human influenza A viruses undergo antigenic changes with gradual accumulation of amino acid substitutions on the hemagglutinin (HA) ...strong antigenic mismatch between vaccine ... See full document

... development of new technologies for the generation of monoclonal antibodies, the expression of native recombinant antigens as well as improved analyses of protein ... See full document

... The hemagglutinin and the neuraminidase that project from the surface of the influenza A virus undergo frequent antigenic changes. The minor changes, which occur r[r] ... See full document

... discusses the possibilities of using optical measurements for defining the geometric accuracy of gear wheels casts manufactured in the rapid prototyping ...process. The tested ... See full document

... de influenza A, subtipo H1N1, em abril de 2009, representou um grande desafio para a logística de saúde ...na influenza sazo- nal, um número significativo de indivíduos evolui com pneumonia e ... See full document

... find the area of sector the angle made by the chord (that is chord which divides the circle) is ...in the below method we find the ratio of the segments ... See full document

... from the temperature of casting the bronze to the mould on Figure ...From the introduced cross - section of casts from the probe TDAg, it results that it together with ... See full document

... cooling, the crystallisation of cast iron deviates from the equilibrium ...that the austenite gets supersaturated with carbon and chromium, which greatly reduces the temperature ... See full document

... by the institutional review board of Shanghai Public Health Clinical Center with written informed consent obtained from all patients or their ...to the intensive care unit of Shanghai Public ... See full document

... mechanism of modification of these precipitations one should take into account that effect of modification of hypereutectic silumins depends on earlier transition to liquid phase of ... See full document