[PDF] Top 20 Protein Expression and Codon 72 Polymorphism of TP53 Gene in Triple Negative Breast Cancer
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Protein Expression and Codon 72 Polymorphism of TP53 Gene in Triple Negative Breast Cancer
... subgroup of tumor that has received attention is triple-negative breast cancer (TNBC), which presents phenotype of negative estrogen receptor, negative progesterone ... See full document
5
Rev. Bras. Hematol. Hemoter. vol.27 número1
... mutation of the TP53 gene and inactivation of the p53 protein are the most common alterations observed in human ...tumors. In leukemias these alterations are not ... See full document
2
Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines.
... expression of CDKN2A and MTAP; ...deletion of CDKN2A in this cell line but not a deletion of CDKN2B or INK4A genes, which are closely located on the ...case of ... See full document
13
Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model.
... on cancer-associated fibroblasts that will have a broad impact on tumor ...changes in differential expression, as reported above, reflect gene signatures operative within the tumor ... See full document
13
Análise da expressão imunoistoquímica da proteína p63 e de seu valor prognóstico...
... carcinogenesis and, in this scene, the gene TP53 is one of the most associated with malignant ...the TP53, were identified, the TP73 and ...3q and has a proven role ... See full document
174
The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk.
... The TP53 Arg72Pro SNP is a biologically plausible candidate low penetrance genetic risk factor, and its association with breast cancer risk has been investigated by several ...studies. ... See full document
10
TP53 Codon 72 Heterozygosity May Promote MicrosatelliteInstability in Sporadic Colorectal Cancer
... frequency of p53 altera- tions and the majority of its resulting cancers are adenocarcinomas (45, 46) ...4 of TP53 is one of this gene's largest exons, lies close to the central ... See full document
8
Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
... one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic ...development of esophageal and ... See full document
14
Androgen receptor expression in triple-negative breast cancer
... surface protein which, is activated by binding of epidermal growth factor (EGF), through tyrosine-kinase ...EGFR gene amplification has been described in different tumors, especially in ... See full document
80
Int. braz j urol. vol.41 número2
... number of participants per ethnic group is relatively small and the es- timates of race, ethnic group and comparison among groups were restricted to Macuxis, Yano- mamis and “other ... See full document
9
Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures.
... generation of this report Lehmann et al. [59] described a similar strategy of a pooled dataset of TNBC samples with microarray ...The expression profiles of these subtypes are similar ... See full document
11
CDHI promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer
... either of the CDH1 gene methylation [22,32-35] or the abnor- mal expression of E-cadherin in breast cancer progression ...number of studies directly correlating ... See full document
9
How many diseases is triple negative breast cancer: the protagonism of the immune microenvironment
... PD-1 in effector T lymphocytes, inducing nega- tive regulatory pathways that limit the activity of these ...LAG-3 and the secretion of extrinsic immunosuppressing molecules such as interleukin ... See full document
11
Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk
... found in the majority of human tissues, such as in normal and malignant mammary glands, being mainly expressed by stromal and only rarely by epithelial cells (Macias and Hinck ... See full document
8
J. Bras. Patol. Med. Lab. vol.51 número6
... Introduction: Breast cancer is the most common visceral malignancy in women, the leading cause of cancer death among women ...The triple negative subgroup has poor ... See full document
10
Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype.
... date of the primary surgery to the date of relapse or June ...date of the primary surgery to the date of death or June ...probability and overall survival probability were derived from ... See full document
7
Personalized Gene Expression Analyses of SMAD7 and KLF10 In Breast Cancer
... Many cancer researchers use gene expression analysis for differentiation between tumor and normal cells for diagnostic, prognostic and therapeutic ...Most of studies compare ... See full document
7
Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer.
... the in vivo efficacy of MSA and paclitaxel, female SCID-hairless mice implanted with MDA-MB-231 cells were divided into four groups receiving saline solution as control, 3 mg selenium in the ... See full document
7
Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer.
... NF-kB and Twist-1 transcription factors have been demon- strated to play important roles in epithelial-to-mesenchymal transition (EMT), an early and critical step for cancer invasion ... See full document
15
The differences in ultrasound and clinicopathological features between basal-like and normal-like subtypes of triple negative breast cancer.
... different in the two groups based on the chi- squared test ...oriented in patients scanned in the supine position [16,27]. The result of our study demonstrated that an aspect ratio >1 may ... See full document
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