[PDF] Top 20 Protein translocation across the peroxisomal membrane.
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Protein translocation across the peroxisomal membrane.
... displays the membrane topology described previously for Pex5p present in puri- fied rat liver ...is the so-called stage 2 Pex5p. In the absence of exogenous nucleotides or in the ... See full document
18
Characterization of the mechanisms of protein translocation across the mammalian peroxisomal membrane
... all the advances made in recent years, there are still many aspects of this protein import pathway that remain ...regards the quaternary structure of the PEX5-cargo protein complex ... See full document
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Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein
... to the organelle requires Pex5p, the peroxisomal cycling ...multidomain protein involved in a complex network of transient pro- tein-protein ...most peroxisomal proteins en route ... See full document
8
TIP-1 translocation onto the cell plasma membrane is a molecular biomarker of tumor response to ionizing radiation.
... technology. The peptide demonstrated potentials in assessing the tumor responsiveness to radiation and tyrosine kinase inhibitors at the early stage of treatment courses ...models, the peptide ... See full document
12
The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo
... in the absence (lane 1) or presence (lane 2) of 10 µM ...PAGE/autoradiography. The autoradiograph (upper panel) and the corresponding Ponceau S-stained membrane (lower panel) are ...indicate ... See full document
40
Dissecting the function of the SpoIIIJ and YqjG membrane protein insertases during bacterial spore development
... bacterial protein targeting. The bacterial Sec translocon (blue) is composed of SecY, SecE, and ...motor protein on the cytoplasmic ...at the ribosome (light brown) destined for ... See full document
250
Analysis of surface protein expression reveals the growth pattern of the gram-negative outer membrane.
... outer membrane (OM) of Gram-negative bacteria is a complex bilayer composed of proteins, phospholipids, lipoproteins, and ...revealing the molecular pathways underlying protein and lipopolysaccharide ... See full document
10
Widespread protein aggregation across the mouse lifespan
... double membrane that protects the genome and provides an interface for nucleocytoplasmic communication in eukaryotic ...integral membrane protein of the NE, whose precise physiological ... See full document
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PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox-Sensitive Protein
... by the shuttling receptor PEX5 (9), (ii) this receptor accumulates at the peroxisomal membrane in aging cells (7), and (iii) the export of PEX5 from the peroxisomal ... See full document
15
Ubiquination and deubiquitination in the mammalian pex5-mediated peroxisomal protein import pathway.
... of the E2(s) mediating this ubiquitination event was an immediate ...cerevisiae the occurrence of PEX4-dependent monoubiquitination at the conserved N-terminal cysteine of PEX5 had been previously ... See full document
91
The peroxisomal protein import pathway: a functional study of the N-terminal half of PEX5
... A peroxina 5 (PEX5) é um recetor vaivém responsável pelo transporte de proteínas sintetizadas de novo destinadas para a matriz do peroxissoma. Tem uma estrutura modular caracterizada por i) um domínio N-terminal pobre em ... See full document
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A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery
... at the peroxisomal membrane docking/translocation machinery (DTM; Stage 1b) where it becomes inserted (Stage 2) resulting in the release of the cargo protein into ... See full document
37
A single peroxisomal targeting signal mediates matrix protein import in diatoms.
... single membrane bound ...although the bulk of our knowledge about peroxisomes has been generated from only a handful of model ...organisms. Peroxisomal matrix proteins are synthesized cytosolically ... See full document
9
Membrane translocation of IL-33 receptor in ventilator induced lung injury.
... analyze the histopathological changes in the lung. The lung injury score was examined within each field by microscopy, and lung in- jury was scored according to (A) the infiltration or ... See full document
16
Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis.
... Mtb The subcellular localization of native Rv0132c in Mtb was determined by western blotting and immunoelectron microscopy (Text S1), using polyclonal antibodies raised against purified ...Rv0132c. The ... See full document
8
A β-Lactamase based reporter system for ESX dependent protein translocation in mycobacteria.
... of the cell envelope and the known protein export systems of ...for the phospholipid bilayer plasma membrane. The periplasmatic space (PP) contains two electron dense layers of ... See full document
9
Evaluation of the Leptospira interrogans Outer Membrane Protein OmpL37 as a Vaccine Candidate.
... in the prime-boost group, none of the OmpL37 vaccine formulations evaluated in this study induced significant protection against lethal ...in the animal models of leptospirosis [47–48], this was ... See full document
13
The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.
... mycolactone, the necessary and sufficient virulence factor for Buruli ulcer disease ...blocks the production of LPS-dependent proinflammatory mediators post- ...inhibits the production of these, ... See full document
14
Biogenesis of peroxisomal intrinsic membrane proteins: unveiling the role of pex19p.
... with the energetics reported for the in vitro import of rat PMP22 and PMP70 [84, 85] and ...although the latter authors suggest that ATP may stimulate the assembly of the PMP at ... See full document
93
Mapping of the cargo protein membrane translocation step into the PEX5 cycling pathway.
... 2-5). The first and second aliquot (lanes 2 and 3; respectively) received bovine ubiquitin and 3 mM ATP; the third aliquot received GST-Ub and 3 mM ATP (lane 4); and the fourth received GST-Ub and ... See full document
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