[PDF] Top 20 Quantifying the genetic predisposition to a complex disease through genome-wide association
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Quantifying the genetic predisposition to a complex disease through genome-wide association
... of the individual counts after each per-individual QC step, according to disease status, gender and country of origin (note: whenever male and female counts did not add up to the ... See full document
125
Influence of Feature Encoding and Choice of Classifier on Disease Risk Prediction in Genome-Wide Association Studies.
... able to measure hundreds of thousands or even mil- lions of single nucleotide polymorphisms (SNPs) at once, giving rise to a steadily increasing amount of data being generated ...led to an increasing ... See full document
18
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.
... for the SNPs rs8034191 and rs1051730 ...strength, the conservative approach for SNP confirmation that we have used may lead to larger false negative ...with the inconsistent results of ... See full document
8
Quantifying the underestimation of relative risks from genome-wide association studies.
... of the ‘‘missing’’ heritability for common disease actually resides in known GWAS loci and have estimated this deficit for three particular ...likely to be explained by known GWAS loci than has been ... See full document
10
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies
... of the GENEVA consortium under GEI, with additional support provided by the Mid-Atlantic Nutrition and Obesity Research Center (P30 DK072488), and the Offi ce of Research and Development, Medical ... See full document
12
Genome-wide association study of pancreatic cancer in Japanese population.
... with genome- wide significance on chromosomes ...common genetic risk variants with modest effects are likely to play an important role on this complex disease, either ... See full document
7
Gene networks from genome wide association studies for pigs reproductive traits
... The genetic improvement of reproductive traits such as the number of teats is essential to the success of pig ...opposite to most SNP association studies that consider ... See full document
177
Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
... concentration to be associated with variants in the FUT2 gene, which is linked to gut microbial ecology in general, and to Crohn’s disease in ...concentration to be associated ... See full document
10
Integrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies.
... Genome-wide association study has been a productive approach to studying human com- plex diseases in the past decade, yet challenges still remain in both identifying and inter- preting ... See full document
19
A network-based approach to prioritize results from genome-wide association studies.
... Genome-wide association studies (GWAS) are a valuable approach to understanding the genetic basis of complex ...of the challenges of GWAS is the translation ... See full document
12
A genetic predictive model for canine hip dysplasia: integration of Genome Wide Association Study (GWAS) and candidate gene approaches.
... of the most prevalent developmental orthopedic diseases in dogs ...Unfortunately, the success of eradication programs against this disease based on radiographic diagnosis is ...Adding the use ... See full document
13
Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals.
... and complex genetic architecture. Genome-wide association studies (GWAS) have identified several significant loci associated with ...However, the explained heritability is still ... See full document
16
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
... from the customer database of the personal genetics company, 23andMe, ...Inc. The majority of cases were recruited into that database through PD support groups and tertiary ...Parkinson’s ... See full document
14
Prediction of disease and phenotype associations from genome-wide association studies.
... Genome-wide association studies (GWAS) have become a popular method for surveying genetic variations, such as single nucleotide polymorphisms (SNPs) and classifying heritable risk factors ... See full document
10
Exploiting SNP correlations within random forest for genome-wide association studies.
... from the trees where this SNP appears. Another approach proposed in [23] is to use haplotypes instead of SNPs to build RF ...recommend to use the original RF methods together with their ... See full document
11
Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.
... Importantly, the two loci located 4 Mb apart were tagging different risk ...For the combined dataset, the top SNP in each region shows high LD (r 2 > ...within the same peak, but low LD (r ... See full document
24
Efficiency of genome-wide association study in open-pollinated populations
... due to recombination after ten generations of random crosses was beneficial to QTL identification in population 1 – generation ...LD, the GWAS was highly efficient, so the LD becomes ... See full document
59
Statistical power of model selection strategies for genome-wide association studies.
... on the definition of ...performs the best in finding the true underlying genetic model in most of the model space ...of the model space, and it is always better than the ... See full document
14
A genome-wide linkage and association scan reveals novel loci for autism
... for the AGP samples at three centres, namely Gulbenkian, Mt Sinai and Oxford: DNA from 1,629 families representing numerous recruiting sites was genotyped for 54 ...analysis. The next step in our QC process ... See full document
10
A genome-wide linkage and association scan reveals novel loci for autism
... of the minor allele (OR < 1). While the same filters yielded high-quality results for SNPs with over-transmission of the minor allele (λ = ...in the TDT: if missing data are preferentially ... See full document
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