[PDF] Top 20 Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
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Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
... that tempol treatment delayed the motor deficit by 1 week compared to the vehicle-treated ...described, tempol treatment did not show a statistically significant effect on the overall survival ... See full document
15
Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology.
... used in the treatment and prevention of seizures in epilepsy ...models of neurodegenerative diseases showed positive outcomes induced by ketogenic diet such as increased motor ... See full document
10
Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
... ratio of 10% which is widely accepted as biologically ...out of studies due to incorrect genotyping or issues unrelated to development of motor ...males in pairs which increased to ... See full document
12
Chronic Anatabine Treatment Reduces Alzheimer's Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.
... neuroinflammation in Tg PS1/APPswe mice. The transcription factors NFκB and STAT3 play a critical role in the propagation of inflammatory reactions within the CNS and notably ... See full document
21
Dissecting gastrointestinal dysfunction and inflammation in a “pre-motor” rodent model of Parkinson’s disease
... cytokine of increasing interest to gastroenterologists because of its developing role in gastrointestinal ...role in a novel innate immune response since it can be released by signals from an ... See full document
106
Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms.
... progressive dysfunction and death of motor neurons in the motor cortex, brain stem, and spinal ...cause of the disease is unknown in the majority of ... See full document
12
Cardiac Dysfunction in a Porcine Model of Pediatric Malnutrition.
... peptide and cardiac troponin-T were measured ...decreased in both MAIZE and AGE-REF dur- ing the first 3 weeks but increased markedly in MAIZE relative to AGE-REF during week 5–7 ...difference ... See full document
16
ROLE OF MICROGLIA-MEDIATED NEUROINFLAMMATION IN DYSFUNCTION OF BLOOD-BRAIN BARRIER IN GLIOBLASTOMA. Marina Alexandra Moreira do Couto
... role in neuroinflammation acting as the first and main form of active immune defense in the ...state of MG is highly influenced by the surrounding microenvironment (Kofler & ... See full document
82
Trihalomethanes in Liver Pathology: Mitochondrial Dysfunction and Oxidative Stress in the Mouse
... 33% of animals exposed to DBCM or BDCM developed a multifocal necrotizing hepatitis compared with only 20% in the methanol- exposed group and none in the control ...frequent in the DBMC ... See full document
12
Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.
... (IGF-I) and its type I receptor (IGF-IR) play significant roles in tumorigenesis and in immune ...immunostimulation in a breast cancer ...inhibition of in vivo tumor ... See full document
12
Selective APRIL blockade delays systemic lupus erythematosus in mouse.
... IgA and IgM levels. For IgM, anti-dsDNA and anti-chromatin levels, and for IgG, anti- chromatin levels were also affected, constituting a molecular explanation to the disease amelioration ... See full document
8
Coupling of atherosclerosis progression and bone disturbances in a mouse model
... days and then were dehydrated using ethanol at 96% (Proclínica, Lisboa, Portugal) for 24h and ethanol at 100% (VWR, Leicestershire, UK) for ...clearing in which the samples where embedded in ... See full document
129
Nocturnal hypoxia in ALS is related to cognitive dysfunction and can occur as clusters of desaturations.
... consists of 15 nouns that were read to each patient in 5 successive trials (Trials 1–5), followed by free recall, delayed recall, and delayed recognition ...memory and visuospatial function by ... See full document
5
Development and validation of a model of motor competence in children and adolescents
... total of 584 children (boys n = 300) with ages between 6 and 14 years were assessed using nine well known quantitative motor tasks, divided into three major components (stability, locomotor ... See full document
5
Apocynin Dietary Supplementation Delays Mouse Ovarian Ageing
... dewaxed and hydrated as previously described. After washing in PBS, they were mounted in phosphate-buffered glycerol and observed under a fluorescence microscope (Carl Zeiss AxioImager Z1) ... See full document
12
Glia-Motoneuron dialogue in ALS onset and progression in SOD1G93A-mice model
... expression in astrocytes ab- rogated their GluR2-regulating capacity, rendering MNs vulnerable to excitotoxicity (Van Damme et ...release of neurotrophic factors, of which glial-cell derived ... See full document
97
Central Autonomic Dysfunction Delays Recovery of Fingolimod Induced Heart Rate Slowing.
... tion in the seven MS patients who had a delayed HR re-increase after ...Fingolimod-initiation. In comparison to the other 14 patients and the healthy participants, the seven patients had less ... See full document
15
Endothelial Dysfunction and Insulin Resistance as Pathophysiologic Mechanisms in a Rat Model of Preeclampsia
... [r] ... See full document
9
Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages.
... [43] and PLB1-triple [41], there is considerable variability in the pat- terns of these alterations across the light-dark ...observed in TgCRND8 mice is more prominent during the active phase ... See full document
22
[Ventilatory dysfunction in motor neuron disease: when and how to act?]
... Quando o PCF (com LVR e assistência manual) se apro- xima do valor limite de 270 L/min, o risco de insuficiência respiratória grave no contexto de infecção respiratória aumenta exponencialmente. Isto resulta do facto de, ... See full document
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