[PDF] Top 20 1,2,4-triazine derivatives: Synthesis and biological applications
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1,2,4-triazine derivatives: Synthesis and biological applications
... genes and found that two of them (Axin2, Lgr5) were reproducibly activated (9–10 fold) in rat intestinal epithelial cells (IEC-6) following β-catenin stabilization by Wnt-3a ligand ...xanthothricin) and ... See full document
14
Mg(ClO 4) 2 catalyzed Eco-benign synthesis of 1,2,4-triazolinone derivatives as anti-tubercular agents
... annum and up to three million individuals die due to this disease 8 and if this ravage of tuberculosis is left unchecked, there will be about 1 billion more people newly infected with TB till ... See full document
11
A facile one-pot synthesis of 3-(1-Benzyl-2-phenyl-1H-imidazol-4-yl)-4-hydroxy-6-methyl-2H-pyran-2-one derivatives via multi-component approach
... mmol) and ammonium acetate (1.5 mmol) was taken in anhydrous ethanol (4-6 ml), stirred at 110°C for ...r.t. and the product precipitated from water and then recrystallised from ... See full document
7
Synthesis, characterization and biological evaluation of zinc(ii) complexes with phenanthroline derivatives and s-methyl dithiocarbazate schiff bases
... efficacy and improved selectivity is a matter of urgency to multi drug resistance and toxicity problems associated with many therapeutic drugs ...complexes and extensive biological effects ... See full document
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SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NEW PYRAZOLOPYRIDAZINE DERIVATIVES
... of 4-(4-chlorophenyl)-4-oxobutanoic acid (1) with hydrazine hydrate furnished compound ...3a-h; 4-substituted-benzylidene-6-(4-chlorophenyl- ... See full document
7
Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents
... mol) and freshly fused zinc chloride (20 g) was added phosphoryl chloride (50–60 ...for 2–3 h until the starting material had disappeared as controlled by ...ice and allowed to stand ...bicarbonate ... See full document
8
Design, synthesis and biological evaluation of (E)2(2)quinoxalines, a promising and potent new class of anticancer agents
... thesized and evaluated for their activity against four cancer cell lines: potent cytotoxicities were found (IC 50 ranging from ...positions and the type of substituents attached to the aromatic ring are ... See full document
6
One pot synthesis of 2-hydroxy pyrrolidine derivatives
... anilines and cyclic enol ethers such as 2,3-dihydrofuran and 3,4-dihydro-2H-pyran in the straight forward synthesis of tricyclic furo/pyrano tetrahydroquinolines has continued to attract considerable ... See full document
6
Synthesis and antifungal evaluation of imines derived from 3-Amino-2-isopropyl-3H-quinazolin-4-one
... natural and non-natural products have been known for their biological properties, for example, antitumor, 1-4 anti-inflammatory, 5-7 anticonvulsant, 8-11 analgesic, 6,7,12 as well as ...total ... See full document
9
Chitosan: hydrossoluble derivatives, pharmaceutical applications and recent advances.
... principal na ação da quitosana no tocante a tal aspecto. A quitosana é dotada de viscosidade, principalmente em meio ácido. Assim sendo, a ausência de viscosidade em local onde nutrientes são ab- sorvidos, como o ... See full document
10
Synthesis and antimicrobial activities of 5arylidenethiazolidine2,4dione derivatives
... (MIC) and Mini- mum Bactericidal Concentration ...Clinical and Laboratory Standards Institute (CLSI) ...broth and Sabouraud dextrose broth (Difco, USA) at pH 7.4 and the twofold serial ... See full document
9
Synthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groups
... displaced and recorded on an online computer via a four-channel transducer data acquisition system (MP30B-CE, BIOPAC Systems ...of 1 g for 60 min. Ca 2+ free KHS was replaced with fresh solution ... See full document
10
J. Braz. Chem. Soc. vol.18 número2
... coumarin derivatives, esculetin-4-carboxylic acid methyl ester (1) and esculetin-4- carboxylic acid ethyl ester (2), have been isolated from the marine sponge Axinella ...data ... See full document
4
J. Braz. Chem. Soc. vol.28 número4
... produced 2-amino-alkyl-1,2,3-triazole-1,4-NQ derivatives in an overall yield of 45-76% in four ...linear synthesis (Strategy A) was chosen to prepare ... See full document
8
Synthesis, Anti-Inflammatory and Anti- Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors
... toxicity and their potential to increase the risk of ...Materials and Methods: In this study, three novel analogues of thiazolidin-4-ones derivatives 2a-c were ...COX-1 and ... See full document
7
3-Hydroxy-quinolin-2(1H)-ones, a useful scaffold : synthesis and biological evaluation
... afeta 1 em cada 10000 nados-vivos na Europa, é caracterizada por elevadas concentrações fisiológicas de Phe, devido à atividade deficiente da fenilalanina ...de 4-carboxamida-F3CO-3HQs foi sintetizada e ... See full document
233
A Convenient Synthesis, Reactions and Biological Activity of Some New 6H-Pyrazolo[4’,3’:4,5]thieno[3,2-d][1,2,3]triazine Compounds as Antibacterial, Anti-Fungal and Anti-Inflammatory Agents
... chloropyrazole 1 in the presence of sodium borohydride to give the non-isolated sulfanyl sodium salt 3, which was subjected to react in situ with chloroacetonitrile to afford the pyrazolesulfanyl acetonitrile ... See full document
14
Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives
... of 4-piperidone hydrochloride monohydrate (1, 10 mmol) and various substituted aromatic aldehydes (20 mmol) in ethanol (10 mL) was stirred at room temperature (29 °C) for 10 ...filtered and ... See full document
12
Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis
... tubes and the reaction monitored by ...nitrogen and formation of iminoaziridines 40-42, in yields above 80%, and a minor photofragmentation channel leading to N,N- dialkylcarbodiimide and ... See full document
18
Low Generation Triazine-based Dendrimers - Synthesis, Characterization and in Vitro Biological Activity
... (Solution 1) was prepared and a solution of TEG ...salt and ice was used to control the temperature) (Solution ...filtered, and the obtained white solid was washed with 20 ml of ...hexane ... See full document
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