[PDF] Top 20 Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
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Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
... chronic hepatitis C is to achieve a sustained virological response, which is defined as ex- hibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy ... See full document
5
Predictors of early treatment discontinuation and severe anemia in a Brazilian cohort of hepatitis C patients treated with first-generation protease inhibitors
... discontinuation and severe anemia among patients with chronic hepatitis C virus (HCV) genotype 1 infection, treated with first-generation protease inhibitor ... See full document
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Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss.
... on the resistance phenotype. Furthermore, the effect on RC was far less pronounced than that of the total removal of patient-derived Gag sequences, as seen in XS ...clones. In ... See full document
11
Development of elvitegravir resistance and linkage of integrase inhibitor mutations with protease and reverse transcriptase resistance mutations.
... First, the study was limited to a small number of patients with significant prior ARV exposure, multiple pre-existing DRMs, and suboptimal response to the EVG-containing ...is ... See full document
10
HCV Genotypes, Characterization of Mutations Conferring Drug Resistance to Protease Inhibitors, and Risk Factors among Blood Donors in São Paulo, Brazil
... genetic variability and is classified into seven major genotypes and over 100 subtypes that vary with regard to their geographic distribution, risk factors associated with infection, ... See full document
9
Genetic diversity of NS3 protease from Brazilian HCV isolates and possible implications for therapy with direct-acting antiviral drugs
... that the Bra- zilian subcluster inside clade 1 had different phenotypic characteristics in relation to the presence of resistance mutations for macrocyclic inhibitors (MK-7009, ... See full document
8
Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.
... that the C4 cleavage site of HCV NS3/4A protease is between either Cys-1583 and Ser-1584 or Cys-1590 and Ala-1591 of C4, both of which are located in the C4 chain (Figure ... See full document
7
NS3 protease from flavivirus as a target for designing antiviral inhibitors against dengue virus
... by the four antigenically distinct dengue virus serotypes, ...that the two virus-encoded non-structural proteins NS3 and NS5 that contain the key enzymes re- quired for ... See full document
6
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil
... morbidity and mortality related to human immunodefi - ciency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral sus- ceptibility, thus contributing to ... See full document
12
Natural Polymorphisms Conferring Resistance to HCV Protease and Polymerase Inhibitors in Treatment-Naive HIV/HCV Co-Infected Patients in China.
... chronic hepatitis C virus (HCV) infection has brought this global pandemic to the forefront of public health attention ...Co-infection with HIV is common in HCV patients ... See full document
14
Avaliação da resistência do HIV-1 às drogas anti-retrovirais em 150 pacientes em...
... Changes in guidelines for antiretroviral introduction and difficulties in maintaining Highly Active Antiretroviral Therapy have lead some physicians in Brazil to interrupt for long periods of ... See full document
110
Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.
... study, the effect of pharmacological inhibition of lysosomal proteases on β-cell death was ...cultured in the presence of lysosomal protease inhibitors in 11 mM glucose (normal ... See full document
18
A Novel Adeno-Associated Virus-Based Genetic Vaccine Encoding the Hepatitis C Virus NS3/4 Protein Exhibits Immunogenic Properties in Mice Superior to Those of an NS3-Protein-Based Vaccine.
... of the transfection solution was gently added to each dish. The plates were swirled slowly to mix the contents, then returned to the ...transfection, the medium was replaced with ... See full document
15
Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.
... [27], the papain-like protease domain in nsp3 [17], nucleocapsid protein [28,30], membrane protein [29] and the products of open reading frame 6 (ORF6) and ORF3b ...croup ... See full document
11
Clinical and Biochemical Evaluation of HIV-Related Lipodystrophy in an Ambulatory Population from the Hospital Universitário Cassiano Antonio de Morais, Vitória, ES, Brazil
... associated with HIV-1 related lipodystrophy at a tertiary HIV-care center in Vitória, ES, ...therapy and age above 17 ...initially the exposure variable, but a second analysis was also ... See full document
5
Trypsin-like serine proteases in Lutzomyia longipalpis--expression, activity and possible modulation by Leishmania infantum chagasi.
... prepared in dimethyl sulfoxide (DMSO). The reaction was started by the addition of the equivalent to ...midguts, in a total volume of 200 m L of 10 mM Tris-HCl pH ...(DMF), and ... See full document
8
YMDD motif mutations in chronic hepatitis B antiviral treatment naïve patients: a multi-center study
... B virus (HBV) is a leading cause of liver diseases worldwide, and china has a high prevalence of HBV ...adefovir, and entecavir have been developed for the treatment of chronic ... See full document
6
Diagnosis, antiretroviral therapy, and emergence of resistance to antiretroviral agents in HIV-2 infection: a review
... antiviral resistance suggest that the pattern of HIV-2 RT mutations after exposure to NRTIs is less well defined than for HIV- ...genotypic and phenotypic analysis of HIV-2 clones obtained ... See full document
9
Geographic distribution of hepatitis C virus genotypes in Brazil
... Reverse and forward strand sequences were aligned and a consensus sequence was obtained for each ...case. The consensus se- quence was then compared with the se- quences of all HCV ... See full document
9
Major Article First-wave protease inhibitors for hepatitis C genotype 1 treatment: a real-life experience in Brazilian patients
... chronic hepatitis C treatment in 2011, the protease inhibitors (PIs) telaprevir (TVR) and boceprevir (BOC), which have high sustained viral responses (SVR), ushered a new ... See full document
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