[PDF] Top 20 In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
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In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
... forms of the para- site (Mady et ...production of free radicals by a metabolic ...levels of activity in the parasite, T. cruzi is highly susceptible to the damage that is induced ... See full document
6
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of a Novel Nitro-derivative
... by Trypanosoma cruzi (WHO 1993), the causative agent of this ...made in the control of vectorial and transfusion transmission of the disease, through spraying programs to ... See full document
5
Daniel Sol Sol de Medeiros [1],[2],[3] , Ana Fidelina Gómez Garay [2],[3],[4], Jorge Alfonso Ruiz Diaz [2],[3],[4] , Maria Celeste Vega Gómez [4], Carolina Bioni Garcia Teles [1],[2],[5],[6] and Leonardo de Azevedo Calderon
... limitations. Activity of cinnamic acid analogs against Leishmania ...spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new ... See full document
5
REPOSITORIO INSTITUCIONAL DA UFOP: Ravuconazole self-emulsifying delivery system : in vitro activity against Trypanosoma cruzi amastigotes and in vivo toxicity.
... diameter of the fractions were determined with a PN3621 multiangle laser light scattering (MALLS) detector with a 532 nm laser (7°–164°, 21 angles), and the hydrodynamic diameter with a Zetasizer Nano ZS (Malvern ... See full document
15
Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi
... action of diamidines, which is a very impor- tant characteristic in situations of acute cases of reactivation under conditions of immunosuppression ...protocol, in which com- ... See full document
7
In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)
... trypanocidal activity exhibited by the essential oil from ...identified in the essential oil from different species of Lippia spp, with recognised antiparasitic activity (Escobar et ...found ... See full document
9
Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
... One of the advantages of repositioning FDA-approved drugs is the existing medical data on the drug, including dosing, side-effects, tolerance profiles and the pharma- cokinetic and pharmacodynamics ... See full document
12
Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi
... effects against all developing stages of ...T. cruzi. These appears to be an interesting attribute of these class of compounds, if we consider that several other diterpenoids ... See full document
6
Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi
... exception of the anthracyclines aclarubicin and idarubicin, all other DNA topoisomerase inhibitors displayed no activity against ...trypanocidal activity (Fig. 1) with GI 50 values in ... See full document
5
CH-3 ACTIVITY OF 7-EPICLUSIANONE AGAINST BLOOD TRYPOMASTIGOTES OF TRYPANOSOMA CRUZI
... treatment of leishmaniasis there has been a major emphasis on biochemical and molecular targets, for example trypanothione reductase and cysteine proteases, and the identification of inhibi- tors by ... See full document
25
Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal
... number of compounds with anti-parasitic ...bark of the cinchona tree (Cinchona ...used in malaria treatment in artemisinin-combination ...Prize of Physiology and Medicine 2015 ... See full document
7
Estudo fitoquímico e avaliação in vitro da atividade anti-Trypanosoma cruzi cepa Y de Pilocarpus spicatus St. Hil. (Rutaceae).
... and in vitro evaluation of the anti-Trypanosoma cruzi Y strain activity of Pilocarpus spicatus ...investigation of the species Pilocarpus spicatus – popularly known ... See full document
7
Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.
... (400 compounds / batch) assay to predict cidality of com- pounds against intracellular ...load in the cells resulting from extending the time after infection before compound exposure and the ... See full document
19
Rev. bras. farmacogn. vol.18 número2
... Bioactivity of fractions and compounds obtained from Polygala sabulosa against Trypanosoma cruzi epimastigote, blood trypomastigote and amastigote forms were evaluated in ... See full document
6
Antitrypanosomal acetylene fatty acid derivatives from the seeds of porcelia macrocarpa (annonaceae)
... occurrence of acetylene acetogenins in the seeds was also reported ...part of our ongoing studies devoted to the investigation of the antiparasitic compounds from Brazilian plants [13 ... See full document
13
Advances in nanocarriers as drug delivery systems in Chagas disease
... trypanocidal activity, but its hydrophilic struc- ture causes slow diffusion through the ...membrane. In this context, in 2005, Morilla et al 52 used pH-sensitive liposomes to encapsulate ETZ ... See full document
18
Synthetic oxoisoaporphine alkaloids: in vitro, in vivo and in silico assessment of antileishmanial activities.
... number of cases (LLPIs and nLLPIs) used to train the ...accuracy of 95.2% in training and of 94.8% in external validation series (Table ...development of an accurate model ... See full document
8
In vitro effects of citral on Trypanosoma cruzi metacyclogenesis
... h in TAU3AAG medium with 40 µg/mL citral. Although most cells in the supernatant of the control medium displayed the characteristic morphology of metacyclic trypomastig- otes, most cells ... See full document
7
Avaliação da atividade antiparasitária do alopurinol, referente ao Trypanosoma cruzi, em sistema experimental que utiliza triatomíneos infectados.
... ao Trypanosoma cruzi, através de procedimento que depende da utilização de triatomíneos ...T. cruzi, porquanto ela continua em foco, se bem que eivada de divergências e ... See full document
3
Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites
... Guer- in PJ, Dondorp AM, Day NP, White NJ, Tracking Resistance to Artemisinin Collaboration ...Spread of artemisinin resistance in Plasmodium falciparum ... See full document
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