J. Braz. Chem. Soc. vol.25 número10

There were many examples of diseases in this second group of diseases—diseases that are not rare, but are neglected; they are often concentrated in diseases—and especially

A screening of approximately 12,000 small-molecular- weight compounds resulted in the selection of guanidine derivatives, such as 11 (Figure 2), as competitive inhibitors

Currently, he is a Professor at the Faculty of Pharmacy, Federal University of Pará (UFPA, Brazil) and worked in development of drug, drug toxicity and oxidative stress

Based on current knowledge of parasite and host biological characteristics, a desired drug candidate for Chagas disease would include the following attributes: ( i ) high

As shown in this revision of our current knowledge on the potential of chemical manipulation of insect behavior vectoring human diseases, there is an arsenal available that

for the treatment of Chagas disease should fulfill several requirements: ( i ) The drug should show parasitological cure for both the acute and the chronic phase; ( ii ) it has to

Validation parameters of the developed HPLC method for simultaneous determination of sesquiterpene lactones in the dichloromethane fraction of the hydroalcoholic extract obtained

Comparing the IC 50 values for compounds ( 2 - 6 ) the potency of gallic acid ( 2 ) is more significant, but increasing the galloyl groups in the quinic acid moiety ( 3 - 6 )