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In-silico patterning of vascular mesenchymal cells in three dimensions.

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Academic year: 2017

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Figure 1. Diagram showing interactions between BMP-2, MGP, and cells in culture. The binding of a BMP-2 dimer to receptors R and S stimulates production of BMP-2 and MGP, while the inding of MGP to BMP-2 outside of the cell prevents this process
Fig. 4 shows the evolution of cells with an initial condition of a (a) spherical or (b) cylindrical region along the center axis containing at 2 6 higher BMP-2 concentration than the steady state
Figure 3. 3D steady state patterns of cells. The derived model shows spherical spots(k = 0.2,c = 0.12), tubes(k = 0.2,c = 0.04), and sheet-like structures(k = 0.8,c = 0.04) by varying k and c
Figure 4. Initial and steady state patterns of cells produced by exogenous BMP-2. An initial condition of 26higher concentration of BMP-2 is placed along the center (a) sphere or (b) cylinder and the cells are allowed to reach steady state

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