Allogeneic stem cell therapy
Characteristics of two conditioning regimens cyclophosphamide plus antithymocyte globulin versus cyclophosphamide plus busulfan in allogeneic stem cell transplantation for severe aplastic anemia
... myeloablative therapy at the time of transplant for various reasons (delay in results of chromosome stability and fragility in one patient and abnormal pulmonary function in the second), had a non-myeloablative ...
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PLASMATIC TNF-alpha, IL-2, IFN-gamma and IL-10 ARE IMPORTANT CYTOKINES TO CONTROL CML AFTER ALLOGENEIC STEM CELL TRANSPLANT
... Prolonged courses of high dose steroids are frequently used to manage graft vs. host disease (GVHD) following allogeneic stem cell transplant (SCT). Among the known complications of pro- longed ...
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Muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease.
... one therapy for the malignant disease prior to allo-HSCT (chemotherapy, n = 21; monoclonal antibodies, n = 8; autologous HSCT, n = 9; irradia- tion, n = 4; cytokine therapy, n = ...neurotoxic therapy ...
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Allogeneic hematopoietic stem cell transplantation from an alternative stem cell source in Fanconi anemia patients: analysis of 47 patients from a single institution
... Since the HSCT is the only way to restore normal hematopoiesis and improve survival of FA patients with hematological manifes- tation of the disease, efforts have been made to search for a methodology capable of ad- ...
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How Allogeneic Hematopoietic Stem Cell Transplantation has Evolved Over Time: 30-Years’ Experience at a Single Institution
... chemo- therapy allowing for more patients being brought to trans- plant, better definition of patients who may benefit from a transplant, acceptance of older patients in our program and the availability of better ...
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Outcomes of allogeneic stem cell transplantation among patients with acute myeloid leukemia presenting active disease: Experience of a single European Comprehensive Cancer Center
... The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood. 1998; 92(7):2322-33. 5. Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, ...
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Correlation of mixed lymphocyte culture with chronic graft-versus-host disease following allogeneic stem cell transplantation
... genitor cells (PBPC). In the evaluation of acute GVHD, 25 patients were excluded from the analysis because 18 had died with- out acute GVHD and 7 had received marrow reinfusion before day 100, and in the evalu- ation of ...
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Efficacy of Mesenchymal Stem Cell Therapy for Steroid-Refractory Acute Graft-Versus-Host Disease following Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.
... At present, little is known about the mechanisms by which MSCs inhibit GVHD. In vitro, MSCs have varied effects on immune cells, including T cells, antigen-presenting cells, natural- killer cells, and B cells [46–48]. ...
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Stem and progenitor cell-mediated tumor selective gene therapy
... to allogeneic cell lines, we note that in a murine model of metastatic neuroblastoma, the immu- nosuppressive agent cyclosporin did not affect the tumor-tropic properties of the ...from allogeneic ...
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Characteristics of Human Natal Stem Cells Cultured in Allogeneic Medium
... pulp stem cells (hNDP-SCs) have been characterized in vitro and it has been shown that they satisfy criteria defining human mesenchymal stromal cells (MSCs), as proposed by the International Society for Cellular ...
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Cryopreservation and Thawing Protocol of Mesenchymal Stem Cells for use in Veterinary Medicine Cell Therapy
... In nature, there appears to be a reverse relationship between complexity and regenerative ability; the more complex the organism, the more decreased its capacity for regeneration is. Tissue and organ regeneration in ...
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Stem cell therapy of cataract
... Research has been conducted to find ways to treat cataract. Cell and tissue- based therapeutic procedures are new strategies for this purpose. O’Connor et al in 2007 showed that the lens epithelial pieces that ...
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Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice.
... Further studies are certainly needed to elucidate molecular and cellular mechanisms that govern the differentiation of UMSCs within the stroma of recipient Lum -/- mice. For example, does the improved organization of the ...
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Mesenchymal stem cells for the cell-based therapy of type 1 diabetes : an experimental approach
... beta cell membrane auto- antigen that contributes to the autoimmune reaction in T1D and ...beta cell from ongoing immune destruction and sustain insulin secretion without causing immunosupression 113 ...
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Stem Cell in Breast Milk
... Similar to other sciences, operative dentistry has been using regenerative approaches to treat.. dental disease.[r] ...
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Towards cardiac cell therapy
... distinct cell surface receptors, encoded in four different genes Fgfr1-4, that, through alternative splicing events, can produce many single-pass transmembrane receptor isoforms, belonging to the RTK family of ...
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Bioprocessing of human Pluripotent Stem Cells for cardiac cell therapy and pre-clinical research
... higher cell lysis was observed during all culture time, suggesting that this agitation profile may have induced high shear rate for cells, compromising cell viability, proliferation capacity and ...
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Spermatogonial stem cell niche and spermatogonial stem cell transplantation in zebrafish.
... obtained cell suspension was immediately submitted to FACS (Fluorescence Activated Cell Sorting) using an inFlux cell sorter (BD Bioscience, San Jose, CA, USA, ...germ cell type in zebrafish ...
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Incidence of ventricular arrhythmias after stem cell therapy in patients with Chagas cardiomyopathy
... The sample consisted of 60 patients included in the abovementioned protocol from April 2006 to November 2009, followed for at least 1 year after randomization. This was a convenience sample. Inclusion criteria were: ...
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Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics
... Intervertebral disc (IVD) degeneration is a major cause for neck and low back pain and as such a signiicant public health problem. According to the Global Burden of Disease Study, published in The Lancet in December ...
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