cathepsin B
Cathepsin B & L are not required for ebola virus replication.
... proteases Cathepsin B and L (CatB, CatL), which have been shown to cleave ZEBOV-GP leading to subsequent exposure of the putative receptor-binding and fusion domain and productive ...
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Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress.
... of cathepsin B ...blocking cathepsin B activity, z- FA-FMK effectively blocked human T cell activation and proliferation in vitro, and modulates host response to pneumococcal infection in vivo ...
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Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge.
... Cells in the trabecular meshwork (TM), a tissue responsible for draining aqueous humor out of the eye, are known to be highly phagocytic. Phagocytic activity in TM cells is thought to play an important role in outflow ...
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2-chlorovinyl tellurium dihalides, (p-tol)Te[C(H)=C(Cl)Ph]X2 for X = Cl, Br and I: variable coordination environments, supramolecular structures and docking studies in cathepsin B
... Br (2) and I (3), is within a distorted Ψ-pentagonal bipyramidal geometry. An E coniguration for the vinyl group in (1) precludes the formation of an intramolecular Te…Cl interaction so that an intramolecular Te…π ...
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A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis.
... Cathepsin B (CTSB) is a proteolytic enzyme potentially modulating angiogenic processes and extracellular matrix remodeling. While matrix metalloproteinases are shown to be implicated in tissue fibrosis and ...
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Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.
... from cathepsin B-deficient mice express higher levels of MHC class II molecules in comparison with BMDC from cathepsin L-deficient and WT mice, but no differences were observed in the expression of ...
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Cathepsin S contributes to the pathogenesis of muscular dystrophy in mice
... FIGURE 2. Loss of Ctss in mdx mice attenuates disease pathogenesis. A,B, Western blot analysis for Ctss protein and (B) Ctss, cathepsin B (Ctsb) and cathepsin L (Ctsl) activity from the ...
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Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver
... not vary (or presented a transitory and slight decrease). There were no apparent changes in liver morphology, and immunohistochemistry revealed the presence of cathepsin B in hepatocyte granules. The ...
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A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.
... Biosciences), cathepsin D (goat polyclonal, 1:1000; R&D Systems, recognizing pro-cathepsin D (52 kDa), an active intermediate (48 kDa) and the heavy chain of active cathepsin D (34 kDa)), ...
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Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.
... Endoscopic techniques have provided sensitive means of detecting adenomatous polyps that could potentially progress to colon cancer. Thus, endoscopic monitoring of susceptible individuals has made it possible to detect ...
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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis.
... a-synuclein dysregulation is a critical aspect of Parkinson’s disease pathology. Recent studies have observed that a- synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between ...
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Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.
... as cathepsin B, K, and L, whereas pepstatin A has inhibitory effects on aspartic proteases such as cathepsin D and ...of cathepsin B and L, but not cathepsin K, also in- creased ...
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Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts
... evaluate cathepsin X catalytic activity in conditioned media of primary osteoblasts ...ng cathepsin X also hydrolysed the substrate, but not as efficiently as the pOB-condi- tioned ...Pre-activated ...
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Sao Paulo Med. J. vol.133 número1
... Statistical analysis was performed using the SPSS 16.0 sotware for Windows (SPSS, Chicago, Illinois, USA). he Kolmogorov- Smirnov test was used to analyze whether the data had normal dis- tribution, and the study ...
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Cathepsin BX is secreted by Echinometra lucunter sea urchin spines, a structure rich in granular cells and toxins
... SDS-PAGE (10%) was used to separate proteins of the spine extract (10 μg, determined by Bradford assay), according to the method described by Laemmli [17], and subsequently transferred onto nitrocellulose membranes. ...
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Particle size of latex beads dictates IL-1β production mechanism.
... of cathepsin B into cytosol and subsequent NLRP3 activation followed by IL-1β production ...induces cathepsin B- dependent IL-1β production of BMDM, being accompanied by lysosome swelling, ...
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Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases.
... that cathepsin L and B are likely involved in ABCA3 ...of cathepsin B against ABCA3 is not very ...sin B, it turned out that the cell permeable CA-074Me also inhibits cathepsin L ...
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Base maior Base menor Altura
... Matemática B, os alunos de uma turma da Escola Secundária APRENDERMAIS desenvolveram um trabalho de projecto que incluía um estudo sobre a intenção dos jovens da sua região, que frequentavam o ensino secundário, ...
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B AHIA ,B RASIL
... geograficamente) pela forma e dimensões da lâmina, indumento tomentoso e pelos estiletes ar queados. S ão no entanto , f acilmen te diferenciadas pela forma das pétalas: em H. jardimii, a pétala posterior apresenta ...
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