Cathepsin L
Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica.
... various cathepsin L clades clearly demonstrates divergence within the S2 subsite, in particular at the three positions that have the greatest influence on P2 binding ...human cathepsin K, the only ...
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Comparative assessment of ELISAs using recombinant saposin-like protein 2 and recombinant cathepsin L-1 from Fasciola hepatica for the serodiagnosis of human Fasciolosis.
... and cathepsin L-1 (recCL1), were assessed individually and in combination in enzyme-linked immunosorbent assays (ELISA) for the specific serodiagnosis of human fasciolosis in areas of low endemicity as ...
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Boophilus microplus cathepsin L-like (BmCL1) cysteine protease: Specificity study using a peptide phage display library
... Previously, Renard et al. (2000) cloned and expressed an R. microplus cathepsin L-like enzyme named BmCL1. The recombinant enzyme was able to hydrolyze natural sub- strates such as tick vitellin, bovine ...
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Digestive physiology and characterization of digestive cathepsin L-like proteinase from the sugarcane weevil Sphenophorus levis
... Sugarcane is an important crop that has recently become subject to attacks from the weevil Sphenophorus levis, which is not efficiently controlled with chemical insecticides. This demands the development of new control ...
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Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.
... procathepsin L and of Schistosoma mansoni (Sm) procathepsin B mediate zymogen destabilization and its subsequence activation ...human cathepsin L, mature Sm cathepsin B, and mature human ...
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Towards delineating functions within the fasciola secreted cathepsin l protease family by integrating in vivo based sub-proteomics and phylogenetics.
... Peptides sequenced during MSMS analysis in conjunction with the F. hepatica EST database yielded a novel Cat L protease sequence. Several of the EST sequences were found to be only partial sequences. Of these ...
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Recognition of higher order patterns in proteins: immunologic kernels.
... than cathepsin L and S can deliver the shorter ‘‘kernel’’ peptides, perhaps depending on cell type ...by cathepsin S or L down to a 9-mer. We note that as cathepsin S may be upregulated ...
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Cathepsin S contributes to the pathogenesis of muscular dystrophy in mice
... FIGURE 2. Loss of Ctss in mdx mice attenuates disease pathogenesis. A,B, Western blot analysis for Ctss protein and (B) Ctss, cathepsin B (Ctsb) and cathepsin L (Ctsl) activity from the quadriceps of ...
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EXPRESSION OF SCHISTOSOMAL CATHEPSIN L1 IN Escherichia coli AND EVALUATION OF ITS PROTECTIVE CAPACITY IN AN ANIMAL CHALLENGE Miyasato PA (1), Ramos CRR (2), Abreu PAE (3), Dias WO (2), Nascimento C (1), Ho PL (2), Kawano T (1)
... cathepsins L-like sequences with ...peregrina cathepsin L protein (SmSP) is, in fact, identical or close related to SmCL3 sequence recently deposited in the databanks (unpublished results, accession ...
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Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.
... from cathepsin B-deficient mice express higher levels of MHC class II molecules in comparison with BMDC from cathepsin L-deficient and WT mice, but no differences were observed in the expression of ...
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Cathepsin B & L are not required for ebola virus replication.
... attachment factors seem to facilitate EBOV entry [3], so far no specific cell surface receptor molecule has been identified. Recently, it was shown that the cholesterol transporter Nie- mann-Pick C1 (NPC1) is required ...
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Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases.
... that cathepsin L and B are likely involved in ABCA3 ...of cathepsin B against ABCA3 is not very ...inhibits cathepsin L to some extent ...between cathepsin B and cathepsin ...
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Genetic diversity and molecular survey of Trypanosoma (Megatrypanum) theileri in cattle in Brazil’s western Amazon region
... In Brazil, the extensive geographical area used for animal husbandry and the intense internal flow of animals favor the contact and transmission of T. theileri and allows genetic events that increase the parasites ...
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Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose.
... as cathepsin B, K, and L, whereas pepstatin A has inhibitory effects on aspartic proteases such as cathepsin D and ...of cathepsin B and L, but not cathepsin K, also in- creased ...
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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis.
... a-synuclein dysregulation is a critical aspect of Parkinson’s disease pathology. Recent studies have observed that a- synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between ...
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Particle size of latex beads dictates IL-1β production mechanism.
... Figure 4. ROS generation and mitochondrial damage are caused by 1,000 nm LxB. (A) After stimulation with LxB (1,000 nm; 0.06%, 20 nm; 0.02%) ± LPS for 1 h in stirred culture, BMDM (BALB/c) were incubated with 10 µM of ...
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Sao Paulo Med. J. vol.133 número1
... Figure 2. Analysis on plasma heparanase-1 activity by quantiication of degraded heparan sulfate. Heparanase-1 enzymatic activity in plasma samples was measured by means of an ELISA-like method, using 15% biotinylated ...
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[Resenha a:] GALASTRI, L. Gramsci, Marxismo e Revisionismo. Campinas: Autores Associados, 2015 — Outubro Revista
... O recorte escolhido por Galastri nos escritos de Sorel foi principalmente a fase do sindicalismo revolucionário e seus desdobramentos nas noções de greve geral e mito, período mais imp[r] ...
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Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver
... Dr. Maria A. Juliano) (17) as substrates. These substrates were used to quantify total cysteine proteases and ca- thepsin B, respectively. Incubation was carried out in dark microplates (Corning, USA), in 50 mM phosphate ...
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