COMMON VARIANTS
Utilizing mutual information for detecting rare and common variants associated with a categorical trait
... multiple variants (Dawy et ...genetic variants is computed through genotype patterns. For m genetic variants, there are 3 m probable realizations of genotype ...when common variants are ...
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Individual common variants exert weak effects on the risk for autism spectrum disorderspi
... of common variation to the risk of developing ASD is less ...that common variants, en masse, might affect the ...of common alleles to Stage 1 cases significantly predict case status in the ...
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Assessing methods for assigning SNPs to genes in gene-based tests of association using common variants.
... to common SNPs ...causal variants will improve power and reduce multiple testing penalties, these methods have generally performed poorly in ...causal variants. Furthermore, we found that the ...
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Common variants on cytotoxic T lymphocyte antigen-4 polymorphisms contributes to type 1 diabetes susceptibility: evidence based on 58 studies.
... Several meta-analyses addressing the same theme have been recently published [70–72]. However, Chen et al. and Si et al. mainly focused on the G49A polymorphism without assessing the relationship between CTLA4 C60T ...
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Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population.
... of common causes of disease among different ...These variants may act as regulatory elements for LBX1, affecting the quality and quantity of LBXI mRNA ...disease-causing variants. Functional analysis ...
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Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis.
... the same in Indian CP patients of Indo-European ethnicity. CLDN2 gene codes for protein claudin-2 that lies in tight junctions and immunohistochemical staining showed weak but membrane-bound expression in acinar, ductal ...
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Research article Association of common variants in mismatch repair genes and breast cancer susceptibility: a multigene study
... a mutator phenotype by which the rate of spontaneous mutation is greatly elevated. A characteristic of MMR-defi- cient cells is instability at microsatellite regions consisting of mono- and di-nucleotide repeats. MSI is ...
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Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.
... FTO variants observed effect sizes and contribution in variance of adiposity traits in Indian children are higher than South Asian ...FTO variants on BMI variance in children ...FTO variants have ...
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Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
... our results due to population stratification. For this reason as the genetic background was expected to be the same in both studies we decided the pooled strategy over other strategies such as meta- analysis in order to ...
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Common variants related to serum uric acid concentrations are associated with glucose metabolism and insulin secretion in a Chinese population.
... This study has some limitations. First, we cannot exclude the possibility of a false positive in our findings when analysed multiple traits and SNPs in this study. As these 14 SNPs were origi- nally identified and ...
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Common variants on chromosome 9p21 are associated with normal tension glaucoma.
... several common diseases (coronary artery disease [76], type 2 diabetes [76], aortic aneurysm [77], intra-cranial aneurysm [76], endome- triosis [78], glioma [79,80]) have revealed associations with this long ...
8
A robust GWSS method to simultaneously detect rare and common variants for complex disease.
... disease-associated variants with a better solution, in particular for low-frequency ...both common and rare variants might exert their independent effects on the risk for the trait of interest, ...
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Networks of neuronal genes affected by common and rare variants in autism spectrum disorders.
... by common variations? Third, do rare and common variations converge on the same molecular pathways or do they represent diverse biological etiologies? Lastly, can we integrate the gene network with GWAS ...
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Rare structural variants in severe spermatogenic impairment
... includes common variants or copy number polymorphisms (CNP), occurring with an overall frequency of greater than ...rare variants which occur in less than 1% of the ...structural variants in ...
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Genetic variants associated with ectopic calcifications
... Nonetheless, variants that showed significant association, in both genes, are located in non-coding regions and are very common variants within the general population, which suggests that these ...
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Genetic association study of common mitochondrial variants on body fat mass.
... that common variants in mtDNA are associated with several common complex diseases, including ...that common mtDNA variants influence obesity-related phenotypes, including BMI and body ...
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Challenging some common beliefs
... Recently, Bröder and Schiffer (2006a) reported results which qualify the optimistic notion of adaptivity docu- mented by the filled circles in Figure 1. Three of the open squares in the figure do not fit into the ...
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Disscusion on the common
... Za tego rodzaju przeświadczeniem kryje się rozumowanie typowe dla kry- tyki ekonomii politycznej, która poszła dalece do przodu za sprawą badaczy pokroju Marazziego, Vercellonego i im p[r] ...
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Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.
... Multiple sclerosis (MS) is the most common neurological disease of young Caucasian adults. Oligodendrocytes are the key cell type damaged in MS, a process that is accompa- nied by loss of the myelin sheath that ...
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