Drug-induced liver injury
Polymorphisms in CTLA4 influence incidence of drug-induced liver injury after renal transplantation in Chinese recipients.
... with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) ...for drug-induced liver ...immunosuppressive drug-induced liver ...
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Sex bias in experimental immune-mediated, drug-induced liver injury in BALB/c mice: suggested roles for Tregs, estrogen, and IL-6.
... To determine if estrogens increase the severity of experimental, immune-mediated DILI, we first immunized BALB/c ovariecto- mized mice. Hepatitis histology scores were similar in ovariecto- mized and non-ovariectomized ...
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Tuberculosis and hepatic steatosis are prevalent liver pathology findings among HIV-infected patients in South Africa.
... had liver biopsy at a single hospital in South Africa from 2001 to 2009 and compared diagnosis by HIV ...had liver biopsy, 108 (41%) were HIV-infected, 25 (10%) were HIV-sero-negative, and 129 (49%) had ...
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DIFFERENT MODELS OF HEPATOTOXICITY AND RELATED LIVER DISEASES: A REVIEW
... cause liver injury are called ...in liver, which have the ability to interconnect with cellular macromolecules such as protein, lipids and nucleic acids, leading to protein dysfunction, lipid per ...
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Hepatoprotective effect of Alhagi sparsifolia against Alcoholic Liver injury in mice
... herbal drug (Jian et ...and liver disorders (Shaker, Mahmoud, Mnaa, 2010; Aidouri, Alessa, 2010) Alhagi sparsifolia is rich in biologically active phytochemicals such as polysaccharides, phenolics, ...
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Braz. J. Pharm. Sci. vol.53 número1
... the main organ in body, which metabolizes chemicals and drug. It has been well known that enzyme AST and ALT are markers of hepatocyte damage and the high level of AST and ALT is an important marker for ...
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Glycyrrhizin attenuates endotoxin- induced acute liver injury after partial hepatectomy in rats
... induces liver dysfunc- tion, or even multiple organ failure and ...acute liver injury after partial hepatecto- ...potent drug protecting the liver against endotoxin-induced ...
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Exogenous normal lymph reduces liver injury induced by lipopolysaccharides in rats
... All rats were anesthetized with 50 mg/kg 1% pento- barbital sodium and were randomly assigned to the sham, LPS, and LPS+ +ENL groups (n = 20). The left jugular vein and the right carotid artery were aseptically separated ...
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Free radical scavenging activity of Berberine in acetaminophen induced liver injury
... OTC drug in ...in liver disease, obesity [13- 15], dyslipidemia, and cardiac disorders, and ...acetaminophen-induced liver injury in comparison to N-acetyl ...
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Hepatoprotective Effect of Wheat-Based Solid-State Fermented Antrodia cinnamomea in Carbon Tetrachloride-Induced Liver Injury in Rat.
... to liver complaints ...of drug doses from humans to rats, we converted the human dose to an animal dose based on the body surface area, and not by a simple conversion based on body weight, because body ...
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Bark Extract of Bathysa cuspidata in the Treatment of Liver Injury Induced by Carbon Tetrachloride in Rats
... of liver toxicity (Brattin et ...on liver disorders (Khan and Ahmed 2009; Sreelatha et ...new drug and applications, including liver diseases induced by the toxic agents (Shen et ...and ...
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Uridine prevents fenofibrate-induced fatty liver.
... also induced hyper-acetylation to proteins with molecular weights of approximately 80 kD, which was detectable with 1-D Western blots ...fenofibrate induced hyper-acetylation of proteins that have ...
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Drug-induced regulation of target expression.
... way, drug-induced differential expression of drug target mRNA was examined in three cell lines using the Connectivity ...heterogeneous drug treatments. In 1290 drug-target relations, ...
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PTTG1 attenuates drug-induced cellular senescence.
... Cells (0.1 ml Matrigel containing 1610 6 cells) were injected subcutaneously into the lumbar area at left side to generate tumors. Tumors were allowed to grow when the first tumor reaching ,100 mm 3 , at which time mice ...
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Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death
... the liver, promotes the degradation of the iron exporter ferroportin expressed on the surface of iron-releasing cells, thus reducing intestinal iron absorption and its mobilization from hepatic stores, and ...
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Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice.
... alcohol-induced liver injury using primary cultured hepatocytes treated with ...increase liver injury and inflammation which is not observed in other alcohol animal ...ethanol- ...
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Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.
... Primary liver cancer—a tumor that starts when a liver cell acquires genetic changes that allow it to grow uncontrollably—is the second-leading cause of cancer- related deaths worldwide, killing more than ...
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Doxycyclin induced esophageal injury: A Case series
... Some drugs have been known to damage to esophagus for a long time. Half of the cases reported are of tetracy- cline and its derivatives. The damage caused by these drugs is depends on the drug itself and the ...
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Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice.
... CLA administration. Likewise, scoring of macrophage influx, parenchymal collapse, consolida- tion, and alveolar epithelial cell changes were significantly higher in RT mice (vs CTL mice) and lower in RT + CLA mice (vs RT ...
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Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.
... nerve injury is associated with denervation, atrophy, and in turn muscle weakness ...nerve injury can enhance mus- cle reinnervation, as well as grip strength and hindlimb motor function ...
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