Functional genomics
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.
... understood. Functional genomics based on RNA-mediated interference (RNAi) provides the opportunity to derive unbiased comprehensive collections of pharmaceutically tractable single gene targets supporting ...
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Functional genomics complements quantitative genetics in identifying disease-gene associations.
... into functional networks of ...diverse functional genomics data through networks has been intensively studied, with the purpose of elucidating the functional roles of genes [8–11], predicting ...
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New developments of RNAi in Paracoccidioides brasiliensis: prospects for high-throughput, genome-wide, functional genomics.
... daughter cells with one nucleus. Interestingly, in the case of the multinucleate dimorphic fungus B. dermatitidis, the first round of selection after co-cultivation results in a transformant population characterized by ...
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Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques.
... Oligonucleotide microarray analysis. Infected macaque lung samples were co-hybridized with a reference mock-infected macaque lung sample on macaque oligonucleotide arrays containing 131 viral probes, corresponding to 26 ...
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Functional Genomics Unique to Week 20 Post Wounding in the Deep Cone/Fat Dome of the Duroc/Yorkshire Porcine Model of Fibroproliferative Scarring
... Conclusions/Significance: 1) The scars are still thick at forty-six weeks post wounding further validating the model. 2) The differential transcriptome provides new insights into the fibroproliferative process as several ...
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Metagenomics and functional genomics of bacterial symbionts of Spongia (Porifera, Dictyoceratida) specimens from the Algarvian shore (South Portugal)
... higher in coastal sediments (Schmidt et al., 1998) and in Dictyoceratida sponges (Hardoim et al., 2012) than in seawater, may be a key factor promoting genetic exchange and adaptive features likely to prevail in the ...
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Application of functional genomics in the production of viral biopharmaceuticals: vaccines and vectors for gene therapy
... However, RV manufacture faces several challenges, particularly the low yields of current producer cell lines and the high content of non-infective particles (an av[r] ...
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A viral-human interactome based on structural motif-domain interactions captures the human infectome.
... different functional genomics studies is small [6], a common characteristic of the results produced by high-throughput technologies during the post- genomic era ...
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Progress with schistosome transgenesis
... that schistosomes possess the various components of the RNAi machinery (Krautz-Peterson & Skelly 2008a), (Verjovski-Almeida et al. 2003) and that RNAi is active in schistosomes. Previous studies in RNAi in ...
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Human social genomics.
... social genomics has begun to analyze how everyday life circumstances influence human gene ...the functional genomics of optimal health and ...network genomics analyses examining how ...
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Candidate genes detected in transcriptome studies are strongly dependent on genetic background.
... In Drosophila an increasing number of whole genome expression studies relating gene expression to genetic differences in stress resistance traits and longevity have now been carried out [1,2–7]. These studies are focused ...
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Generation and analysis of a large-scale expressed sequence Tag database from a full-length enriched cDNA library of developing leaves of Gossypium hirsutum L.
... Gossypium hirsutum is one of the most economically-important species in its genus. Unfortunately, to date, its genome has not been completely sequenced. Recent efforts have demonstrated that EST sequencing is an ...
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Hist. cienc. saudeManguinhos vol.19 número1
... In a study carried out at the Laboratório de Genômica Funcional e Bioinformática (Laboratory for Functional Genomics and Bioinformatics) of the Instituto Oswaldo Cruz (Oswald Cruz Instit[r] ...
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Genomics and biology come together to fight HIV.
... the genomics revolution continues to identify new determinants of responses to HIV and other infectious agents [6], novel experimental paradigms like those being pioneered by Telenti and Elledge and colleagues ...
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Functional interactome of Aquaporin 1 sub-family reveals new physiological functions in Arabidopsis Thaliana
... the functional interactome of PIP1B, there are two interesting interactors; WOL (histidine kinase 4) is cytokinin-binding receptor that transducers cytokinin signals across the plasma membrane and Rps2 which is ...
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Genomics and X-ray microanalysis indicate that Ca
... fastidiosa , and X-ray microanalysis demonstrated the presence of elemental sulfur both in cells grown in vitro and in cells found inside plant vessels, indicating that the sulfur sign[r] ...
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Population Genomics of the Euryhaline Teleost Poecilia latipinna.
... To determine the extent of genetic variation and how it is partitioned among populations, we provide data on the genetic diversity in the teleost fish Sailfin molly ( Poecilia latipinna [r] ...
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Comparative Genomics Suggests Primary Homothallism of Pneumocystis Species
... nizes humans and causes severe pneumonia in immunosuppressed individuals. In the absence of in vitro cultures, the life cycle of these fungi remains poorly known. Sexual reproduction probably occurs, but the system of ...
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Comparative genomics of an endophytic Pseudomonas putida isolated from
... We isolated a number of endophytic Pseudomonas strains from dead tissues of bark, leaves and inflorescence of mango (Mangifera indica) trees grown in agricultural farms in mango growing districts in Sindh province of Pa- ...
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Texto contexto enferm. vol.22 número2 en v22n2a31
... ABSTRACT: This study aimed to relect on oncology nurses’ practice from the perspective of genetics and genomics, and their role as a member of the multiprofessional and interdisciplinary cancer genetics counseling ...
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