Gla protein
Matrix Gla Protein expression pattern in the early avian embryo
... (Matrix Gla Protein) is an extracellular matrix vitamin K dependent protein previ- ously identified as a physiological inhibitor of calcification and shown to be well conserved among vertebrates ...
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Matrix gla protein in turbot (Scophthalmus maximus): gene expression analysis and identification of sites of protein accumulation
... (Gla) protein (Mgp) is a vitamin K- dependent protein known for its capability of binding mineral ions through its gamma-carboxylated glutamic acid ...this protein could act as a local ...
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Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: Calcified cartilage and not bone as the primary site of MGP accumulation in fish
... Matrix Gla protein (MGP) belongs to the family of vitamin K– dependent, Gla-containing proteins, and in mammals, birds, and Xenopus, its mRNA was previously detected in extracts of bone, cartilage, ...
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Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene
... ABSTRACT The vitamin K-dependent matrix Gla protein (MGP) is synthesized in a wide variety of tissues such as lung, heart, kidney, cartilage, and bone. Expression of the MGP gene is regulated by various ...
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Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.
... Matrix Gla protein (MGP) is an extracellular polypeptide that inhibits arterial calcification [9]. Mutations in the MGP gene are associated with Keutel syndrome [10], a rare autosomal re- cessive disease ...
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Matrix gla protein in xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations
... Matrix Gla protein (MGP) belongs to the family of vitamin K– dependent, Gla-containing proteins and in higher vertebrates, is found in the extracellular matrix of mineralized tissues and soft ...
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Sturgeon osteocalcin shares structural features with matrix gla protein evolutionary relationship and functional implications
... OC protein in the mineral phase of skeletal tissues – To further determine which protein(s) related to sturgeon OC gene would accumulate in the mineral phase of sturgeon skeletal tissues, matrix proteins of ...
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Expression of matrix gla protein (MGP) in breast cancer: a molecular and cellular approach
... suppressor protein, which help repair damaged DNA, playing an essential role in cell ...the protein, DNA may not be repaired properly and additional genetic alteration could lead to ...
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Cloning of the Bone Gla Protein gene from the teleost fish Sparus aurata (gilthead seabream). Molecular organization, developmental appearance and evolutionary implications
... 'H, 113 Cd and 31 P NMR of osteocalcin (bovine gamma-carboxyglutamic acid containing protein). Proudfoot, D., Skepper. Calciílcation of human vascular cells in viíro is correlated vv[r] ...
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Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis
... Osteoarthritis prevention and treatment are still limited impelling the need to identify novel targets and biomarkers for prevention, therapeutics and prophylactic treatment [9]. An interesting candidate is vitamin K, ...
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Gla-Rich Protein Is a Novel Vitamin K-Dependent Protein Present in Serum That Accumulates at Sites of Pathological Calcifications
... matrix Gla protein is considered one of the most relevant physiological inhibitors of soft tissue calcification know to ...VKD protein , Gla-rich protein (GRP) , which contains the ...
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Interaction studies of Gla-rich protein with bone morphogenetic proteins
... Matrix Gla protein is an established inhibitor of soft tissue calcification and, although still not completely understood, it is known that its inhibitory mechanism is regulated by antagonizing BMPs through ...
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Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: implications for calcification-related chronic inflammatory diseases
... Gla-rich protein (GRP) is the newest member of the VKDP family recently shown to be involved in the crosstalk between inflammation and calcification of articular tissues in osteoar- thritis ...matrix ...
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Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates
... acid Gla in pro- thrombin (3) opened the way for subsequent identifications of other Gla containing proteins in blood, all involved in coagula- tion (factors VII, IX, and X, and proteins C, S, and Z) and ...
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Studies towards unveiling the association of Gla-rich protein with osteoarthritis
... Matrix Gla protein immunodetection in this study also supports the relevance of γ- carboxylation for pathology development, since osteoarthritic cartilage tissues showed significantly higher amounts of ...
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Wiki-pi: a web-server of annotated human protein-protein interactions to aid in discovery of protein function.
... the protein-protein interactions determined through high-throughput experiments and that it is an extracellular ...extracellular protein may be involved in regulating metabolic processes, catalytic ...
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Screening for protein-DNA interactions by automatable DNA-protein interaction ELISA.
... To further validate the DPI-ELISA screen, we conducted this method with DBPs from different protein families. We decided to use representatives of transcription factor families that are distinguished by their ...
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Interaction between plate make and protein in protein crystallisation screening.
... a protein with its optimal plate make. In protein crystallisation condition screening using vapour diffusion, the type of plate used could potentially contribute to three effects on crystallisation success: ...
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Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 –
... Mipu1 protein has a very high level of expression in the heart and liver of normal rats and is mainly located in the nuclei of H9c2 myogenic cells, but it has a very low level of expression in liver, testis, ...
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Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions.
... In this study, we describe polymorphism in the P. falciparum gene pfcsp in two natural parasite populations and map predicted amino acid substitutions onto the recently elucidated crystal structure of the C terminal end ...
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