Hepatitis C/drug therapy
Experience of a Portuguese Center: Effectiveness of Direct-Acting Antiviral Therapy for Hepatitis C
... ated by CHLO P&T. All patients were counseled by hos- pital pharmacists prior to receiving their medication. Data related to adverse drug reactions were collected through standard-of-care operating procedures ...
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Zebrafish as a potential model organism for drug test against hepatitis C virus.
... Current therapy for HCV infection is the combination of Pegylated-interferon (PEG-IFN) with ribavirin [1,2]. This regimen has only suboptimal clinical efficacy and is with side-effects [3,4]. It is widely agreed ...
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Ribavirin-induced anemia in hepatitis C virus patients undergoing combination therapy.
... considered (Fig. 5), we estimate that steady state plasma ribavirin concentrations above 13 m M would render ribavirin therapy intolerable. Determining dosage levels corresponding to this steady state plasma ...
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A hepatitis C virus infection model with time-varying drug effectiveness: solution and analysis.
... of therapy for viral diseases, such as hepatitis C virus (HCV) or human immunodeficiency virus, to patient data has yielded significant insights into the underlying viral ...once therapy is ...
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Ocular changes due to systemic alpha-interferon therapy for hepatitis C
... (IFN) therapy in patients with hepatitis ...alpha-interferon therapy for hepatitis ...before therapy and 1, 3, 6 and 12 months after starting the ...to hepatitis, and one patient ...
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Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
... viral hepatitis, as well as in the treatment of the extrahepatic manifestations related to HCV ...active hepatitis C and MPGN with IFN- α, and observed a decrease in proteinuria as well as in serum ...
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Splenectomy prior to antiviral therapy in patients with hepatitis C virus related decompensated cirrhosis
... combination therapy regimen was assigned according to the HCV ...for drug-related complications, such as cytope- nia, to facilitate timely dose reductions or discontinuation of antiviral ...
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Hepatitis C in hemodialysis: the contribution of injection drug use
... Using a structured questionnaire, previously trained in- terviewers, blind to laboratory results, the following infor- mation was collected from the patients: age, sex, duration of HD, previous blood and/or blood product ...
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Efficacy of combined antiviral therapy with pegylated interferon α-2a and ribavirin for chronic hepatitis C infection in intravenous drug users
... p>0.05). A large number of the patients in the group of IDUs had a problem with the abstinence of the drug abuse. In this group, there was the influence of alcohol (30%) and other substances with potential ...
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Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
... both drug-induced thyroiditis and autoimmune thyroid disease. However, the mechanisms of induced thyroid dis- ease are complex and not completely understood. The clear association between autoimmune thyroid ...
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Hand-foot syndrome due to hepatitis C therapy
... interferon are well tolerated and have fewer side ef- fects. Occasionally, it is difficult to assign a symptom to a drug or another. Some adverse effects were re- lated with to sofosbuvir, such as fatigue, ...
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NEW THERAPIES FOR HEPATITIS C
... Combination therapy with oral antiviral drugs will require company portfolios to contain more than one such ...preclinical drug-drug interaction studies will have to be performed before clinical ...
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ADHERENCE, ADVERSE DRUG REACTION AND EFFECTIVENESS OF THE HEPATITIS C CHRONIC TREATMENT
... the therapy and discuss the im- portance of medication ...ble drug-drug interaction (DDI) with prescription and over-the-counter medicines (OTC), laboratory moni- toring, and likelihood of ...
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Arq. Gastroenterol. vol.47 número3
... injecting drug users might not differ from the general population in terms of sustained virological response when adherent to therapy for chronic hepatitis ...for therapy in this group of ...
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Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil
... cocaine drug users, this difference may be attribut- able to the sharing of contaminated implements such as straws that are commonly used to inhale this drug (Mc- Mahon et ...
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DIFFERENT MODELS OF HEPATOTOXICITY AND RELATED LIVER DISEASES: A REVIEW
... Jaundice (also known as icterus; attributive adjective: icteric) is a yellowish pigmentation of the skin, the conjunctival membranes over the sclerae (whites of the eyes), and other mucous membranes caused by ...
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Chronic hepatitis C: hepatic iron content does not correlate with response to antiviral therapy
... between hepatitis C virus infection, iron homeostasis and the response to antiviral treatment remains ...antiviral therapy in patients with chronic hepatitis ...iron therapy were ...
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Universidade Federal de Uberlândia Faculdade de Medicina Sandra Regina Xavier Santos
... FRIED, M.W.; SHIFFMAN, M.L.; REDDY, K.R. et al. Peginterferon alpha-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med., USA, v. 347, n. 13, p. 975-982, Sep. 2002. GELU-SIMEON, M.; ...
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Hepatitis C and hemodialysis: a review
... on Hepatitis C viremia standards in patients that have undergone hemodialysis, in seven dialysis centers in Austria and one in Northern Italy, observed fluctuation in the degree of viremia in one-third of ...
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Chronic Hepatitis C: Pathological Anatomy
... cases, hepatitis C histologically manifests in the same manner before the transplant: with portal and parenchymal inflammation, aggression of the interface with piecemeal necrosis, and fibrosis at portal ...
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