Iron overload
Analysis of HFE gene mutations and HLA-A alleles in Brazilian patients with iron overload
... Genotyping patients for C282Y and H63D mutations is useful for confirming the diagnosis of HH and for family studies. Most European studies have reported that 60-90% of typical hemochromatosis patients are homozygous for ...
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Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI
... and iron quantification in clinical ...hepatic overload might explain the absence of significant differences in PDFF measure- ments between histologic steatosis grade 1 and 2, and it could also have ...
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Iron overload alters glucose homeostasis, causes liver steatosis, and increases serum triacylglycerols in rats
... of iron overload with a hyperlipidemic diet on the histologic feature of hepatic tissue, the lipid and glycemic serum profiles, and the markers of oxidative damage and stress in a rat ...with iron) ...
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ROLE OF FERRITIN IN THE RICE TOLERANCE TO IRON OVERLOAD
... control, iron overload (+ Fe) and iron deficiency (- Fe) conditions (25 μg of total protein per ...or iron overload treatments for 9 ...
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Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway
... that iron overload led to a dose-dependent decrease of MMP in ...that iron overload caused the upregulation of Bax and cleaved caspase-3, as well as the downregulation of ...in iron ...
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Protective effects of deferasirox and N-acetyl-L- cysteine on iron overload-injured bone marrow
... excessive iron negatively affects the hematopoietic system by damaging hematopoietic cells and hematopoietic micro- environment ...that iron chelation therapy (ICT) can improve hematopoiesis and exert a ...
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Baroreflex function in conscious rats submitted to iron overload
... Chronic iron overload produces heart dysfunction in a dose-dependent manner (8), probably resulting from the time lag neces- sary to deposit iron in ...heart, iron, initially deposited in the ...
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Baroreflex function in conscious rats submitted to iron overload
... that iron accumulated in tissue, rather than in serum, may compromise cardiovascular ...serum iron overload group (SIO, N = 12), 20 mg elemental iron was injected ip daily for 7 ...tissue ...
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Two kinds of ferritin protect ixodid ticks from iron overload and consequent oxidative stress.
... [2]. Iron was particularly reported to induce lipid peroxidation [32,33] and oxidation of several amino acid residues in proteins ...excess iron is crucial to preventing oxidative ...of iron, either ...
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THE EFFECT OF IRON DEFICIENCY AND IRON OVERLOAD ON THE EVOLUTION OF CHAGAS DISEASE PRODUCED BY THREE STRAINS OF TRYPANOSOMA
... However, if the concentration of iron in serum was lower than normal, the iron stocks (liver and spleen) were not affected by infection, (compare the concentrati[r] ...
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Rev. Bras. Hematol. Hemoter. vol.35 número6
... of iron overload of different organs besides the heart, such as the liver, pituitary gland and pancreas as well as gain information on cardiac volumes and ...myocardial iron concentration (MIC) (46) ...
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CHARACTERIZATION OF THE CLINICAL, HISTOLOGICAL AND GENETIC PROFILE OF ARTICULAR DAMAGE IN HEREDITARY HEMOCHROMATOSIS
... of iron overload by liver biopsy, so we used ferritin concentra- tion as a surrogate marker, with severity of iron overload defined by serum ferritin concentra- tion !1000 μg/L at ...
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Einstein (São Paulo) vol.11 número4
... to iron overload, including xerocytosis, since these patients often present with symptoms of heart failure and diabetes, secondary to hemochromatosis, even without an elevated number of transfusions, or ...
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Impact of iron oload on interleukin10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia
... with iron overload (Iron overload Group; n = 15) and the other, patients with sickle cell anemia but without iron overload (Non-iron overload Group; n = ...
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Rev. Bras. Hematol. Hemoter. vol.32 número6
... When SF is consistently high, it is associated with clinical signs and symptoms related to iron overload. Thus, clinical history and physical examination are essential to assess the presence and intensity ...
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Avaliação bioquímica e hostológica de fígado de ratas wistar diabéticas e tratadas com tamoxifeno
... The purpose of this multidisciplinary study was to evaluate the correlation between plasma hepatic enzyme levels and the presence of iron overload in the hepatic tissue of female Wista[r] ...
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Ferro e Doena Heptica Alcolica
... Iron’s complex metabolism in light of recent discoveries concern- ing its absorption and distribution is closely related to the phisi- opatology of alcoholic liver disease. The authors perform a theo- retical review ...
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Rev. Bras. Hematol. Hemoter. vol.35 número1
... Methods : A cross-sectional study was performed of 30 patients with molecular diagnosis of sickle cell anemia. Patients were stratiied into two groups, according to the presence of iron overload: ...
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HFE gene mutation and oxidative damage biomarkers in patients with syndromes and its relation to transfusional iron oload : an observational crosssectional study
... consequent iron overload (IOL), considered to be a negative inde- pendent prognostic factor associated with a higher risk of leukaemic transformation and shorter ...of iron due to multiple ...
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