Lipoic acid
Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis
... Figure 4. Organ-bath vasoreactivity studies in rabbit aortic rings. Contractions to 0.1 mM noradrenaline (A), 0.12 M KCl (B) or 0.1 mM L- NAME (C). Relaxation to acetylcholine (Ach) (D) or sodium nitroprusside (NPS) (E) ...
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Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid.
... a-lipoic acid (LA), an obligate co-factor for intermediary metabolism including energy ...ascorbic acid, butylated hydroxyanisole and edaravone, failed to exhibit any beneficial ...tricarboxylic ...
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Evidence for protective effect of lipoic acid and on oxidative stress in a model depression in mice
... Antidepressants are among the therapeutic agents most commonly prescribed for the treatment of MDD. Desvenlafaxine succinate (DVS), an active metabolite of venlafaxine is a dual serotonin and noradrena- line reuptake ...
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Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences
... Abstract—Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world’s popula- tion. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an ...
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Growth performance, intestinal morphology, and meat quality in relation to alpha-lipoic acid associated with vitamin C and E in broiler chickens under tropical conditions
... Alpha-lipoic acid is also capable of recycling ...dihydrolipoic acid in the presence of vit. E (Scholich et al., 1989). Alpha-lipoic acid inclusion in vivo increases the level of ...
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Behavioral and neurochemical effects of alpha lipoic acid associated with omega3 in tardive dyskinesia induced by chronic haloperidol in rats
... Abstract: Tardive dyskinesia (TD) is characterized by involuntary movements of the lower portion of the face being related to typical antipsychotic therapy. TD is associated with the oxidative imbalance in the basal ...
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Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.
... Lipoic acid (1,2-dithiolane-3-pentanoic acid) was reported to increase glucose uptake in L6 muscle cells and 3T3-L1 adipocytes [24,25], induce the redistribution of GLUT4 to the plasma membrane in ...
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Two Novel Donepezil-Lipoic Acid Hybrids: Synthesis, Anticholinesterase and Antioxidant Activities and Theoretical Studies
... Alzheimer disease (AD) is a complex disease related to multiple pathogenic mechanisms. A strategy to develop effective drugs is based on the so-called multi-target directed ligands (MTDL) by using hybrid compounds. So, ...
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Epigallocatechin-3-gallate combined with alpha lipoic acid attenuates high glucose-induced receptor for advanced glycation end products (RAGE) expression in human embryonic kidney cells
... The anti-oxidant effects of epigallocatechin gallate (EGCG) and alpha lipoic acid (ALA) have been demonstrated in previous studies. The kidney protection effects of EGCG and ALA in patients with kidney ...
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Toxicological Effects of Alpha Lipoic Acid in Streptozotocin-Induced Diabetes in Wistar Rats
... The generation of free radicals, which results in toxicity of tissues of diabetic-induced animals cannot be over emphasized. However, Alpha lipoic acid (ALA) plays an important role in scavenging these free ...
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Stabilization of lipoic acid by encapsulation in polymeric nanocapsules designed for cutaneous administration.
... OF LIPOIC ACID BY ENCAPSULATION IN POLYMERIC NANOCAPSULES DESIGNED FOR CUTANEOUS ...containing lipoic acid prepared by interfacial deposition of ...showed acid pH and encapsulation ...
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Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival.
... fatty acid biosynthesis operating in the organelle is the major source for the LA precursor octanoyl- ACP ...fatty acid biosynthesis in mammalian cells is octanoyl-ACP, which is efficiently ligated to the ...
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Behavioral and neurochemical effects of alphalipoic acid in the model of Parkinson’s disease induced by unilateral stereotaxic Injection of 6Ohda in rat
... 𝛼-lipoic acid alone or in combination with L-DOPA on lipid peroxidation in the prefrontal cortex (a), hippocampus (b) and striatum (c) of rats pre-treated with ...
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Int. Arch. . vol.19 número1
... Final Comments Topical clonazepam showed good short-term results for the relief of pain, although this was not presented as a definitive cure. Similarly, α-lipoic acid showed good results, but there are few ...
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Arq. NeuroPsiquiatr. vol.61 número3B
... a- lipoic acid, the animals of group 2 with ...α-lipoic acid. The animals of group 3 received 60.6 mM α-lipoic acid ...α-lipoic acid intracarotid infusion and the ...
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Influência do ácido α-lipóico na adaptação antioxidante ao exercício físico em ratas wistar hígidas e ovariectomizadas
... The objective of this study was to investigate the effects of moderate daily swimming and lipoic acid supplementation on estrous cycle duration and pro- oxident an[r] ...
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Arq. NeuroPsiquiatr. vol.68 número4
... search project was approved by the Ethics Committee of the Federal University of Piaui, Brazil (Protocol Number 038/09). he following substances were used: pilocarpine hydrochloride and alpha-lipoic acid ...
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Adição de agentes antioxidantes na solução de vitrificação do tecido ovariano ovino: Uma perspectiva para refinar e aperfeiçoar o protocolo
... alpha lipoic acid in different concentrations to reduce generation of reactive oxygen species (ROS), aiming to obtain less damage on follicular morphology and development, stromal cell density, alterations ...
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Arq. NeuroPsiquiatr. vol.69 número2B
... the lipoic acid (LA) effects in glutamate and taurine contents in rat hippocampus after pilocarpine-induced ...amino acid concentrations were measured using high-performance liquid chromatograph ...
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Metabolic profiles and free radical scavenging activity of Cordyceps bassiana fruiting bodies according to developmental stage.
... aspartic acid, mannitol, glycerophosphoric acid, and ...aspartic acid, valine, isoleucine, serine, threonine, lysine, glutamine, histidine, and ...uric acid, adenosine, guanosine, and glycine; ...
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