Negative regulator
SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens.
... Recent studies suggest that the innate hypo-responsiveness of IEC may in part reflect the actions of Single Ig IL-1 related receptor (SIGIRR) (also called TIR8), a negative regulator of IL- 1R and TLR ...
20
An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion.
... identified negative regulator phenotype, we would expect that the over-expression of SFRS3 would either produce no change in the levels of IL-1b secretion or, more convincingly, decrease cytokine ...7 ...
10
CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA1.
... find negative regulators in TCR-mediated NF-kB activation, using somatic mutagenesis and complementation cloning strategies ...which negative regulators for NF-kB activation must be ...NF-kB negative ...
11
A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans.
... transcriptional regulator-defective mutants were ...a negative regulator of ...novel negative regulator of NSR and bring new insights into the transcriptional regulatory network ...
11
Drosophila protein kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis
... Actin –myosin cytoskeleton contractility is regulated by the equilibrium between distinct kinases (e.g., MLCK, ROK, ZIP) and phosphatases (in most cases, Myosin phosphatase, PP1) activities (Grassie et al., 2011; ...
15
HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.
... spectrometry and yeast 2-hybrid analyses several proteins that interact with the N-terminal region of Glis3. These include the WW-domain-containing HECT E3 ubiquitin ligases, Itch, Smurf2, and Nedd4. The interaction ...
22
Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo
... a negative regulator of CD8 + T-lymphocyte activation and that the lack of HFE may render CD8 + T lymphocytes less tolerant to constant stimuli and more suscep- tible to autoimmune phenomena ...
22
KLF2--a negative regulator of pre-B cell clonal expansion and B cell activation.
... Next, we investigated the role of KLF2 in mature B cells. Others and we found the expression of KLF2 in mature, resting splenic B cells. Upon stimulation mimicking T-independent activation (LPS) or T-dependent activation ...
8
NDT80 transcription factor as a negative regulator for Candida parapsilosis adhesion and biofilm formation
... mechanisms that the ones described for C. albicans. A resistant strain obtained after exposure to posaconazole has shown an upregulation of two transcriptional factors, Upc2 and Ndt80. The aim of this work was to assess ...
46
The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity.
... on average 20% of the number achieved by YAP overexpression (Figure 4C–D). However, in the presence of ectopic YAP MCF- 10A cells with PTPN14 knockdown formed approximately 3 times more colonies than cells with YAP ...
9
Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.
... Positive immunohistochemical staining for Tensin3 in RCC tissue sections was found in the cytoplasm and at varying intensities. There was no Tensin3 expression in the fibrovascular stroma or endothelial cells of tumour ...
13
Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene.
... Interferon treatment of certain cell types inhibits cell prolifer- ation through inhibition of the progression of cells through the S- phase of the cell cycle [55] and increased levels o[r] ...
9
Salinomycin activates AMP-activated protein kinase-dependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis.
... salinomycin needs further characterization. Interestingly, we found that ROS was not only required for AMPK-autophagy activation, it was also important for salinomycin-induced apoptosis and cell death .Thus we concluded ...
11
The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.
... We show that stam and hrs modulate RTK signalling activities either positively or negatively according to the tissue and the developmental stage. hrs and stam are essential for efficient activation of the FGFR signalling ...
10
Interleukin-19 acts as a negative autocrine regulator of activated microglia.
... Activated microglia can exert either neurotoxic or neuroprotective effects, and they play piv- otal roles in the pathogenesis and progression of various neurological diseases. In this study, we used cDNA microarrays to ...
12
TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING.
... Several negative regulators of the STING-meditated DNA signaling pathway have been ...another negative regulator of STING-induced innate immune response ...
18
Antioxidants: Positive or Negative Actors?
... Glutathione formation through Nrf2 activation can lead to reactive oxygen reduction and, thus, possibly an NF-κB decrease but also may react with chemotherapy and radiation generated sp[r] ...
11
Retinoic acid: a key regulator of vertebrate embryonic development
... The mechanism by which RA promotes the HTT is still unclear. Considering the Wnt3 and Wnt3a expression patterns and their differential roles in head and trunk formation (described in Chapter I), it is possible that RA ...
71
Novel regulator MphX represses activation of phenol hydroxylase genes caused by a XylR/DmpR-type regulator MphR in Acinetobacter calcoaceticus.
... regulator families. BLAST (http://blast.ddbj.nig.ac.jp/top-e.html) and CDART (http://www.ncbi.nlm.nih.gov/Structure/lexington/ lexington.cgi) searches suggest that MphX belongs to the COG4313 family in the COG ...
11
mTOR pathway is a novel regulator of male fertility
... a negative impact of sirolimus on sex hormone levels was reported (Kaczmarek et ...The negative effect of sirolimus on male sex hormone levels was further confirmed in other studies with renal-transplant ...
181