[PDF] Top 20 Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data
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Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data
... oligoprogression), in which the central nervous system (CNS) or other extra-CNS sites may be the main locations of progression ...(64). In sites such as the brain and bone, local therapy options ... See full document
11
Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines.
... tumor growth in an Hh ligand-independent or -dependent manner[43]. In most basal cell carcinomas (BCCs) and medulloblastomas, loss-of-function mutations in PTCH and ... See full document
16
Baseline and Trend of Lymphocyte-to-Monocyte Ratio as Prognostic Factors in Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer Patients Treated with First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.
... role in tumor eradication[11] and macrophages are associated with tumor progression[12, 13], we presumed that patients with higher lymphocyte- to-monocyte ratio (LMR) might have better prognosis in ... See full document
13
Rev. Assoc. Med. Bras. vol.62 número1
... of clinical oncology, we have advanced to- ward more comprehensive detailing of histological types and the genetic proile of ...of lung cancer as non-small cell has been insuf- icient to plan ... See full document
3
Clinics vol.67 número11
... al. in a recent issue of your esteemed journal with great interest ...new data have emerged that reveal the emerging role of epidermal growth factor (EGF) and its receptor ... See full document
1
Androgen receptor expression in triple-negative breast cancer
... of epidermal growth factor (EGF), through tyrosine-kinase ...described in different tumors, especially in the central nervous system, lung and stomach ...described ... See full document
80
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival
... treatment and histological diagnosis of cholangiocarcinoma. We collected data regarding gender, age, previous history, history of smoking or alcoholism, presence of gallstones, family history for neoplasia, ... See full document
9
Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification.
... with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) eventually develop acquired resistance to EGFR tyrosine kinase inhibitors ...resistance ... See full document
13
Braz. Dent. J. vol.23 número4
... protein, epidermal growth factor receptor (EGFR) and Notch-1 in the epithelial lining of radicular cysts (RC), dentigerous cysts (DC) and keratocystic odontogenic tumors ... See full document
7
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
... basic, preclinical, and clinical findings indicated that epidermal growth factor re- ceptor (EGFR)-mediated aberrant signaling transduction is crucial in HNSCC ... See full document
17
Study on invadopodia formation for lung carcinoma invasion with a microfluidic 3D culture device.
... invasive cancer cells, are a key determinant in the malignant invasive progression of tumors and represent an important target for cancer ...therapies. In this work, we presented a ... See full document
7
Int. braz j urol. vol.36 número3
... made in the integration of new biologically- targeted agents in the treatment of ...breast cancer patients have over-expression or ampliication of HER2/neu ...used in breast cancer ... See full document
10
Clinics vol.67 número5
... Epidermal growth factor receptor (EGFR) is critically involved in NSCLC pathogenesis and has recently emerged as an important target for molecular ...gefitinib and ... See full document
6
MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.
... Epidermal growth factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family controls key cellular programs, including survival, ... See full document
22
Recent Updates on the Management of Medullary Thyroid Carcinoma
... fit and toxicity [5,16]. Activating germline mutations of the RET proto-oncogene, a tyrosine kinase receptor, are found in almost all patients with MEN2A and ...RET mutations ... See full document
8
A novel classification of lung cancer into molecular subtypes.
... aberrations in PI3K, a lipid kinase that regulates growth in the AKT/PI3K ...classes and several subclasses based on primary structure, regulation, and in vitro lipid substrate ... See full document
11
Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR.
... complex, and reader ...quantitative, and independent of reader ...survival. In addition, our optimal cutpoint analysis suggests that there is a clear threshold ...amplification and survival; ... See full document
8
Einstein (São Paulo) vol.13 número2
... demographic data and clinical outcomes of non-small-cell lung cancer patients exposed to erlotinib in any line of ...small-cell lung cancer patients from a ... See full document
6
J. Bras. Patol. Med. Lab. vol.51 número5
... heterogeneity, and accounts for about 70%-80% of malignant breast ...differentiation, and status of axillary lymph ...(CNSm), and generally the response to systemic treatment/chemotherapy is ... See full document
6
Arq Bras Endocrinol Metab vol.51 número4
... maturation and stability of a variety of proteins, many of which are crucial in oncogenesis, including epidermal growth factor receptor (EGF-R), Her-2, AKT, BRAF, CRAF, p53, ... See full document
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