[PDF] Top 20 Fexinidazole: A Potential New Drug Candidate for Chagas Disease

... the disease to confirm the therapeutic efficacy of fexinidazole as observed in the first and second ...and fexinidazole was administered on day 120 post-infection for 20 consecutive ...after ... See full document

... sulfone fexinidazole metabolites following oral administra- tion in a murine model of Chagas ...doses. Fexinidazole metabolites were effective in reducing the numbers of circulating para- sites and ... See full document

... for new drug discovery efforts aimed at treating kinetoplastid ...of drug targets for these diseases. For Chagas disease, only sterol 14α-demethylase (CYP51) and cruzain have been ... See full document

... or Chagas’ ...this disease in South and Central America ...of new inhibitors that function as novel antiparasitic drugs for the treatment of Chagas’ disease ... See full document

... ideal drug, with its efficacy and tolerance being inversely related to the age of the patient ...other drug clinically available was Nifurti- mox, but it has been discontinued from Bayer’s production ... See full document

... Some new nitroheterocyclic compounds have been proposed as candidate drugs for Chagas’ disease chemotherapy, 3-6 some of which have a trypanocidal action due to their ability to be reduced by ... See full document

... of Chagas disease is frequently based on tests such as enzyme-linked immunoassays (EIAs), indirect immunofluorescence assays, and indirect haemagglutination assays ...and Drug Administration for use ... See full document

... the disease (Rocha et ...of new trypanocidal com- pounds to replace these current ...to potential preclinical experimental hosts shall be con- ...a drug screening ... See full document

... the disease (Rocha et ...of new trypanocidal com- pounds to replace these current ...to potential preclinical experimental hosts shall be con- ...a drug screening ... See full document

... These drugs have been used for more than 50 years. Treatment with Bz during the acute phase of the disease is able to cure approximately 60% of the patients. However, the cure rates do not exceed 20% when Bz is ... See full document

... of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors ...compounds, new triazole derivatives that inhibit ... See full document

... Chagas disease is caused by the parasite Trypanosoma cruzi and affects approximately eight million individuals in the developing world; it is also classified as a neglected tropical disease by the ... See full document

... vector-borne disease control programme [Enfermedades Transmitidas por Vectores (ETV)] of each department investigated houses with the risk ...about Chagas disease and the physical appearance of the ... See full document

... In Mexico, the infection by T. cruzi is mainly silent. Thus, like in most countries of Latin America, Chagas dis- ease has become an urban disease, due to the migration of people from endemic areas to the ... See full document

... in drug- eluting balloon technology. One is the drug, the other is the balloon catheter, and the last is the excipient that binds the drug to the balloon catheter surface and releases it to the ... See full document

... 49. Moraes DNM, Nascimento BR, Beaton AZ, Soliman EZ, Lima- Costa MF, dos Reis RCP, et al. Value of the electrocardiographic (P Wave, T Wave, QRS) axis as a predictor of mortality in 14 years in a population with a high ... See full document

... IL-8 is involved in the monocyte and neutrophil recruitment and activation process for sites of acute inflammatory response. It presents certain longevity in these sites, being produced at the beginning of inflammatory ... See full document

... of Chagas' disease in the Americas, based on available information and such other information as may be obtained from particular studies that are undertaken subject to the availability of budgetary ... See full document

... The auto-immune theory is supported by the lack of correlation between parasitism and chronic myocarditis. However, the great age variation of the patients at the onset of clinical manifestations, the lack of ... See full document

... We studied 160 eyes in the Chagas group and 152 eyes in the control group. Participants were asked to abstain from caffeine or other stimulants for 12 hours prior to the examination. The study was performed in a ... See full document