[PDF] Top 20 Genotoxicity of Microcystin-LR in In Vitro and In Vivo Experimental Models
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Genotoxicity of Microcystin-LR in In Vitro and In Vivo Experimental Models
... formation of 8-oxo-dG, peaking at 6 h after treatment and then declining, suggesting a fast repair of the DNA lesions [ 36 ...assay) in rodent’s blood cells [ 10 , 69 ]. For example, in ... See full document
10
Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo
... injection of 0.5 mg/kg ketamine and 1 mg/kg xylazine, and lung injury was induced by a single intratracheal instillation of 6 mg/kg bleomycin (BLM) hydrochloride (Nippon Kayaku, Japan) ... See full document
8
Evaluation of neuroprotective and neurotoxic functions of different microglia phenotypes in Alzheimer’s disease onset and progression, using in vitro and in vivo models
... their in situ counterparts when compared to immortalized cells, although by growing in isolation lack the normal CNS microenvironment (Ni and Aschner, ...immortalized and are differentiated ... See full document
250
Evaluation of anticonvulsant actions of dibromophenyl enaminones using in vitro and in vivo seizure models.
... resulted in the removal of the strong inhibitory influence of GABA [48–50] on the CA1 neurons and the transformation of the single PS into multiple PS ...activity in these ... See full document
10
Tumor microenvironment models: ex vivo, in vitro and in silico approaches to address targeted therapies
... SFRH/BD/52208/2013 and PD/BD/114047/2015; iNOVA4Health (UIDB/04462/2020), a program financially supported by FCT/Ministry of Education and Science, Portugal, through national funds and ... See full document
270
In vitro and in vivo establishment and characterization of resistant and metastatic human osteosarcoma models
... one of the most common primary bone tumors in childhood and ...development of various preclinical models mimicking at best the complexity of the disease and its metastatic ... See full document
194
Biological effects of polyacrylic acid-coated and non-coated superparamagnetic iron oxide nanoparticles in in vitro and in vivo experimental models
... properties in their absorption, biodistribution, biotransformation, metabolism and ...rapidly and nonspecifically captured by phagocytic cells and accumulate in the RES such as lymph ... See full document
247
The cardiotoxicity of mitoxantrone: a mechanistic approach using in vitro and in vivo models.
... the in vivo MTX treatment (Manuscripts III and IV), rats received three cycles of ...10, and 20, reaching the cumulative dose of ...end of the third cycle. Clinical ... See full document
190
In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.
... presentation of evaporated milk in daily sessions using procedures similar to those previously ...trained in drug discrimination via injection of saline (VEH) or ...presented in a ... See full document
27
Antitumor Activity of Kielmeyera Coriacea Leaf Constituents in Experimental Melanoma, Tested in Vitro and in Vivo in Syngeneic Mice
... docosanol and 1-hexacosanol, and the ketones 2- heptadecanone and 2-nonadecanone were ...lengths of C20 to C36, 42 these compounds constitute leaf cuticular waxes that may differ widely among ... See full document
8
In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections.
... aim of the present investigation was to study the activity of monepantel, compared with the reference drugs, albendazole, levamisole, and pyrantel pamoate, in five parasite-rodent ... See full document
7
Strongyloides ratti: in vitro and in vivo activity of tribendimidine.
... Discovered in the mid-1980s [15], detailed laboratory investi- gations and subsequent clinical testing for safety and efficacy have led to tribendimidine being registered in China, in ... See full document
7
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies
... toxicity of these diamidine com- pounds towards mammalian cells (LC 50 > 96 ...tion of the smaller linear molecules (DB1627, DB1646 and DB1670), which were not effective, exerted a very high ... See full document
10
Molecular targets of botulinum toxin serotypes A and C: an experimental in-vitro and in-vivo study
... some of the limitations presented by these toxins is the engineering of ...One of the hypothesis to engineering these toxins is to enhance their activity, making more potent ...duration of ... See full document
95
In vitro and in vivo experimental models for drug screening and development for Chagas disease
... people in endemic areas of Latin America. Al- though the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still remain ... See full document
6
Unreveling pathways of cyto and genotoxicity of AgNP in lung cells: in vitro and in vivo approach
... role in the MPS, but the latter was not incorporated into the PBPK-model which could be an explanation of the lower modeled silver levels in ...release and storage rates of AgNP used ... See full document
209
In vitro and in vivo studies of pirarubicin-loaded SWNT for the
... part of the treatment for superficial bladder ...limited and its side effects are ...accumulation and low toxicity. In the present study, we performed in vivo and ... See full document
7
In Vitro and In Vivo Biocompatibility Of ReOss® in Powder and Putty Configurations
... complementary in vivo evaluation was performed, as recommended by ISO7405:2008, in order to better understand their biocompatibility by direct interactions with host tissues, and contribute to ... See full document
11
In vitro and in vivo experimental models for drug screening and development for Chagas disease
... 75%) and treated with the dose established in the In vivo I ...onset of parasitaemia. Parasitaemia will also be assessed at 20, 25 and 30 dpi and the viability of ... See full document
6
Comparison of the in vivo and in vitro genotoxicity of glyphosate
... high genotoxicity of glyphosate in human lym- phocytes, Tradescantia nuclei and fish erythrocytes in vitro may be indicative of direct DNA damage (Kirkland, 1998; ... See full document
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