[PDF] Top 20 HIV-1 infection on Follicular Helper T cells
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HIV-1 infection on Follicular Helper T cells
... of HIV infection, preventing millions of AIDS-related deaths and improving HIV- infected individual’s life ...persistent HIV reservoirs which remain the major obstacle to a functional cure and ... See full document
69
Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART.
... targeting cells expressing RGD-binding integrin receptors such as dendritic cells, macrophages and activated endothelial cells via its RGD-binding site, extracellular Tat enters them very efficiently ... See full document
29
Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.
... Cells were collected at the time points indicated in the Results section and washed twice in staining buffer [PBS with 2% BSA and 0.1% Sodium azide]. They were stained for surface markers as indicated in the ... See full document
8
Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection.
... sorting cells were centrifuged in ...added. Cells were then incubated at 56uC for 1 hour, and then at 90uC for 10 ...4B). Cells were sorted in the following manner: Single cells were ... See full document
13
γδ T cells are involved in acute HIV infection and associated with AIDS progression.
... cd T cells are distinct from ab T cells, and generally lack CD4 or CD8 antigen expression ...These cells represent approximately 3–4% of peripheral T cells in the blood, ... See full document
10
Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals.
... than 1 PFU/MDDC caused a high cell death rate of MDDC at 48 h post-infection, while ...post- infection appeared as the optimal dose for the upregulation of CD86 and other maturation markers of MDDC, ... See full document
17
HIV Infection in T-lymphocytes and Drug Induced CTL Response of a Time Delayed Model
... research on the area of HIV-1 infection invad- ing the human immune system started in early nineties of the last century ...immune cells, HIV-1 pathogenesis and probable ... See full document
6
Abortive T follicular helper development is associated with a defective humoral response in Leishmania infantum-infected macaques.
... B cells generally depend on cognate interactions with CD4 T cells to differentiate into antibody-producing plasma cells (PCs) ...the follicular pathway and form a germinal center ... See full document
17
HIV-1/HSV-2 Co-Infected Adults in Early HIV-1 Infection Have Elevated CD4+T Cell Counts
... started on antiretroviral drug therapy until CD4+ T cell counts have decreased to 350 CD4+ T cells/ml or below, or is otherwise clinically ...CD4+ T cells fell bellow 300 ... See full document
5
DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.
... SIGN on the kinetics of infection with IIIB and IIIBx ...experiments, HIV was adsorbed to cells by spinoculation at low temperature to promote synchronous infection ...inhibitor ... See full document
14
HIV traffics through a specialized, surface-accessible intracellular compartment during trans-infection of T cells by mature dendritic cells.
... the T cell co-stimulatory protein CD86 are expressed at high levels on the cell surface (Figure 2E); however, focusing on the interior of the cell revealed that these markers were also present in the ... See full document
14
Superior control of HIV-1 replication by CD8+ T cells targeting conserved epitopes: implications for HIV vaccine design.
... in HIV-1- infected individuals over consensus clade-B peptide sequences ...early infection target variable epitopes, it is not clear that any additional insight would have been gained using ... See full document
13
HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.
... of T-cell response, the present study shows that treatment of MoDCs with Tat leads to an alteration of their capacity to stimulate T cell ...of T cell ...autologous HIV-1 infected ... See full document
12
On modeling HIV and T cells in vivo: assessing causal estimators in vaccine trials.
... between infection process and immune ...Both infection and immune dynamics must be considered stochas- tic and modeled by jump Markov ...primary HIV or SIV infection ...rely on ... See full document
10
Anti-HIV-1 activity of flavonoid myricetin on HIV-1 infection in a dual-chamber in vitro model.
... a HIV-1 long terminal repeat ...of HIV infectivity because TZM-bl cells are very sensitive to HIV-1 ...TZM-bl cells were used as a target for HIV-1 BaL ... See full document
18
Effect of maraviroc intensification on HIV-1-specific T cell immunity in recently HIV-1-infected individuals.
... untreated HIV-1 infection ...of HIV-1-specific response between the arms at any time point ...the HIV-1-specific response in the control arm was significantly reduced by ... See full document
11
Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.
... primarily on memory rather than naı¨ve T cells ...mouse cells were more permissive than human cells for virus ...severe T cell depletion if the other blocks to ... See full document
15
Human immunodeficiency virus impairs reverse cholesterol transport from macrophages.
... in HIV patients. Results presented in this report suggest that HIV-induced impairment of cholesterol efflux from macrophages may be another important contributor to the pathogenesis of ...of HIV ... See full document
14
Interferon-alpha administration enhances CD8+ T cell activation in HIV infection.
... of cells expressing this ...CD4+ T cells. Central memory cells were defined as CD 27+CD45RA2 and CCR7+, naı¨ve cells as CD27+, CD45RA+, and CCR7+, transitional memory cells as ... See full document
8
Follicular helper T cell in immunity and autoimmunity
... Tfh cells are a central source of IL-21 in germinal centers of secondary lymphoid organs, provid- ing cognate help to B cells in the germinal center dynamic microenvironment, acting specially on ... See full document
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