[PDF] Top 20 Kinetics of T cell-activation molecules in response to Mycobacterium tuberculosis antigens
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Kinetics of T cell-activation molecules in response to Mycobacterium tuberculosis antigens
... Paulo RZ Antas/ + , Eliane B Oliveira, Alexandre S Milagres*, Kees C Franken**, Tom HM Ottenhoff**, Paul Klatser***, Euzenir N Sarno, Elizabeth P Sampaio Laboratório de Hanseníase, Instituto Oswaldo Cruz-Fiocruz, Av. ... See full document
3
Identification of Mycobacterium bovis antigens by analysis of bovine T-cell responses after infection with a virulent strain
... characterization of individual antigenic proteins are essential for the understanding of the pathogenic mechanisms of mycobacteria and the immune response against ...them. In the ... See full document
9
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.
... motif. In our experiments, epitope prediction scores, peptide binding affinity measurements, T-cell recognition and functional profiling were used to guide peptide ...some of the ... See full document
15
Impairment of IFN-gamma response to synthetic peptides of Mycobacterium tuberculosis in a 7-day whole blood assay.
... one of the lower molecular weight peaks that appeared after 7 days of incubation was observed at ...days of stimulation with rESAT-6 and rCFP- ...levels in myeloid cells (neutrophils, ... See full document
8
Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa.
... differences in Mtb gene expression and therefore determining the immune response to stage-specific antigens can inform the design of new vaccine candidates ...instance, in LTBI, ... See full document
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Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.
... CD4 T-cells decreased with TB treat- ment, though the effect was greater for ...differences in CTLA-4 and PD-1 expression could account for ...thought to play a dominant role in limiting ... See full document
15
Linking inflammation to natural killer T cell activation.
... activity of innate and adaptive ...line of defense, kicking into action within hours of encountering pathogens, while adaptive immunity involves a higher degree of specificity for ... See full document
5
Evidence for T cell driven diversifying selection in Mycobacterium tuberculosis in vivo-expressed genes
... described in this thesis allowed the identification of predicted T cell epitopes under diversifying selection in iVEGI, their study in terms of envisaged HLA-binding, ... See full document
90
Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection.
... isolation of Mtb in 12 patients and 1 further patient was classified as having highly probable pulmonary TB on the basis of clinical and radiological features highly suggestive of TB that were ... See full document
10
A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B.
... Most of humanity is chronically infected with human herpesvirus 6 (HHV-6), with viral repli- cation controlled at least in part by a poorly characterized CD4 T cell ...Identification of ... See full document
24
Activation of anti-tumor immune response and reduction of regulatory T cells with Mycobacterium indicus pranii (MIP) therapy in tumor bearing mice.
... finding of this study was that along with activation of antigen presenting cells, NK cells and T cells, peritumoral injection of MIP also resulted in significantly less number ... See full document
11
Impact of IL-10 and SIRT2 in the protective immune response to Mycobacterium tuberculosis and Listeria monocytogenes infections
... during T cell priming impacted the CD4 T cell response to ...M. tuberculosis infection. To address this, lungs and lymph node cells from ...M. ... See full document
108
Mechanisms of early immune activation in response to hepatitis B virus.
... cytotoxic T lymphocytes (CTLs) and CD4 + T-helper (Th) cells play key effector and regulatory roles, respectively, in antiviral ...These T cells participate in viral pathogenesis either ... See full document
150
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
... infection in B cell-deficient mice does not alter lung bacterial burden ...delivery of a higher aerosol [23] or intravenous [25] dose of Mtb can result in B cell-deficient mice ... See full document
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Preliminary results in the immunodiagnosis of tuberculosis in children based on T cell responses to ESAT-6 and PPD antigens
... Recently, in vitro studies with cattle and humans mea- suring interferon gamma (IFN-γ) -secreting T cells have shown that the use of the specific recombinant antigen early secretory antigen target - ... See full document
4
Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules
... effect of W6/32 on the lymphopro- liferative response of six healthy subjects to PPD, ...tested. In these experiments, the magnitude of the sup- pression mediated by the HLA I ... See full document
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A Study of IgA Antibody Response to Different Mycobacterium tuberculosis Antigens in the Diagnosis and Monitoring of Pulmonary Tuberculosis
... 100µL of the sera diluted 1/20 in PBS containing 2% skim ...°C in a moist chamber, the sera were removed and the plates washed five times with ...1/7,500 in the same diluent as the serum was ... See full document
6
Antigen Specificity of T-Cell Response to Mycobacterium avium Infection in Mice
... targets of the protective immune response to M. tuberculosis (2, 3, 5, 12, 13, 17, 18, ...20). In addition, cell wall-associated proteins have also been shown to evoke an ... See full document
6
Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection
... overexpression of functionally active human Bcl-2 did not prevent the loss of T cells would argue that T-cell death occurs through a mitochondrial-independent pathway, namely, through ... See full document
10
Whole blood assay to access T cell-immune responses to Mycobacterium tuberculosis antigens in healthy Brazilian individuals
... detected in all but one individual tested (for WBA = 4,752 ± 1,391pg/ml ...[1,675.2 to 8,122.8]). In general, the comparisons of induced IFN γ levels with Mtb antigens were very similar ... See full document
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