[PDF] Top 20 Mechanism of cullin3 E3 ubiquitin ligase dimerization.
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Mechanism of cullin3 E3 ubiquitin ligase dimerization.
... forms of Cul3 with different molecular weights to distinguish them by their mobility in SDS-PAGE ...consists of full length Cul3 with an N-terminal Flag tag that was used for ...consists of full ... See full document
8
Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.
... The mechanism underlying this species- specific difference in phenotypic severity caused by CUL4B deficiency remains to be ...function of CUL4B and thus have less deleterious effect than the Cul4b null ... See full document
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REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I.
... regulatory mechanism of RIG-I-mediated signaling has not been adequately ...screens of a human fetal kidney cDNA library using full-length RIG-I as ...regions of RNF135 (Aa 125–432, GenBank ... See full document
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Characterization of the Arabidopsis thaliana E3 ubiquitin-ligase AtSINAL7 and identification of the ubiquitination sites.
... important mechanism in regulating key cellular ...involving ubiquitin (Ub) activation by a E1 enzyme, the transfer of Ub to a protein E2, finally an ubiquitin ligase E3 catalyzes ... See full document
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The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.
... fine-tuning of the replication ...independent of Tof1 and Csm3. Ctf4, the yeast homologue of human AND1, bridges the interaction of the primase, DNA polymerase-α, to the CMG heli- case ... See full document
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HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.
... degradation of endogenous Glis3. It is tempting to speculate that this regulation of Glis3 protein levels by Itch could serve as a mechanism for fine-tuning Glis3 function in pancreatic beta cells ... See full document
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The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation.
... cause of food- and water-borne illnesses in developed countries and in the ...group of pathogens called A/E pathogens that are able to colonize the intestinal mucosa and produce characteristic ‘attaching ... See full document
9
Regulation of global gene expression in human Loa loa infection is a function of chronicity.
... cells of endemic patients may offer clues to mechanisms underlying the depressed T cell responses typically seen in these ...patients. Ubiquitin and its associated molecules (Figure 6B) function in a wide ... See full document
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Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.
... domain of TRIM21. Thus our studies reveal a novel mechanism for regulating the activity of the E3 ligase TRIM21 via tyrosine phosphorylation of tyrosine 393 thus promoting its ... See full document
7
The E3 ligase AtRDUF1 positively regulates salt stress responses in Arabidopsis thaliana.
... a mechanism of post-translational ...by ubiquitin-activating enzyme (E1), ubuiquitin-conjugating enzyme (E2) and ubiquitin protein ligase ...predicted E3 ligases in the ... See full document
8
Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases
... The ubiquitin-proteasome system targets misfolded proteins for ...accumulation of such proteins is potentially harmful for the cell, their prompt removal is ...important. E3 ubiquitin-protein ... See full document
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E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3KAkt pathway Yingchun Li, Xiujuan Qu, Jinglei Qu, Ye Zhang, Jing Liu, Yuee Teng, Xuejun Hu, Kezuo Hou and Yunpeng Liu
... regardless of whether the cells carried the PML/ RARα fusion ...loss of function of Cbl-b by overexpression of DN Cbl-b strongly increases Akt activation after treatment and thereby ... See full document
8
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
... the ubiquitin ligase activity of Trip12 is required for BAF57 turnover in ES ...component of the SWI/SNF chromatin remodeling complex and involved in a variety of cellular processes ... See full document
8
HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.
... uncleavable ubiquitin moiety conjugated to the N-terminus of a protein signals the degradation of the fusion protein via the proteasome-dependent ubiquitin fusion degradation (UFD) ... See full document
8
Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants.
... regardless of the tested strain. This result suggests that vacuolar localization of GFP-Rer1p in ret1-1 rsp5-1 Figure ...Defect of GFP-Rer1 trafficking in ret1-1 rsp5-1 and sec27-1 rsp5-1 ... See full document
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Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping.
... dently of other Roc-Cullin complexes and that mutations of each gene would cause the same ...expression of Roc2 and identified two mutant alleles, both of which are ...upstream of the ... See full document
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Ubiquitin reference technique and its use in ubiquitin-lacking prokaryotes.
... degradation of a protein is measured through a brief labeling of cells with, for example, a radioactive amino acid, followed by cessation of labeling and analysis of cell extracts prepared at ... See full document
7
The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans
... such E3 ubiquitin ligase, the Anaphase-Promoting Complex (APC), is responsible for ubiquitinating multiple target proteins through which it regulates many different neuronal processes (Manchado, ... See full document
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FATORES QUE INFLUENCIAM A TOMADA DE DECISÃO EM ADERIR OU NÃO ¬À PLANOS DE PREVIDÊNCIA COMPLEMENTAR FECHADA: CONSTRUÇÃO DE UMA ESCALA DE CULTURA DE ACUMULAÇÃO DE RECURSOS E EDUCAÇÃO FINANCEIRA E PREVIDENCIÁRIA
... entrevistado E3 enfatiza a questão do consumismo imediato, ao observar que “Normalmente a pessoa que tem um bom salário e acaba não conseguindo poupar porque ele tem uma cultura de viver uma vida incompatível com ... See full document
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