[PDF] Top 20 A meta-analysis of ABCG2 gene polymorphism and non-small cell lung cancer outcomes

... between ABCG2 gene polymorphisms of 34 GG/(GA + AA) loci, 421 CC/(AC + AA) loci, and non-small cell lung cancer (NSCLC) therapeutic effects via ...PubMed ... See full document

... availability of small-molecule inhibitors and antibodies that could potentially target tumor lymphangiogenesis it seems appropriate that this treatment should be offered patients to whom it may prove ... See full document

... impact of maintenance gefitinib treatment versus placebo after 4 chemotherapeutic cycles of first-line platinum-based chemotherapy for patients with locally ad- vanced/metastatic NSCLC [22], on the basis ... See full document

... search of PubMed, EMBASE and CENTRAL (the Cochrane Central Register of Controlled Trials) database was performed in December 2011, using the following key words as the search terms: ‘‘NSCLC’’, ... See full document

... 40% of patients with cancer develop brain metastases (BM) during their disease ...as lung and, breast cancer or melanoma, are at high risk for ...50% of primary lung ... See full document

... Subgroup analysis is a method for exploring the sources of heterogeneity and for increasing the reliability of an ...prognosis of NSCLC [39]. While the patients in the included studies ... See full document

... treatment and are candidates for systemic therapy only, with a dismal 5-year survival rate of <5% (Rossi et ...evolution of individualized systemic treatment for advanced ...development of ... See full document

... year of publication, ethnicity, total numbers of cases and controls, and numbers of cases and controls who harbored the Ile462Val (exon 7) genotypes, ...author of the ... See full document

... type of protein that is expressed in normal adult tissue only in the testis as well as a variety of tumors of different histological ...view of their pattern of expression and ... See full document

... visualized and normalized using Gene- spring GX ...percentile of all measurements for that ...Because of the limitation of the resources, the statistic p-value may not be applicable ... See full document

... three of the eight up-regulated genes belong to the family of spliceosomal small nuclear ribonucleopro- teins (snRNPs): ASCC3L1, SNRPB, and ...complex of snRNPs plus a multitude ... See full document

... Lung cancer is the leading cause of cancer death worldwide for both men and ...one and a half million new cases are diagnosed each ...85% of all lung cancer ... See full document

... Mandel and Metais were the first to describe their observation of the presence of extracellu- lar nucleic acids in humans ...in cell-free nucleic acids isolated from all different body fluids ... See full document

... is of great importance for genome integrity and plays a crucial role in cancer initia- tion and ...TERT gene as risk factors for many cancer types ...studies of TERT ... See full document

... results of LUX-Lung 7 [27], a phase 2b trial comparing afatinib with gefitinib as first-line treatment in patients harboring EGFR mutations, that showed improvement in PFS and ORR with afatinib over ... See full document

... values and ranges were derived for quantitative variables and mRNA gene ...means of absolute frequencies and ...among gene expression ...mRNA gene- expression levels as ... See full document

... SNPs of HR genetic polymorphisms ...T241M and NBN E185Q) to be associated with various types of cancer risks, including cancers of the lung, breast, ovary, leukemia and ... See full document

... most of the studies, arterial and venous invasion has not been separately studied pathologically due to the inability in some cases to discriminate between arterial and venous ...most of the ... See full document

... modification of NER pathway may have impact on tumor sensitivity to platinum based chemotherapy, and conse- quently influence clinical outcome and patient survival ...ERCC2) gene encodes for ... See full document

... survival of cancer cells in breast, prostate, ovary, and brain tissue ...survival of NSCLC cell [29]. Recently, a clinical study of p-AKT expression in tissue from patients with ... See full document