[PDF] Top 20 Methylglyoxal effects on protein aggregation and amyloid formation
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Methylglyoxal effects on protein aggregation and amyloid formation
... diseases, and Amyotrophic Lateral Sclerosis (ALS), the molecular mechanism(s) leading to neuronal degeneration remain ...dysfunction and degeneration in distinct subsets of neurons in different brain areas ... See full document
195
Protein glycation and methylglyoxal metabolism in Parkinson's disease
... affect protein structure and functions, nevertheless, AGEs-modified proteins also exert cellular effects mediated by specific receptors including the macrophage scavenger receptor, MSR type II, ... See full document
211
The neuronal S100B protein is a calcium-tuned suppressor of amyloid- aggregation
... spectrum, and at ...the formation of a multimeric complex that is too large to be detected in the NMR ex- periments (although no precipitation was visible in the NMR titra- tion experiments) or, ... See full document
14
Biochemical effects of protein glycation by methylglyoxal in Saccharomyces cerevisiae
... systemic amyloid disease characterized by the extracellular deposition of transthyretin (TTR) in several tissues, particularly in the peripheral nervous system (Costa et ...peripheral and autosomal nervous ... See full document
244
Widespread protein aggregation across the mouse lifespan
... Protein aggregation is induced by a wide variety of cellular stresses, including amino acid starvation, virus infection, endoplasmic reticulum stress, lipopolysaccharide (LPS), and oxidative ...ROS, ... See full document
76
Finite size effects in simulations of protein aggregation.
... in protein science is the understanding of the causes, and implications of protein ...aggregates and in the formation of highly regular structures called amyloid fibrils ... See full document
6
What Can the Kinetics of Amyloid Fibril Formation Tell about Off-pathway Aggregation?
... 2 and 1 is in good agreement with recent Monte Carlo simulations that extend the classical nucleation-elongation-fragmentation scheme to include a stochastic nucleation step ...sigmoidal aggregation ... See full document
26
The contrasting effect of macromolecular crowding on amyloid fibril formation.
... 400, and dextran 70 are widely used to mimic the excluded-volume effects in crowded physiological environ- ments ...sucrose and epichlorohydrin, making it less flexible and more compact than ... See full document
14
The effects of the novel A53E alpha- synuclein mutation on its oligomerization and aggregation
... gation and reduces amyloid fibril formation when com- pared to WT ...the formation of amyloid structures by the A53E mutant is marginal, since A53E is unable to bind ...−9 and ... See full document
15
Intravenous immunglobulin binds beta amyloid and modifies its aggregation, neurotoxicity and microglial phagocytosis in vitro.
... Privigen and pAbs-Ab showed protection of SH-SY5Y neuroblastoma cells and rat primary cortical neurons from Ab-mediated neurotoxicity most probably by preventing binding of Ab to rat primary cortical ... See full document
14
Physical effects upon whey protein aggregation for nano-coating production
... whey protein coatings and films in food products is highly dependent on understanding the aggregation behavior of these proteins; once this realization is crucial to control the size of the ... See full document
32
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
... structural and functional properties of proteins in health and pathological ...its aggregation, fibrillogenesis, Lewy body formation, and neurotoxicity in ...[60] and that this ... See full document
18
Studies on amyloid formation in familial amyloidotic polyneuropathy
... vitro amyloid formation from synthetic peptides and the whole TTR molecule has already been described by acidification of the protein solutions (Gustavsson et ai, 1991; Colon and Kelly, ... See full document
180
What drives an amyloid protein precursor from an amyloidogenic to a native-like aggregation pathway?
... SE. Amyloid formation under physiological conditions proceeds via a native-like folding ...by methylglyoxal results in native- like aggregation and inhibition of ibril for- ...of ... See full document
8
Disclosing the aggregation mechanism of β2-microglobulin in amyloid disease
... in amyloid disease concerns the mechanism(s) of ...classical amyloid hypothesis, according to which the toxic species is the amyloid fibril itself, is gradually evolving into the view that the ... See full document
200
Effects of apoE deficiency and occlusal disharmony on amyloid-beta production and spatial memory in rats.
... clearance and deposition ...[17,18]. On the other hand, amyloid precursor protein transgenic mice deficient in apoE show a dramatic decrease in fibrillary amyloid deposits, showing that ... See full document
8
Heparin induces harmless fibril formation in amyloidogenic W7FW14F apomyoglobin and amyloid aggregation in wild-type protein in vitro.
... LKKHG, and at the end of the G-helix, ...recognition and binding to the basic cluster sequences localized on turn regions of the protein that are easily ...induces amyloid ... See full document
13
Prediction of peptide and protein propensity for amyloid formation
... Protein aggregation and subsequent assembly into amyloid like structures is commonly seen as a major problem in large scale expression of peptides and proteins of potential interest ... See full document
16
Fluorescence studies of protein aggregation leading to amyloid formation: the role of anionic lipid membranes
... localizations and functions in cells, all these proteins have cationic residues or cationic amino acid ...lipid/ protein ratio and the buffer solution had a low ionic strength (20 mM HEPES, ... See full document
133
Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation
... fibril formation has also been a limiting factor in long-term storage of insu- lin for treatment of ...handling and more cost- effective storage of ...[14], and recently Vestergaard and ... See full document
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