[PDF] Top 20 Minicircular DNA as a potential gene therapy vector in cervical cancer
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Minicircular DNA as a potential gene therapy vector in cervical cancer
... Após produção, o mcDNA deve ser extraído e purificado para que possa ser avaliada a eficiência de transfeção e efeito celular deste vetor em estudos in vitro. Têm sido exploradas várias técnicas cromatográficas ... See full document
108
NANO-STRUCTURES FOR NON-VIRAL GENE DELIVERY FOR CANCER THERAPY: A REVIEW
... condense DNA. Subsequently, this vector is used for in vitro and in vivo gene ...aid in the endosomal ...condense DNA to form stable ...derivatives. In addition to ... See full document
7
Human papillomavirus mutational insertion: specific marker of circulating tumor DNA in cervical cancer patients.
... relapse in one case and was associated with an 8 mm liver metastasis in the other ...Tumor DNA might be more easily released from tumor tissue corresponding to relapse or metastasis than to primary ... See full document
5
Cancer gene therapy
... acids in gene therapy is a challenge because of its inability in the extracellular matrix and its inability to cross the eukaryotic cell membrane barrier and reach the nucleus in its ... See full document
86
Affinity purification and delivery of a p53-encoding plasmid DNA for gene mediated cancer therapy
... suppressor gene is a valuable biological target for gene-based cancer therapies since common small therapeutic molecules are unable to reinstate its activity, rendering p53 as one of the so-termed ... See full document
194
Avaliação da Ação de um Vetor Multigénico de DNA Minicircular em Células Cancerígenas do Colo do Útero
... with cervical cancer being the third most common malignancy having persistent high-risk HPV (HR- HPV) infection as a major ...stranded DNA virus with the types HR-HPV16/18 being the most common and ... See full document
107
The challenge of vector development in gene therapy
... Viral gene expression occurs in a coordinated fashion and is mainly directed by the E1A and E1B genes, localized in the 5' portion of the adenoviral genome (Figure ...involved in adenoviral ... See full document
13
The immunogenicity and anti-tumor effects of a lung cancer DNA vaccine harboring a MUC-1 and GM-CSF fusion gene
... of DNA vaccines to elicit strong immune responses in clinical trials limits the application of DNA ...new DNA vaccine based on MUC1, which has been suggested as a potential target for ... See full document
7
Proteomic study of the therapeutic effect of a DNA vector on cervical cancer cells
... for cervical cancer ...for cancer development by degrading and inhibiting p53 and pRb tumour suppressor proteins, ...tumorigenesis. In fact, miR-375 has the ability to silence HPV E6 and E7 ... See full document
89
DNA minicircular multigénico com potencial ação terapêutica no cancro do colo do útero
... of cervical cancer since its E6 and E7 oncoproteins compromise the expression or activity of p53 and pRb tumor suppressor ...Many cervical cancer therapeutic approaches have demonstrated to be ... See full document
121
Cervical cancer: summary of the NIH consensus
... behavior in young people. In addition, research is needed on the optimal methods of evaluating and treating HIV-positive women with cervical lesions; im- proved screening in populations that ... See full document
3
Meilan Xue, Yinlin Ge, Jinyu Zhang, Qing Wang and Lin Hou
... the gene of n-3 fatty acid desaturase (CvFad3), which can synthesize the precursor of n-3 polyunsaturated fatty acids (PUFAs) or convert n-6 to n-3 ...CvFad3 gene from C. vulgaris can be functionally and ... See full document
10
INDUCING APOPTOSIS IN CANCER THERAPY
... results in the release of mature, active caspase-8 (composed of a p20/p10 heteromer) into the ...ways. In “Type I” cells, caspase-8 directly activates effector caspases, especially caspase-3, to an extent ... See full document
5
Cervical cancer research
... Results from the NCI study as well as the Spain component of the IARC study supported the notion that male sexual behavior has an influence on cervical cancer risk, s[r] ... See full document
3
Desenvolvimento de novas metodologias de purificação de DNA minicircular usando suportes monolíticos
... Tal como descrito no tópico anterior, é essencial proceder à recuperação do mcDNA após a sua produção com a finalidade de preparar amostras representativas para utilizar nas experiências cromatográficas. Neste caso ... See full document
97
DNA methylation-independent reversion of gemcitabine resistance by hydralazine in cervical cancer cells.
... weak DNA demethylating agent is accompanied by changes in the expression of hENT1 and dCK genes, a RT-PCR of these two genes was ...results in figure 3A shows that as expected hydralazine led to the ... See full document
11
A CLINICOPATHOLOGICAL STUDY ON CERVIX
... problem in the women of all ...lesion in all age groups, usually between 20-60 years, but rare before menarche or after ...changes in epithelium leading to carcinoma. The present study is undertaken ... See full document
7
Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals.
... transmembrane potential (Dym) and the release of proapoptotic factors, including cytochrome ...transmembrane potential or swelling, have been shown to be hallmarks of mitochondria-dependent apoptosis ... See full document
7
Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.
... gastric cancer, which agrees with the concept that HDAC is overex- pressed in gastric cancer tissues ...on gene expression, they may affect as yet unrevealed cellular processes ...[31,32]. ... See full document
10
Sexually Transmitted Infections Detected by Multiplex Real Time PCR in Asymptomatic Women and Association with Cervical Intraepithelial Neoplasia Infecções sexualmente transmissíveis detectadas por PCR multiplex em tempo real em mulheres assintomáticas e
... STIs in asymptomatic patients, using M-qPCR to identify five genital infections: ...HPV DNA by conventional PCR. 17 The frequency of these STIs was detected in two groups of women: one high-risk group ... See full document
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