[PDF] Top 20 Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters

... Oral mucositis (OM) is an important side effect of cancer treatment, characterized by ulcera- tive lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, ... See full document

... increase of MPO in the gastric tissue more powerfully in 10 mg/kg dose compared to 5 mg/kg ...Both oral and parenteral application of indomethacin is reported to be increasing ... See full document

... 1). On the other hand, the saline- injected mice showed a highly preserved intestinal struc- ture with intact villi and crypts, a cylindrical epithelial cell line covering the whole intestine, and intact Paneth ... See full document

... agent 5-fluorouracil (5- FU) in biological fluids of humans and animals have been reported ...administration of 5-FU alter in any way the morphology and ... See full document

... Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5- fluorouracil (5-FU) and ...ficacy of the therapeutic measures to ... See full document

... set of experiments invesigated the cascade blockade of leukotriene synthesis at a step further upstream, thus inhibiing all classes of leukotrienes, and not only the cys-LT, for which inhibiion was ... See full document

... regulation of radical production, elimination of radical precursors, metal chelation, or elevation of endogenous antioxidants ...body of evidence suggests that polyphenols regulate cell ... See full document

... success in the treatment of mucositis induced by ...by 5-FU [20]. Lactobacillus fermentum BR11 showed a partial rescue of histological pathology while being ineffective ... See full document

... completed in 2 - 5 days and terminates with the cell remotion by apoptosis and/or exfoliation ...and in mice is required to stem cell proliferation and oxide-reduction reactions ...Methotrexate- ... See full document

... e effect against t est icu lar t ox icit y induced by t et racy cline dose of 20 m g/ 100 gBW for 14 day s in m ...doses of 20, 50 and 100 m g/ 100 gBW used in pret reat m ent by ... See full document

... transcription of MMP-9, COX-2, and iNOS (Sonis, ...iNOS in the oral mucosa of hamsters compared to the 5-FU ...studied in the context of their roles ... See full document

... expression of GILZ, a glucocorticoid-induced leucine zipper, which is a member of the TSC-22 protein family that is important for mediating anti-inflam- matory ...production of proinflammatory ... See full document

... effects of antineoplastic agents in oral cavity are frequently observed during cancer ...cells in normal tissues like the epithelial cells in the oral ...mucosa. Mucositis ... See full document

... 1994). On the other hand, studies with MTX on rat testicles found decreases in testicular weight, (Vardi et ...effects on all spermatogenic cells, particularly on spermatocytes and ... See full document

... Total proteins (50 or 75 µg) were denatured at 100 ºC and resolved on 12.5 % sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Then, proteins were electrotransferred to a polyvinylidene ... See full document

... Also,research in the last decade has demonstrated that melatonin, by its free radical scavenging and antioxida- tive properties, ameliorates radiation toxicity in different ...irradiation induced ... See full document

... hepatotoxicity of triptolide limited its clinical ...role in triptolide-induced liver injury. To investigate the effect of vitamin C, which was one of the most effective ... See full document

... results of the analysis of structural chromosomal aberration levels in peripheral human lymphocytes in culture treated with different concentrations of MeHg and ...and in ... See full document

... (n=24) of 3 months age were equally divided into four ...was induced in the remaining three groups with administration of 500 mg/kg po APAP from day ...mg/kg of SLM, and 20 mg/kg ... See full document

... levels of intracellular trehalose in cultures stressed by freezing (Pacheco, et ...2009). In this work, hsp12∆ cells were more resistant to ethanol than Wt cells, which could be explained by a ... See full document