[PDF] Top 20 Regulatory T-cell development in the human thymus
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Regulatory T-cell development in the human thymus
... implicated in human tTreg differentiation and/ or proliferation, namely JAK3/STAT-5, Notch, CD80/CD86, ICOS/ICOSL, CD40/CD40L, thymic stromal lymphopoietin (TSLP), as well as the common-gamma chain ... See full document
7
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
... humanized T-ALL LIC mouse model. (A) Human NOTCH1-negative regulatory region/Fc (N1-NRR) or NOTCH2-NRR/Fc fusion protein (N2-NRR) expression plas- mids were transiently transfected into Freestyle ... See full document
14
Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells.
... addition in patient- derived iPSCs followed by differentiation into transplantable hematopoietic progenitors or mature T cells would provide new approaches to treatment of these devastating ...blood ... See full document
10
The influence of Toll-like receptor 4 activation in human CD4 T cell function
... cells in bone marrow that later migrate to mature in the thymus, hence their ...named T-cell receptors (TCRs) that can bind specific foreign peptides presented by ... See full document
74
Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal
... studies in human newborns and infants, yet it is believed that qualitative and quantitative differences when compared to adult immune responses ...exist. The dogma in neonatal immunol- ogy has ... See full document
10
Oral tolerance to cancer can be abrogated by T regulatory cell inhibition.
... cells in Balb/C mice, tumours developed and were allowed to attain a size of 1–2 cm 3 , at which stage the animals were sacrificed and their tumours were ...removed. The tumours were homogenized ... See full document
11
Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production
... and in spleen ...inhibit the development of polarized Th2 inflammatory cells in a TGF-β-dependent manner ...using the T-Bmc model, we found that Treg cells are able to suppress ... See full document
14
Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.
... of regulatory T-cells (Treg cells) in rats, but a first-in-man trial of the human CD28SA TGN1412 resulted in an unexpected cytokine release ...re-investigate the ... See full document
9
CD4+CD25hiCD127low regulatory T cells are increased in oral squamous cell carcinoma patients.
... occurs in about 400,000 individuals world-wide, and contribute to more than 222,000 deaths annually ...through the compilation of gene expression, chromosomal copy number and sequencing data for many types ... See full document
10
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.
... days in RPMI+10% FCS in presence of IL-2 (10 U/ml) and IL-15 ...+ T cells were isolated employing the human microbeads CD8 (Miltenyi Biotech) and co- cultured with autologous Tregs (+/- ... See full document
12
From thymus to periphery: molecular basis of effector γδ‐T cell differentiation
... subsets in naïve mice, which retained their cytokine produc- tion characteristics upon in vitro culture and exposure to cytokines implicated in αβ T cell polarization, or upon adoptive ... See full document
14
CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice.
... CD25+ T cell-depleted C57BL/6 mice by injection of the anti-CD25 mAb PC61 and examined lung responses to silica in ...Since the recently activated effector T cells may also ... See full document
11
Strategies for T-cell reconstruction : insights from human clinical models
... vaccination. The FOXN1 mutation identified is a homozygous C-to-T transition at nucleotide position 792 (GenBank accession ...(R255X) in exon 4 (formerly exon 5) 8 ...was the subject of ... See full document
224
Modulating The CD8+ T Cell Response in Human Papillomavirus-Induced Lesions: Studies in The K14-HPV16 Transgenic Mouse Model
... for the study of human diseases [64]. In the past couple of decades, new HPV transgenic mouse models have been created to more accurately infer on the function of some virus’ oncogenic ... See full document
94
Targeting MicroRNAs for Modlation of the Anti-Tumor Human Gamma-Delta T Cell Differentiation
... developments in immunology, as for instance the successes of sipuleucel‑T and ipilimumab in Phase III clinical trials, have validated the principle that immunotherapy can also extend ... See full document
87
Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis.
... by the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and The Academy of Sciences for the Developing ... See full document
7
Elucidating the role of macrophages and CD4+CD25+ regulatory T cells on colorectal cancer cell invasion
... outcome in several human cancers, such as ovarian 119 , breast, gastrointestinal, lung, liver, pancreatic cancer and melanoma 120 ...Contrarily, in CRC the results are controversial with high ... See full document
79
4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4+CD25+FoxP3+ T Regulatory Cell Suppression.
... from The Jackson Laboratory. Human CD2 transgenic ...for in University of Louisville’s specific-pathogen-free vivarium in accordance with NIH ...by the Uni- versity of Louisville’s ... See full document
13
Dissecting the thymic microenvironment - the impact of defective T cell development in the maintenance of the cortical thymic epithelium
... Within the thymus, the earliest thymic seeding progenitors are uncommitted cells that retain both myeloid, NK, B and T cell lineage potential ...[60]. In order to be instructed ... See full document
86
Modulation of regulatory T cells in autoimmune disease
... of T cell lines or clones specific for various myelin proteins (Swanborg, 1995; Steinman, 1996; Storch et ...1998). The clinical course of EAE varies according to the animal model and to ... See full document
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