[PDF] Top 20 The role of cellular prion protein in Alzheimer’s disease
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The role of cellular prion protein in Alzheimer’s disease
... cage in a temperature-controlled room (23士2°C) with 12-h light/dark ...during the light portion of the ...water in their home ... See full document
86
A Role for Extracellular Amastigotes in the Immunopathology of Chagas Disease
... investigate the relationship of T. cruzi with the kinin system was initially moti- vated by enzymatic specificity studies carried out with cruzipain 2 (Lima et ...that of tis- sue kallikrein, ... See full document
13
The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease.
... included the following: mouse anti-myc (Roche), mouse anti-HA (Roche), mouse anti-human a-syn phospho (Ser129) (anti-pS129a- syn) (Wako Chemicals), mouse anti-a-syn (BD Transduction Laboratories), mouse anti-human ... See full document
14
Development of Quercetin Brain Delivery Systems for the Treatment of Alzheimer´s disease
... properties of quercetin, magnetic nanoparticles have to be considered as potential and promising nanosystems for delivering quercetin in tumor ...cells. In a preliminary study, Barreto et ...studies ... See full document
70
"Deciphering the role of αβ-crystallin in huntington’s disease"
... trafficking of vesicles, transcriptional regulation and it also plays important functions in apoptosis and embryonic development (14, 49, ...involved in embryonic development, since homozygous HTT ... See full document
133
The cellular prion protein negatively regulates phagocytosis and cytokine expression in murine bone marrow-derived macrophages.
... [42]. The theoretical basis of that study was that CD47 is a ligand for the extracellular region of signal regulatory protein alpha (SIRPa) and that the binding of CD47 on ... See full document
9
PET-MRI in Neuroimaging: technique role in Alzheimer Disease
... PATTERNS IN PATIENTS WITH LOW COGNITIVE DEFICIENCY THROUGH PET-MRI STUDIES WITH APPLICATION OF 18 F-F LORBETABEN , T HE TOP LINE PRESENTS TRANSAXIAL PET-MRI IMAGES AND THE LOWER LINE CORONAL SECTIONS ... See full document
6
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
... change of Bcl-2 family proteins in PrP knockdown siPrP cells was also consistent with its increased ...survival. The increased Bcl-2 and A1 expression and the decreased pro-apoptotic BMF and ... See full document
10
Regulation of Aß-scavengers in the choroid plexus of Alzheimer´s disease patients.
... One of the most common features in AD are sleep and circadian rhythm disturbances, and it has been reported that up to 45% of patients may have sleep ...during the day (14%) makes ... See full document
76
Identification of the prion protein Doppel in spermatozoa and its impact in fertility
... (prion protein gene) is responsible for the expression of the cellular prion protein (PrP C ...involved in the transmission and pathogenesis of ... See full document
72
Manganese enhances prion protein survival in model soils and increases prion infectivity to cells.
... Additionally, the study relied on the charge conferred to the protein by SDS ...point of ionisation ...property of protein, PrP was removed successfully from the ... See full document
9
CHRONIC WASTING DISEASE: THE PRION DISEASE OF CERVIDS / Doença da debilidade crônica: a doença priônica dos cervídeos.
... In the late 60´s, a deer of the Odocoileus hemionus species kept in a deer research facility in the USA showed a behavior that at first seemed like an aggressive ... See full document
9
O efeito do stress celular na proteína precursora de amilóide de Alzheimer = The effect of cellular stress on the Alzheimer's amyloid precursor protein
... effect of phosphorylation on APP metabolism and processing has been well documented and, as already discussed, several lines of evidence have suggested that oxidative stress is involved in ... See full document
78
Structural analysis of mitochondrial mutations reveals a role for bigenomic protein interactions in human disease.
... are the energy producing organelles of the cell, and mutations within their genome can cause numerous and often severe human ...At the heart of every mitochondrion is a set of ... See full document
14
Induced prion protein controls immune-activated retroviruses in the mouse spleen.
... though, the disease occurred not only with samples from amplification that had been initiated by a seed of misfolded PrP originating from diseased hamster brain, but likewise with samples from ... See full document
8
A receptor for infectious and cellular prion protein
... forms of prion disease are associated with coding mutation in the PrP ...mutations in the hu- man PrP gene have been found that segre- gate with the ...found ... See full document
7
Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.
... twice in phosphate-buffered saline (PBS with Ca 2+ and Mg 2+ ; Lonza), harvested by scraping into PBS, and pelleted at 5006g for 3 ...ice in cold lysis buffer (25 mM Tris/HCl, ...total protein ... See full document
8
Importância das vitaminas, antioxidantes e ómega-3 na Doença de Alzheimer : monografia : <<The>> role of vitamins, antioxidants and omega-3 in Alzheimer´s Disease
... De acordo com o descrito torna-se evidente a necessidade de realização de mais investigação no sentido de determinar medidas nutricionais seguras e úteis para a prevenção e tratamento da DA. Embora nada tenha sido ... See full document
71
Insights into the physiological function of cellular prion protein
... functional role for PrPc in copper metabo- ...repeats in the amino-termi- nal half of the protein ...(23-25). The repeated region contains five or six octapeptide ... See full document
11
Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux
... 2003). The accumulation of neuromelanin (which is synthesized from dopamine quinone) throughout the aging process is an indication of the production of dopamine quinone in ... See full document
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