[PDF] Top 20 The role of LRRK2 in Parkinson’s disease : from function to dysfunction
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The role of LRRK2 in Parkinson’s disease : from function to dysfunction
... down LRRK2 promotes formation of smaller ...and LRRK2 under endogenous and over-expression ...on the complex interaction of these two central PD proteins and, in particular, on ... See full document
118
Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages.
... variability in the pat- terns of these alterations across the light-dark ...discussed, the NREM sleep deficit observed in TgCRND8 mice is more prominent during the active ... See full document
22
The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
... populations in developing countries are exposed to various adverse ...disadvantage in education, income, wealth, and occupation was associated with poor cognitive function in late life ... See full document
10
The role of bacteria in pine wilt disease: insights from microbiome analysis.
... is the only recognized causative agent of the disease and considered an A1 quarantine pest in the European Union (EPPO 2013 , 2014 ...). The PWN feeds on epithelial cells ... See full document
13
Cardiomyocyte dysfunction during the chronic phase of Chagas disease
... Mukherjee S, Gomes ER, Rocha NN, Ramos IP, Lisanti MP, Campos CF, Arantes RM, Guatimosim S, Weiss LM, Cruz JS, Tanowitz HB, Teixeira MM, Machado FS ...2012. Role of SOCS2 in modulating ... See full document
3
Elucidating the role of glycans in leucocyte function
... unique in their ability to prime both naïve and memory T cell immune ...arise from a common bone marrow myeloid hematopoietic progenitor, and after development, DC precursors egress the bone ... See full document
247
Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration.
... that LRRK2 WD40 mutants exhibit a significantly shorter life span than WT con- ...trols. To evaluate a possible toxic effect, Wse was tested at different concentrations ...w/w in their standard diet) ... See full document
16
Calciphylaxis: from the disease to the diseased.
... flow to skin and subcutaneous tissues and potentiates arteriolar ...kidney disease, inflamma- tion and platelet aggregation, which contribute to renal function impairment, endothelial ... See full document
40
Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice
... Considering the conflicting results previously obtained with isolated HD mitochondria (Panov et ...2005), the effects of mutant Htt on mitochondrial Ca 2+ -handling are still ...increase in ... See full document
9
Unsupervised feature extraction with autoencoder : for the representation of parkinson´s disease patients
... effectiveness in both, supervised and unsupervised tasks, they proved to be well suitable to medical big data to extract useful knowledge from it (Litjens et ...related to ... See full document
83
Exercise Attenuates Renal Dysfunction with Preservation of Myocardial Function in Chronic Kidney Disease
... blinded to the animal’s group, as previously described [13], using an HP Sonos-5500 echocardiograph (Hewlett Packard, Andover, MA, USA) with a 12-MHz linear ...transducer. The rats were imaged ... See full document
7
"Deciphering the role of αβ-crystallin in huntington’s disease"
... trafficking of vesicles, transcriptional regulation and it also plays important functions in apoptosis and embryonic development (14, 49, ...involved in embryonic development, since homozygous HTT ... See full document
133
Parkinson s disease and dopamine transporter neuroimaging: a critical review
... a role in the differential diagnosis with some other types of ...interested in developing sensitive diagnostic techniques for early PD by assessing DAT concentrations in ... See full document
8
Astrocyte heterogeneity in the brain: from development to disease
... response of astroglia in pathological conditions is very ...Indeed, in some circumstances, it is possible to observe morphological changes of these cells that become hypertrophic and ... See full document
11
Endothelial dysfunction in chronic kidney disease
... kidney disease (CKD) is a major global health problem affecting over 13% of the adult Western ...civilization. In CKD patients, cardiovascular (CV) disease is the main cause ... See full document
34
The role of cellular prion protein in Alzheimer’s disease
... result in accumulation of proteins in the brain which is followed by a progressive degeneration and/or death of nerve ...lead to multiple cognitive disturbances such as movement ... See full document
86
The Impact of Deep Brain Stimulation on the Quality of Life and Swallowing in Individuals with Parkinson ’s Disease
... At the end of the clinical evaluation, the intake of food was scored according to the ...scores the level of oral food intake of the patients ... See full document
5
A Role for Extracellular Amastigotes in the Immunopathology of Chagas Disease
... 2: role of abortive cycles of amastigote replication in the immunopathology of Chagas ...disease. The model predicts that the blockade of macrophage ... See full document
13
From Allergy to Schistosomes: Role of Fc Receptors and Adhesion Molecules in Eosinophil Effector Function
... After the description of CD23 on human eosi- nophils, we have investigated the existence of other IgE-binding ...belonging to the S-type lectin family, was detected on ... See full document
6
Muscle function and quality of life in the Crohn’s disease
... are in- dicative parameters of muscle function. The muscle weakness and fatigability results in loss of perfor- mance and consequently worst quality of ...derived ... See full document
9
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