[PDF] Top 20 Targeting nucleocytoplasmic transport in cancer therapy
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Targeting nucleocytoplasmic transport in cancer therapy
... protein transport is crucially involved in the pathophysiology of a broad range of human cancers, it offers novel molecular targets at many different levels to normalize or to interfere therapeutically with ... See full document
18
Reversing the intractable nature of pancreatic cancer by selectively targeting ALDH-high, therapy-resistant cancer cells.
... a cancer with a dismal ...of cancer stem cells (CSCs) to explain the mechanism of resistance and evaluated the efficacy of a candidate anticancer drug to target these therapy-resistant ...cells ... See full document
11
Editor’s Pick: PSMA-Specific Ligands in Prostate Cancer Diagnosis and Therapy
... 16. Smith-Jones PM et al. Radiolabeled monoclonal antibodies speciic to the extracellular domain of prostate-speciic membrane antigen: preclinical studies in nude mice bearing LNCaP human prostate tumor. J Nucl ... See full document
8
Perspectives of Dendrimer-based Nanoparticles in Cancer Therapy
... accumulates in tumor tissue is influenced by the size, molecular weight and surface charge, which affects the residence time in the circulatory system, transport through the endothelial barrier, ... See full document
16
Inhibition of mesothelin as a novel strategy for targeting cancer cells.
... involved in development of malignant phenotype and ...apoptosis in response to tumor necrosis factor alpha (TNF-alpha) ...Also, in C57MG mouse mammary epithelial cells, MSLN was up-regulated by ...of ... See full document
11
Feasibility Study of EndoTAG-1, a Tumor Endothelial Targeting Agent, in Combination with Paclitaxel followed by FEC as Induction Therapy in HER2-Negative Breast Cancer.
... reduction in MRI-estimated Ktrans tumor perfusion at the end of EndoTAG-1/Paclitaxel administration was also noted among 13 patients with available infor- mation about MRI-estimated Ktrans tumor perfusion (median ... See full document
11
RNA Interference: a Promising Therapy for Gastric Cancer
... Versican protein, a component of the extracellular matrix found on tumor stroma and cancer cells, is encoded by the VCAN gene. Its activity is regulated by several cytokines, including IL-11, which performs an ... See full document
7
Cancer gene therapy
... acids in gene therapy is a challenge because of its inability in the extracellular matrix and its inability to cross the eukaryotic cell membrane barrier and reach the nucleus in its native ... See full document
86
Targeting the NF-κB Pathway as a Combination Therapy for Advanced Thyroid Cancer.
... Thyroid cancer cells were seeded at a density of 5x10 6 cells per plate, and grown in RPMI-1640 media supplemented with 5% FBS for 6 ...seeded in the upper chambers of Matrigel-coated transwell cham- ... See full document
12
Rosamines targeting the cancer oxidative phosphorylation pathway.
... to cancer, so mitochondria are potential targets for anticancer ...describes in vitro cytotoxicity of second-generation rosamine analogs, their mode of action, and their in vivo efficacies in ... See full document
10
Anticancer peptides : prospective innovation in cancer therapy
... direct targeting of the cell membrane, such as interference with nucleic acid synthesis, hormonal recep- tors, or angiogenesis, have been hypothesized to be part of mediated immunity (Gaspar et ... See full document
15
Head and Neck Cancer Treatment with Particle Beam Therapy
... ions in Japan and about 440 patients in ...Accelerator in Chiba (HIMAC) was the central therapy site of the world's first carbon-ion treatment in 1994 and the facility has now treated ... See full document
6
Minicircular DNA as a potential gene therapy vector in cervical cancer
... limitation in therapeutic applicability, such as bacterial sequences essential for replication in the host, which can lead to an inefficient therapeutic response and possible clinical complications ... See full document
108
The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB
... RB in apoptosis has to be considered in a contextual basis (Figure ...context. In line with the idea that the role of RB in apoptosis has to be considered in a contextual basis, ... See full document
19
Dance as treatment therapy in breast cancer patients – a systematic review
... chers in a blind and independent manner considering that the differences found were settled through consensus between the ...researchers. In each article were observed the study design, objective, sample, ... See full document
13
Targeting cancer-related inflammation: Chinese herbal medicine inhibits epithelial-to-mesenchymal transition in pancreatic cancer.
... QYHJ, a seven-herb Chinese medicinal formula, comprised Scutellria barbata (Ban zhi lian), Heydyotis diffusa (Bai hua she she cao), Amorphophallus kiusianus (She liu gu), Coix lacryma-jobi (Yi ren), Gynostemma ... See full document
9
Aloe species in colorectal cancer therapy: friend or foe?
... During the last decade, several reports demonstrated that a subgroup of matrix metalloproteinases (MMPs) called gelatinases (MMP-2 and especially MMP-9), are largely responsible for colorectal cancer ... See full document
37
Riscos cardiovasculares do bloqueio androgênico.
... deprivation therapy, androgen supression therapy, hormone treatment, prostate cancer, metabolic syndrome e cardiovascular disease, no intuito de analisar quais seriam os reais riscos cardiovasculares ... See full document
4
Stem and progenitor cell-mediated tumor selective gene therapy
... metabolized in vivo by mammalian enzymes to active forms that inhibit DNA and RNA ...retrovirus in which CD expression is regulated by the retrovirus ... See full document
14
Early responses of the STAT3 pathway to platinum drugs are associated with cisplatin resistance in epithelial ovarian cancer
... ovarian cancer in clinical trials and signal transducer and activator of transcription 3 (STAT3) is associated with cisplatin resistance, we investigated whether overcoming cisplatin resistance by ... See full document
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