[PDF] Top 20 The latentiation process in drug design.
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The latentiation process in drug design.
... seletividade in vitro maior dos derivados peptídicos em relação ao fármaco de ...efeitos in vivo não foram satisfatórios, possivel- mente por deficiência na transformação do pró-fármaco em sua forma ... See full document
10
Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors
... from the tropical rainforest tree Calophyl- lum lanigerum, calanolide A, showed promising results as an ...source in a sufficient amount for clinical use and its low therapeutic index contrib- uted to ... See full document
18
Design Studio as a Process of Inquiry: The case of Studio Sao Paulo
... direct the students in the complexity of issues, relationships and stakeholders on site, and frames the research in the actual, ongoing debates in/on the ...city. ... See full document
14
A New Approach To The Rule-Based Systems Design And Implementation Process
... of the main problems encountered in practical RBS ...Mirella. The main goal of the system is to move the design procedure to a more abstract, logical and graphical level, where ... See full document
15
PARTICIPATORY MAPPING IN THE DESIGN PROCESS OF A SPATIAL DATA INFRASTRUCTURE (SDI)
... was the initiative which developed the idea of SDI. The INSPIRE directive came into being on May 15 2007 and has been implemented in several stages, with full deployment required by ...2019. ... See full document
128
Recent Advances and Perspectives in Cancer Drug Design
... explores the synergy between targeted and cytotoxic ...reduce the side effects associated with the non-selective nature of cytotoxic drugs (Chari ...2007). The conjugate is designed to remain ... See full document
18
Internship report of blog translation at the company Menina Design Group
... describe the nature and the extent of the relationships which exist between SL and TL texts or smaller linguistic units (Dictionary of Translation Studies, ...(1988), in his book A Textbook of ... See full document
46
Braz. J. Chem. Eng. vol.27 número3
... solving the flowsheet or physical infeasibility of the designed process subject to the assumed ...While the latter provides the engineer with useful information about the ... See full document
10
Non-clinical studies required for new drug development – Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies
... Usually, in vitro assays are performed in the early stages of the drug discovery process, when the selectivity and possible interactions of the candidate substance ... See full document
9
Molecular modeling: a tool for rational drug design in medicinal chemistry.
... RATIONAL DRUG DESIGN IN MEDICINAL CHEM- ISTRY. The molecular basis of modern therapeutics consist in the modulation of cell function by the interaction of microbioactive ... See full document
11
Analysis support for the design process of school buildings
... of design. During a design process, many evaluation procedures may take place and should be performed at adequate stages to reduce costs of design redefinitions (GRAÇA; KOWALTOWSKI; PETRECHE, ... See full document
16
J. Aerosp. Technol. Manag. vol.6 número4
... presents the development of a GUI for remote control of a rover in a planetary environment and the following testing phase to evaluate its performance regarding users’ SA and ...used in order ... See full document
16
Enhanced Re-Engineering Mechnanism to Improve the Efficiency of Software Re-Engineering
... time in the development of a system in any organization and that have to be utilized in another ...expert in the field of reengineering like design field and in ... See full document
6
KAIZEN METHODOLOGY IN QUALITY MANAGEMENT TO REDUCE WASTES
... improvements in quality, productivity, and cost can be achieved by early applying three methods in the process, namely: robust design, product design and product ...production ... See full document
7
Improving the drug discovery process by using multiple classifier systems
... Nevertheless, the complexity and elevated cost of the stages involving the development of the drug and approval process hampers the fast creation of new drugs (Adams & ... See full document
34
The Construction of a Web-Based Learning Platform from the Perspective of Computer Support for Collaborative Design
... to the field of design is known as the Computer Support for Collaborative Design ...collaborative design as team members’ negotiation, agreement, compromise, satisfying, and completion ... See full document
12
BEHAVIOR MONITORING AND BEHAVIORAL EXCHANGE
... on the participation of a community of users, require a very careful design process in order to get the community as involved as possible on the project, because the final ... See full document
53
“Multi-Criteria Analysis of the Design Decisions In Architectural Design Process during the Pre-Design Stage”
... During the second stage, the evaluation has been done for the top 5 alternatives based on the variables affecting the compactness and morphology of any buildings which are directly ... See full document
14
J. Braz. Chem. Soc. vol.15 número2
... represented in Figure 2, were employed. Figure 2a represents a simple two process variable – three mixture variable split-plot design for which only three mixture experiments are performed within ... See full document
5
Structure based drug design for the discovery of promising inhibitors of human Bcl-2 and Streptococcus
... Once the target has been identified, its implications on the disease phenotype must be validated through in vitro ...of the methodologies to validate a target is using antisense technology, ... See full document
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