[PDF] Top 20 Trehalose alleviates the phenotype of Machado–Joseph disease mouse models
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Trehalose alleviates the phenotype of Machado–Joseph disease mouse models
... amount of evidence show that trehalose exerts its neuroprotective effects by several mecha- ...nisms. Trehalose was detected in brain homogenates of mice treated with 2% trehalose in ... See full document
17
Insights into pathology and neurodegeneration features in a transgenic mouse model of Machado-Joseph disease
... in the yeast host was used to generate three YAC constructs with 15, 76 and 84 repeats, corresponding to the human wild-type, intermediate and early-disease- onset MJD alleles, ...respectively. ... See full document
118
Validation of neuronal inclusions as a biomarker for pre-clinical trials in a mouse model of Machado-Joseph disease
... from the transgenic MJD mouse models and MJD patient samples also showed a decrease in mtDNA copy number (89) and accumulation of mtDNA 3867bp deletions (88) in the initial stages ... See full document
76
Neuropathologic study of a transgenic mouse model of Machado-Joseph disease
... transgenic mouse models using the yeast artificial chromosome (YAC) containing the full-length human MJD1 gene coding for all alternative spliced isoform of mutant ataxin-3, with 64 to ... See full document
99
A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease.
... with the patient’s serum (Figure 3A). In addition, sera stored from the patient years prior to the onset of his symptoms showed no reactivity on immunoblot (courtesy of ...characterize ... See full document
8
Selection of the temperature of casting the bronzes to plaster moulds
... from the temperature of casting the bronze to the mould on Figure ...From the introduced cross - section of casts from the probe TDAg, it results that it together with ... See full document
6
The application of optical measurements for the determination of accuracy of gear wheels casts manufactured in the RT/RP process
... taking the measurements, an anti-reflection coating was applied on the tested gear ...wheel. The thickness of the coating ranged from 0,8 µm do 1,2 ...µm. The measurements were ... See full document
4
Shared control of maltose and trehalose utilization in Candida utilis
... conditions the increased activity of trehalase could not to be ascribed solely to an effect of catabolite derepression acting on trehalase genes since cells grown in glycerol, a gluconeogenic carbon ... See full document
9
The Influence of Small Amounts of Aluminium on the Spheroidization of Cast Iron with Cerium Mischmetal
... determine the influence of aluminium in the amount from about ...on the structure of cast iron treated with cerium mischmetal and subjected to graphitizing modification with 75% ... See full document
6
Engineered Trehalose Permeable to Mammalian Cells.
... increasing the number of acetyl groups to 6 resulted in a significant improvement in trehalose ...that the hydrolysis of the permeated acetylated trehalose by endogenous ... See full document
16
Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease
... analyze the effects on mitochondrial function upon treatment with coQ10 and lithium in this phase of our study, but rather focused on the potential effects of these two drugs on ... See full document
7
Repositorio ISMT: The Perceived Advantages and Disadvantages of Presymptomatic Testing for Machado-Joseph Disease: Development of a New Self-Response Inventory
... intentions. The model rest on the premises that in- dividuals are rational information processors (for ex- ample, the HBM assumes that the individual weighs up the pros and cons ... See full document
17
Disartria e doença de Machado-Joseph: relato de caso.
... de Machado-Joseph, em um indivíduo do sexo masculino, selecionado entre outros pacientes portadores desta doença com limitações significativas de ...de Machado-Joseph, associadas ao ... See full document
5
Genetic counseling and presymptomatic testing programs for Machado-Joseph disease: lessons from Brazil and Portugal.
... Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most common form of spinocerebellar ataxia (SCA) ...detect the ... See full document
8
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
... F2 mouse was determined using a desktop mCT imaging system (mCT 40; Scanco Medical, Bassersdorf, ...Switzerland). The trabecular region was defined by contouring the inner section of ... See full document
16
Repositorio ISMT: Psychological aspects of pre-symptomatic testing for Machado–Joseph disease and familial amyloid polyneuropathy type I
... frame of reference for other late-onset genetic ...offered, the authors (53) concluded that at-risk individ- uals were aware of the advantages of genetic counselling to facilitate ... See full document
9
MATERIALS AND METHODS Bacterial strains and antimicrobial screening
... effect of GB, proline and trehalose on the two strains has shown only at inhibitory ...is the main compatible solute in Streptomyces ...variety of plant species (2) and in many ... See full document
11
The modification process of AlSi21CuNi silumin and its effect on change of mechanical properties of the alloy
... Essence of modification of silumins boils to change of form or size of silicon crystals present as eutectic or primary ...resistance of hypereutectoid silumins result from their ... See full document
4
Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment.
... whether the cytoprotective effects of trehalose are attributed to autophagy induction, chloroquine (CQ) and wortmannin (WT) were used to inhibit ...blocks the fusion between autophagosome and ... See full document
9
A Method To Find The Area Of Sector Without The Usage Of Angle Made By The Chord
... at the alternate sides, of the tangents through the diameter of the circle, and then the line joining these points divides the circle in the ratio of ... See full document
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