1116 Arq Neuropsiquiat r 2004;62(4)
* Aspect os clínicos, elet romiográf icos e de evolução de pacient es com neuroesquist ossomose ( Resumo). Dissert ação de M est rado, Universidade de Pernambuco (área: Clínica M édica). Orient ador: Luiz At aíde Júnior; co-orient ador: Ot ávio Gomes Lins.
* * Address : Rua Hermógenes de M orais 230, 50610160 Recif e PE, Brasil. E-mail: ccc@t ruenet .com.br
CLINICAL ASPECTS, ELECTROM YOGRAPHIC AND EVOLUTION OF NEUROSCHISTOSOM IASIS PATIENTS
(ABSTRACT)* . DISSERTATION. RECIFE, 2004.
CAROLINA DA CUNHA CORREIA* *
M ansoni schist osomiasis is a parasit Ic disease t hat
assault nearly 10% of t ot al Brazilian populat ion,
mainly f rom nort hw est , and it const it ut es an
impor-t animpor-t public healimpor-t h problem. The neurological
presen-t apresen-t ion is especially severe because of mopresen-t or, sensipresen-t ive,
sphinct erian and erect ile dist urbances associat ed w it h
neuroschist osomiasis, t hat are diff icult t o recuperat e.
Object if ying t o describe clinical and elect
romyo-graphy aspect s of neuroschist osomot ic pat ient s,
ana-lyzing clinical evolution, the author studied 47 patients,
aging from 14 to 65 years old, 11 (23.4% ) f emales, w ho
at t empt ed emergency or ambulat ory consult at ion
at neurological service of Hospit al da Rest auração,
Recif e, Pernambuco, Brazil, f rom 2000 June t o 2003
June. One has evaluat ed clinical manif est at ions,
mag-net ic resonance image alt erat ions, cellular and
bio-chemical charact erist ics of cerebrospinal f luid, ult
ra-sound hepat osplenic f indings, mot or, sensit ive and
sphinct er evolut ion and elect romyography pat t erns,
besides t he relat ion of t hese f indings and t he mot or
clinical evolut ion af t er a median period of t hree
mont hs af t er hospit al discharge.
M ain clinical manif est at ions included isolat ed
sphinct er dist urbances (100% ), mot or def icit (95.7% )
and sensibilit y alt erat ions (83% ). The anat omical
le-vel most f requent ly involved w as low t horacic
re-gion f rom T6 t o T12 (57.4% ). Thirt y f our (91.9% ) of
37 pat ient s submit t ed t o magnet ic resonance
pre-sent ed hyposignal at T1 and hypersinal at T2, w it h
contrast capture predominantly at thoracic region,
iso-lat ed or ext ended t o spinal cord cone. On
cere-brospinal f luid, t he f indings w ere pleocyt osis (93.6% )
w it h lymphmonocyt ic pat t ern. Hepat osplenomegaly
w as absent f or 32 of 38 (84.2% ) pat ient s submit t ed
t o abdominal ult rasound. Elect romyographic pat
-t ern of 95.2% pa-t ien-t s w as compa-t ible -t o axonal
lumbosacral mult irradiculopat hy, w it h variable
den-ervat ion ext ension, but predominant f rom level L2
t o S2.
Wit hin revaluat ion, mot or dist urbances more f
re-quently disappeared; the sensitive ones got better and
sphinct er ones did not alt er. There w as w orst mot or
recuperat ion on pat ient w it h more ext ensive
dener-vat ion at elect romyography.
KEY WORDS: neuroschist osomiasis, elect
romyo-graphy, diagnosis.
CLINICAL AND DEMOGRAFHICAL CHARACTERISTICS OF PEOPLE WITH EPILEPTIC CRISIS COMING FROM
A CYSTICERCOSIS AND TAENIASIS ENDEM IC AREA IN BAHIA STATE (ABSTRACT)* . DISSERTATION.
SALVADOR, 2003.
EM ÍLIA KATIANE EM BIRUÇU* *
Epilepsy is f requent all over t he w orld, occurring
independent of gender, age, race or social st at us.
The highest prevalence rat es occur in count ries under
development and are due t o inf ect ious parasit ic
dis-eases, like cyst icercosis. Neurocyst icercosis is t he main
cause of secondary epilepsy in t he w orld because of
it s high prevalence in regions w it h precarious
sani-t ary inf rassani-t rucsani-t ure. The ssani-t udy of epilepsani-t ic crisis in
poor communit ies, w it h inadequat e medical care and
poor access t o medicat ion, allow ed t he analysis of a
clinical evolut ion close t o t he disease´s nat ural hist
o-ry. Besides, it represent s t he local communit y´s
real-it y and eliminat es select ion bias, diff erent f rom st
ud-ies conduct ed in ref erence cent ers.
Objective: To determinate the prevalence of
epilep-sy and t o describe t he clinical and demograf hical
Arq Neuropsiquiat r 2004;62(4) 1117
charact erist ics of people w it h seizures in t he cit y of
M ulungu do M orro, Bahia St at e, Brazil, an endemic
area f or cyst icercosis (1.6% ) and t aeniasis (4.5% ).
St udy design: 1. t ransversal cut f or prevalence
det erminat ion and 2. prospect ive cohort .
Method: Firstly, it was performed the health agents
t raining f or know ing t he epilept ic crisis t rial quest
ion-naire, and t hen t hese quest ionnaires w ere applied in
a sample of t he local populat ion. The individuals
sus-pect ed of seizures and 10% of t he negat ive sample
were evaluated by the group neurologists. At the same
t ime, people w it h clinical pict ure suggest ive of
epilep-sy w ere convoked by t he region´s radio epilep-syst em. All
t he epilept ic individuals ident if ied in t he populat ion
or convoked w ere accompanied in t he ref erence
ambulat ory inst alled in t he cit y of M ulungu do M orro
f or t his purpose. The pat ient s f ormed t w o groups;
t hose w ho came f rom t he communit y and t hose f rom
t he ambulat ory. The dat a w ere insert ed in an ACCESS
2000 bank and analyzed w it h t he st at ist ic program
SPSS version 6.0. It was considered 95%confidence
lim-it s and employed t he Z, qui-square and Fisher t est s,
according t o t he variables analyzed.
Result s: 456 f amilies w ere evaluat ed , making a
t ot al of 2138 individuals. The prevalence of act ive
epilepsy w as 6.2 / 1000 and accumulat ed, including
single seizure, 22.9 / 1000. It w as not observed
varia-t ion bevaria-t w een genders. The mosvaria-t aff ecvaria-t ed ages w ere
f rom 11 t o 30 years (75% ). The majorit y (75% ) of t he
seizures begun bef ore t he ages of 25. Comparing
t he result s f rom bot h groups (communit y and
ambu-lat ory) t here was no diff erences reambu-lat ed to gender, age
or beginning of t he crises. In bot h it w as observed a
predominance of one kind of seizure and of part ial
and secondary generalized crisis. Among t he pat ient s
w ho came f rom t he communit y t here w ere more f
re-quent single seizure or w it h long periods bet w een
crises, more recent crises, inact ive epilepsy and a
great er number of pat ient s not using any kind of ant
i-epilept ic drug.
Conclusion: In M ulungu do M orro epilepsy
pres-ent s high prevalence, occurring among all ages and
with a higher frequency of start in childhood and
ado-lescence. The seizures f rom t he communit y´s pat ient s
t end t o occur in t he isolat ed or recurrent f orm w it h
long periods bet w een t hem, t he highest numbers of
cases are f ound in t he inact ive f orm and w it hout t he
use of medicat ion. The pat ient s w ho looked f or t he
ambulat ory have a w orse prognosis because t hey
present seizures more f requent ly and usually are
using medicat ion.
KEY WORDS: epilepsy, epilept ic crisis, prevalence,
cyst icercosis.
The search f or new chemot herapeut ic drugs has
increased, especially f or t hose t hat have a nat ural
ori-gin. Perillyl alcohol (POH), is a nat urally occurring
monoterpene, found in the essential oils of citrus fruits
and ot her plant s, w it h pronounced chemot
herapeu-t ic acherapeu-t iviherapeu-t y and minimal herapeu-t oxiciherapeu-t y in preclinical sherapeu-t udies.
Standard treatment of anaplastic gliomas and
glioblas-t oma mulglioblas-t if orme consisglioblas-t ing of surgical resecglioblas-t ion,
radi-at ion t herapy and/or chemot herapy is rarely curradi-at ive.
This st udy aimed t o evaluat e in vit ro and in vivo
ef f ect s of POH t reat ment , cell prolif erat ion, changes
in morphology, prot ein synt hesis, and migrat ion of
dist inct lineage of glioblast oma cells.
It w as chosen in vit ro cult ure syst ems and in vivo
assays f or assessing cellular migrat ion. In vit ro t reat
-ment of POH at concentrations of (v/v) 0.003%, 0.02% ,
0.03% , 0.3% , 3% and 30% , consist ent ly inhibit ed
pro-lif erat ion of murine C6 and human A172 and U87M G
of glioblast oma cells.
In vit ro t reat ment of POH at low concent rat ions
0.03% v/v and 0.3% v/v also produced marked changes
in cell morphology and inhibit ed prot ein synt hesis.
Likew ise in vit ro assays w it h 0.3% v/v POH t reat ment
f or 15 minut es, init ially caused marked alt erat ion in
membrane permeabilit y and lat er (50 minut es)
dras-t ic changes in dras-t he cydras-t oarchidras-t ecdras-t ure of C6, U87M G
EFFECTS OF IN VITRO AND IN VIVO TREATM ENT OF M ONOTERPENE PERILLYL ALCOHOL ON
PRO-LIFERATION AND GENE EXPRESSION CONTROL OF HIGH GRADE GLIOM AS (ABSTRACT)* .
DISSER-TATION. RIO DE JANEIRO, 2003.
CLÓVIS ORLANDO PEREIRA DA FONSECA* *
* Caract eríst icas clínicas e demográf icas de indivíduos com crises epilépt icas em uma área endêmica para cist icercose e t eníase no Est ado da Bahia (Resumo). Dissert ação de M est rado, Universidade Federal da Bahia (Área: Neurociências). Orient ador: Ailt on M elo.
