rev bras hematol hemoter. 2017;39(2):175–176
w w w . r b h h . o r g
Revista
Brasileira
de
Hematologia
e
Hemoterapia
Brazilian
Journal
of
Hematology
and
Hemotherapy
Images
in
Clinical
Hematology
Oral
lesions
associated
with
Fanconi
anemia
Eric
T.
Stoopler
∗,
Lujain
Homeida,
Thomas
P.
Sollecito
UniversityofPennsylvania,SchoolofDentalMedicine,Philadelphia,UnitedStates
a
r
t
i
c
l
e
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n
f
o
Articlehistory:
Received3March2017
Accepted24March2017
Availableonline15April2017
Amiddle-agedmancomplainedofsymptomaticorallesions.
FamilyhistorywaspositiveforFanconianemia(FA).An
intra-oral examination revealed generalized erythroleukoplakia
with focal ulcerations affecting the palate (Figure 1).
Dif-ferentialdiagnosisincludedlichenoidlesions,dysplasiaand
squamous cell carcinoma (SCC). Previous biopsies
demon-stratedmildtomoderatedysplasia.Thepatientunderwent
genetictestingandwasdiagnosedwithFA.
FA is an autosomal recessive disorder characterized by
physicalabnormalities,bone marrow failureand
predispo-sitiontohematologicandsolidmalignancies.1Oralfindings
associatedwithFAincludemucosallesions,periodontal
dis-ease and dental anomalies.2 FA patients are considered
high-riskfororalSCC.3
∗ Correspondingauthorat:DepartmentofOralMedicine,UniversityofPennsylvaniaSchoolofDentalMedicine,240South40thStreet,
Philadelphia,PA19104,USA.
E-mailaddress:[email protected](E.T.Stoopler).
Figure1–Generalizederythroleukoplakiawithfocal ulcerationsaffectingthehardandsoftpalate.
http://dx.doi.org/10.1016/j.bjhh.2017.03.003
1516-8484/©2017Associac¸ ˜aoBrasileiradeHematologia,HemoterapiaeTerapiaCelular.PublishedbyElsevierEditoraLtda.Thisisan
176
revbrashematolhemoter.2017;39(2):175–176Conflicts
of
interest
Theauthorsdeclarenoconflictsofinterest.
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1.SchifferliA,KuhneT.Fanconianemiaoverviewofthedisease andtheroleofhematopoietictransplantation.JPediatr HematolOncol.2015;37(5):335–43.
2.GoswamiM,BhushanU.Dentalperspectiveofrarediseaseof Fanconianemia:casereportwithreviewClinMedInsights. CaseRep.2016;17(9):25–30.
