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www.rsbmt.org.br ̶ www.scielo.br/rsbmt

384

Address to: Dr. Israel Figueiredo Junior. Depto Materno-Infantil/FM/HUAP/UFF. Av. Marques do Paraná 303, Centro, 24030-210 Niterói, RJ, Brasil.

Phone: 55 21 2620-1323; 55 21 8212-3045

e-mail: ifi [email protected] Received 03 November 2012 Accepted 19 February 2013

Images in Infectious Diseases

Experimental infection of mice with

Anisakis simplex

Israel Figueiredo Junior

[1]

, Gerlinde Teixeira

[2]

and Mauricio Afonso Vericimo

[2]

[1]. Departamento Materno-Infantil, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ. [2]. Departamento de Imunobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ.

REFERENCES

A photograph of third-stage (L3) Anisakis simplex larvae in

the gastric cavity of BALB/c mice is provided here. Anisakis

nematodes (Figure A; arrows) are white and cylindrical and measure approximately 2 to 3 centimeters in length. Human

anisakiasis, an emerging disease often triggered by eating fi sh infected with Anisakis sp., is not widely studied in Latin

America. Mouse models have been developed to emulate the

human immune response to Anisakis infestation. These models, however, involve infection via the intraperitoneal route, rather

than the oral route, which is the natural pathway of nematode entry in humans. It is believed that the establishment of an

intestinal model of infection should involve the introduction of live larvae through the orogastric route. Our team has developed

a simple, reproducible model of infection that allows for the introduction of viable larvae into mice via this route (video:

http://www.uff.br/anisakis/ansakis%205_0002.wmv).

1. Audicana MT, Kennedy MW. Anisakis simplex: from obscure infectious

worm to inducer of immune hypersensitivity. Clin Microbiol Rev 2008; 21:360-379.

2. Daschner A, Cuellar C, Rodero M. The Anisakis allergy debate: does and

evolutionary approach help? Trends Parasitol 2012; 28:9-15.

3. Figueiredo Jr I, Cardoso L, Teixeira G, São Clemente S, Vericimo M. A technique for the intra-gastric administration of live larvae of Anisakis simplex in mice. Exp Parasitol 2012; 130:285-287.

A

Revista da Sociedade Brasileira de Medicina Tropical 46(3):384, May-Jun, 2013

Referências

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