alpha-synuclein
The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells.
... The relatively high co-occurrence of Parkinson’s disease (PD) and melanoma has been established by a large number of epidemiological studies. However, a clear biological explanation for this finding is still lacking. ...
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Effect of spermidine on misfolding and interactions of alpha-synuclein.
... on alpha-synuclein conformation The low propensity of a-Syn monomers to interact at physiologically relevant conditions is in line with our early observations [18,21] and explains the numerous observations ...
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The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice.
... anti- alpha-synuclein-1 antibody (1:2000, BD Transduction Laboratories) and a rabbit anti GAPDH antibody (1:2000, FL335, Santa Cruz Technology), followed by the incubation with secondary goat anti mouse and ...
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Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
... Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. Furthermore, mutations in the gene ...
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Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays.
... Alpha-synuclein (a-Syn) plays a pivotal role as the conversion of its soluble form into insoluble a-Syn aggregates represents a key event in the pathogenesis of Parkinson’s disease (PD) [1, 2]. a-Syn ...
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The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
... protein alpha-synuclein in intracellular clumps called ...and alpha-synuclein in order to dissect the molecular mechanisms associated with protection against alpha-synuclein ...
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Analysis of alpha-synuclein in malignant melanoma - development of a SRM quantification assay.
... any alpha-synuclein form that may occur in MM, including monomer forms, truncated ones, peptides thereof, as well as oligomers, polymers and genetic ...four alpha-synuclein isoforms. Thus, the ...
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The Interplay between Alpha-Synuclein Clearance and Spreading
... Abstract: Parkinson’s Disease (PD) is a complex neurodegenerative disorder classically characterized by movement impairment. Pathologically, the most striking features of PD are the loss of dopaminergic neurons and the ...
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Study of structural and dynamic properties of alpha-synuclein
... how alpha synuclein in its oligomeric form can interact and disrupt a cell membrane by creating pore-like oligomers, while still retaining some of the formed oligomers in ...
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Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.
... protein alpha-synuclein (AS) is strongly implicated in both sporadic and familial forms of Parkinson’s disease (PD), and with a variety of other neurodegen- erative diseases collectively termed ...
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Alpha-synuclein phosphorylation role on Parkinson’s disease
... of alpha- synuclein (aSyn) in the Lewy Bodies (LB), which are intracellular aggregates characteristically found in the dopaminergic neurons affected by the disorder ...
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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.
... synuclein pathology: the G-protein coupled receptor kinase 2 and the molecular chaperone Hsp70 [17–19]. In Drosophila, overexpression of G-protein coupled receptor kinase 2 (Gprk2) increases neuronal toxicity of ...
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Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra.
... a-synuclein siRNAs embedded as shRNAs in adeno-associated virus vectors were unilaterally injected into the rat substantia nigra pars compacta [19]. Quite surprisingly, this administration was found to cause a ...
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Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region.
... Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder, affecting 1–2% of the population over 65 [1,2]. The clinical symptoms of PD include muscle rigidity, resting tremor, bradykinesia ...
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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis.
... It is known that the rupture of endocytic vesicles by adenovirus [12,13], silica crystals, [30] or amyloid beta [26] can induce inflammasome activation in macrophages and microglial cells, resulting in the release of ...
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The effects of the novel A53E alpha- synuclein mutation on its oligomerization and aggregation
... α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease. In particular, multiplications and ...
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Neuropathology in mice expressing mouse alpha-synuclein.
... a-Synuclein (aSN) in human is tightly linked both neuropathologically and genetically to Parkinson’s disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (maSN), ...
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Alpha-synuclein phosphorylation role on Parkinson's disease
... αSyn is abundantly expressed in the human brain, especially in the neocortex, hippocampus, SN, thalamus and cerebellum [McLean et al, 2000a], [Yu et al, 2007], making up as much as 1% of the total protein content [Kim et ...
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Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.
... Purification and Nitration of Recombinant a-Syn Based on our findings, we hypothesized that in PD, NT modifications of a-Syn could be a key step converting the endogenous protein to an immunogen. Here, we used the C- ...
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A label-free immunosensor for electrochemical determination of alpha-synuclein
... The major goal of this work, which was the development of an immunosensor for α- Synuclein, was achieved. The immunosensor construction started with the testing of different nanomaterials to act as immobilization ...
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