DNA Repair
Identification of the DNA repair defects in a case of Dubowitz syndrome.
... the DNA damage response and repair capability of fibroblasts established from a Dubowitz Syndrome ...normal DNA damage signaling and cell cycle checkpoint activations after DNA ...in ...
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Evaluation of prevention of DNA damage and induction of DNA repair by natural compounds
... genomic DNA. Cells have developed molecular repair mechanisms involving specific enzymes such as glycosylases, nucleases, polymerases and ligases, allowing efficient removal of ...between DNA ...
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Rising from the Ashes: DNA Repair in Deinococcus radiodurans.
... single-strand DNA annealing (ESDSA) ...break repair. Some initial studies suggested that the first phase of repair did not involve the Deinococcus RecA protein, but more recent work has docu- mented ...
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DNA repair gene expressions are related to bone marrow cellularity in syndrome
... The low expressions of BRCA1 and BRCA2 genes have also been reported in solid tumours, such as epithelial ovarian car- cinoma, prostate cancer and breast cancer. 31 32 Using MLR ana- lysis, we detected that decreased ...
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XPD, RAD51, and APEX1 DNA repair genotypes and
... malfunctioning DNA repair ...key DNA repair mechanisms on risk for prostate cancer was investigated in this case-control ...population. DNA repair dysfunctions seem to prevail ...
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Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population
... The Brazilian population is very heterogeneous, as a result of sexual congress between different ethnic groups, including native Indians and immigrants from Europe, Af- rica and Asia. Our results are in accordance with ...
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DNA repair-related genes in sugarcane expressed sequence tags (ESTs)
... in DNA repair ...excision repair is apparently complete, but the absence of a Xpa homologue is intriguing, and a substitute protein performing its func- tion may yet be ...excision repair ...
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Effects of UV radiation exposure on DNA and DNA repair enzymes
... on DNA have been extensively studied, very little is known about the effect of these carcinogens on DNA repair enzymes, in particular on the Fe‐S containing DNA glycosylases, such as ...
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Distribution of DNA repair-related ESTs in sugarcane
... of DNA repair mechanisms (Britt, 1996; Tuteja et al., 2001). DNA damage results in various physiological effects, such as reduced protein synthesis, cell membrane destruction, damage to ...
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New polymorphisms of Xeroderma Pigmentosum DNA repair genes in syndrome
... Pigmentosum DNA repair genes (XPA rs1800975, XPC rs2228000, XPD rs1799793 and XPF rs1800067) polymorphisms and myelodysplastic syndrome (MDS) have not been ...in DNA samples in an allelic ...
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Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin.
... for repair of DNA damage induced by ...(E) DNA repair in IR- treated ...protocol. DNA damage was estimated by measuring the distance of the tail against the edge of far side of the ...
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A PHF8 homolog in C. elegans promotes DNA repair via homologous recombination.
... PHF8 is a JmjC domain-containing histone demethylase, defects in which are associated with X-linked mental retardation. In this study, we examined the roles of two PHF8 homo- logs, JMJD-1.1 and JMJD-1.2, in the model ...
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Carbinolamine formation and dehydration in a DNA repair enzyme active site.
... Dehydration of the carbinolamine intermediate to form the final imine product was observed in free, unsteered, QM/MM dynamics simulations, as was unforced acid-base transfer between the [r] ...
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Measuring DNA lesions induced by chemotherapeutic agents – DNA repair and DNA Damage
... of DNA damage and for obtaining results in a relatively short period of ...detecting DNA single strand breaks (strand break and incomplete excision repair sites), alkali-labile sites, and ...
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Photodynamic DNA damage induced by phycocyanin and its repair in Saccharomyces cerevisiae
... and repair of DNA lesions induced by the photodynamic action of phy- cocyanin in vitro and in a cellular ...of DNA exposed to PHY plus VL was determined using a set of DNA repair ...
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Saturation diving alters folate status and biomarkers of DNA damage and repair.
... that DNA damage occurred during the dive at some ...a DNA repair ...double-strand DNA break sites ...the DNA damage did not involve double-strand ...enough DNA break accumulation ...
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Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue array.
... all DNA lesions. Prompt and efficient repair of DNA DSBs is critical for maintaining genomic ...DSB repair pathway may cause genetic alterations, chromosome instability, and, ultimately, ...
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Sunlight damage to cellular DNA: Focus on oxidatively generated lesions
... by DNA and non-DNA chromophores present inside the ...of DNA damage by UVB and UVA wavelengths are presented, with emphasis in the photosensitized formation of oxidized DNA ...the DNA ...
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Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo
... enhanced DNA repair, high glutathione levels and functional p53 have a critical role on cisplatin ...in DNA repair ...fewer DNA double-strand breaks and DNA ...
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Alkaline Gel Electrophoresis Assay to Detect DNA Strand Breaks and Repair Mechanisms in Escherichia coli
... measuring DNA strand breaks in eukaryotic ...of DNA linked to the nuclear ...bacterial repair endonucleases that recognize specific kinds of damage in the DNA and convert lesions to DNA ...
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