Efflux Pump
Overexpression of the novel MATE fluoroquinolone efflux pump FepA in Listeria monocytogenes is driven by inactivation of its local repressor FepR.
... the efflux of macrolides, cefotaxime, and heavy metals [22] while the second, encoded by the lde gene, is associated with resistance to hydrophilic FQs as well as with acriflavine and ethidium bromide resistance ...
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EFFECTS OF PSYCHOTROPIC DRUGS AS BACTERIAL EFFLUX PUMP INHIBITORS ON QUORUM SENSING REGULATED BEHAVIORS
... as efflux pumps inhibitors since they also act on human cells and bacterial cells as pump inhibitors (Munoz-Bellido et ...on efflux pump of clinically important pathogens and QS- controlled ...
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Azole resistance in Candida albicans from animals: Highlights on efflux pump activity and gene
... including efflux pump activity, ergosterol content and gene ...A3, efflux pump activity by rhodamine 6G test, ergosterol content and expression of the genes CDR1, CDR2, MDR1, ERG11 by RT- ...
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The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans.
... multidrug efflux pump of the major facilitator superfamily, is a frequent cause of resistance to fluconazole and other toxic compounds in clinical Candida albicans strains, but the mechanism of MDR1 ...
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A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.
... Many botanical compounds possess antimicrobial activity. Thus, it was important to evaluate whether growth effects might confound the measurements of efflux pump inhibition. Towards this goal, the ...
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Biological activity of well defined hydantoin derivatives on efflux pump systems of bacteria and cancer cells
... Over-expressed efflux pumps that extrude a variety of structurally unrelated antibiotics are associated with multidrug resistant (MDR) phenotypes in Gram-negative ...of efflux activity has been essentially ...
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Crystal structure of Escherichia coli CusC, the outer membrane component of a heavy metal efflux pump.
... Copper, while being required for the function of a number of enzymes in Escherichia coli, is also extremely toxic, requiring mechanisms to regulate its levels inside the cell. In E. coli, three systems are known that ...
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Association of efflux pump inihibitors with antileishmanial drugs as an alternative treatment for leishmaniasis
... the efflux of ...use efflux pump inhibitors ...of efflux pumps in a context where macrophages from a cellular line (P388D1) get infected with more resistant Leishmania promastigotes from ...
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Genotypic and phenotypic detection of efflux pump in Rhodococcus equi
... of efflux mechanism by methodologies using EtBr as substrate is widely employed in phenotypic studies to verify efflux pumps (Li and Nikaido, 2004); however, it is based on qualitative results and have also ...
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Efflux pump activity in drug resistance of Staphylococcus aureus
... the efflux pump plasmid-located gene qacA was demonstrated in strain HPV107, a clinical isolate representative of the Iberian MRSA clone (sub-Chapter ...of efflux activity in strain HPV107 due to the ...
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Alternating antibiotics render resistant bacteria beatable.
... treatment with a second drug. Conversely, cross-resistance is when treatment with one drug causes a decreased sensitivity to a second drug. One might expect that ERY and DOX would develop cross-resistance because they ...
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Efflux in fungi: la piece de resistance.
... of efflux pumps in secondary metabolite clusters have been constructed, and most of these mutants retain wild-type levels of mycotoxin secretion ...the efflux pump was expressed in a homologous ...
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Adaptive resistance in bacteria requires epigenetic inheritance, genetic noise, and cost of efflux pumps.
... an efflux pump regulatory network (EPRN) model, we show that the following three mechanisms are essential to obtain adaptive resistance in a bacterial popu- lation: 1) intrinsic variability in the ...
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The Effect of Nitric Oxide Combined with Fluoroquinolones against Salmonella enterica Serovar Typhimurium in Vitro
... In Salmonella, the multiple antibiotic resistance has not been elucidated well. Some resistant mutants have reduced expression of OmpF, while others have had no porin changes. However, the marRAB loci and soxRS genes in ...
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The role of the efflux mechanisms in multidrug resistance in Mycobacterium tuberculosis
... combat efflux mediated resistance involve the modification of antibiotics into derivatives that are minimally affected by efflux and the development of therapeutic agents that inhibit the efflux ...
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Differential gene expression by RamA in ciprofloxacin-resistant Salmonella Typhimurium.
... multidrug efflux pump AcrAB-TolC and decreased expression of porin protein OmpF, thereby conferring multiple drug resistance ...multidrug efflux pump and accessory genes but also genes ...
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Characterization of a pediatric rotary blood pump
... the pump in full operation up to 21 V, with the current saturating at 2 A and the rotational speed around 6000 RPM, as can be seen in Figure ...the pump impeller, as can be seen in Figure ...
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Advanced Fuzzy Logic Heat Pump Controller
... The first is the determination of specific curve of the threshold for stable operation for each heat pump. This would involve intensive and controlled tests to encompass all possible operating ranges. However, it ...
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Int. braz j urol. vol.37 número6
... Although it is well established that cardio- vascular risk factors are associated with ED, once it is present there is mixed information on whether treating the risk factors will treat the ED (13). Re- cently, Mohamed ...
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Multifunctional Heat Pump Installation for Dairy Plants
... [3] SöвlОmОгăM.S.,ăOpОratТonalăМostămТnТmТгatТonăoПă heat pump for milk pasteurization in dairy. Journal of Dairy Research, 2005, v72, p.482-485. [4] SöвlОmОгă M.S.,ă OptТmumă СОată pumpă Тnă mТlkă pasteurizing in ...
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